Protein Alignment bsh and EN2

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_001418.2
• Gene: EN2 / 2020
• HGNCID: 3343
• Length: 333
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 77/289 - (26%)
• Similarity: 97/289 - (33%)
• Gaps: 103/289 - (35%)

  Fly   102 PSQHSHPPQ---------SHPPASASASA-TATARSNQAASGYAGEDYGKSMHSTPRSNHHSRHG 156
            |..|.||.:         ..|.......| |..|.:.....|.||.:.|.|          ...|
Human    57 PGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGAS----------GAEG 111

  Fly   157 TSHYNGDQISQQLGSGAAQHPPVPTTQPQPPPPPPLNGGSGASNGVLYPNAPYTDHGFLQMTLGY 221
            .....|.:  |.||||:.          :|...||...|:|   |.| |.|            |.
Human   112 GGGAGGSE--QLLGSGSR----------EPRQNPPCAPGAG---GPL-PAA------------GS 148

  Fly   222 LSPSSGTYKSVDPYFLSQASLFGGAPFFGAPGCVPELAL---GLG--------------MGVN-- 267
            .||..|...|      ...||.|||...|.||...:.:|   |||              .|.|
Human   149 DSPGDGEGGS------KTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANLG 207

  Fly   268 -------ALRHCRR-----------------------RKARTVFSDPQLSGLEKRFEGQRYLSTP 302
                   |..:|.|                       ::.||.|:..||..|:..|:..|||:..
Human   208 AQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQ 272

  Fly   303 ERVELATALGLSETQVKTWFQNRRMKHKK 331
            .|..||..|.|:|:|:|.||||:|.|.||
Human   273 RRQSLAQELSLNESQIKIWFQNKRAKIKK 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	24/55 (44%)
EN2	NP_001418.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..206		39/154 (25%)
		homeobox domain	243..302		26/59 (44%)
		Homeodomain	245..301	CDD:459649	24/55 (44%)
		Engrail_1_C_sig	302..332	CDD:431338	77/289 (27%)