Protein Alignment bsh and HMX1

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_061815.2
• Gene: HMX1 / 3166
• HGNCID: 5017
• Length: 348
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 91/343 - (26%)
• Similarity: 118/343 - (34%)
• Gaps: 108/343 - (31%)

  Fly    42 TPFSIEHILFQNLNSASNNNNSSDTNGIAANTNNYAPKSSRNAVKSARSAFAHDNNPHKHPSQHS 106
            ||......|.:||.:|........|.|                           :...:...:..
Human    12 TPARASSFLIENLLAAEAKGAGRATQG---------------------------DGSREDEEEDD 49

  Fly   107 HPPQSHPPASASASATATARSNQAASGYAGEDYGKSMHSTPRSNHHSRHGTSHYNGDQISQQLGS 171
            ..|:......|........|...|.:|..||...:::                         ||.
Human    50 DDPEDEDAEQARRRRLQRRRQLLAGTGPGGEARARAL-------------------------LGP 89

  Fly   172 GAAQHPPVPTTQPQPPPPPPLNGGSGASNGVLYPNAPYTDHGFLQMTLGY---LSPSSGTYKSVD 233
            ||....|    :|.|.|.||...|.|.: ...||.|    ||      ||   |||.:....|.:
Human    90 GALGLGP----RPPPGPGPPFALGCGGA-ARWYPRA----HG------GYGGGLSPDTSDRDSPE 139

  Fly   234 -----------------PYFLSQ--ASLFGGAPFFG---------APGCVPELALGLGMGVNALR 270
                             |..:.:  |.|....|..|         .|....|...|:|:|..
Human   140 TGEEMGRAEGAWPRGPGPGAVQREAAELAARGPAAGTEEASELAEVPAAAGETRGGVGVGGG--- 201

  Fly   271 HCRRRKARTVFSDPQLSGLEKRFEGQRYLSTPERVELATALGLSETQVKTWFQNRRMKHKKQLRR 335
              |::|.|||||..|:..||..|:.:||||:.||..||.:|.|:|||||.||||||.|.|:||
Human   202 --RKKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKWKRQL-- 262

  Fly   336 RDNANEPVDFSRSEPGKQ 353
               |.|....|.|.||.|
Human   263 ---AAELEAASLSPPGAQ 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	32/55 (58%)
HMX1	NP_061815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..203		42/245 (17%)
		Homeodomain	206..260	CDD:459649	31/53 (58%)
		HMX family specific domain 1	263..273		3/9 (33%)
		HMX family specific domain 2	276..289		1/2 (50%)