Protein Alignment bsh and EN1

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 81/399 - (20%)
• Similarity: 119/399 - (29%)
• Gaps: 136/399 - (34%)

  Fly    23 PTHSKAAAMASATTMLTTKTPFSIEHILFQNLNSASNNNNSSDTNGIAANTNNYAPKSSRNAVKS 87
            |...:.:|:.:|    ...||..:...|....:.:|.:.:..|:          .|.|.:.|..|
Human     8 PKSQRDSALGAA----AAATPGGLSLSLSPGASGSSGSGSDGDS----------VPVSPQPAPPS 58

  Fly    88 ARSA-----FAHDNNPHKHPSQHSHPPQ-----SHPPASAS------------------------ 118
            ..:|     .||  :||..|.....|||     :|.|..|:
Human    59 PPAAPCLPPLAH--HPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQ 121

  Fly   119 ----ASATATARSNQAASGYAGEDYGK-------------------SMHSTPRSN----HHSRHG 156
                ....|.||......|....|.|:                   |:...|.:|    ..|:..
Human   122 PPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPA 186

  Fly   157 TSHYNGDQISQQLGSGAAQHPPVPTTQPQPPPPPPLNGGSGASNGVLYPNA---PYTDHGFLQMT 218
            .:.....:......:.||....|..........|...||.|:..|...|.|   .|.:||
Human   187 AAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGTKYPEHG----- 246

  Fly   219 LGYLSPSSGTYKSVDPYFLSQASLFGG-------------------APFFGAPGCVPELALGLGM 264
                          :|..|...|..||                   ..:...|...|.
Human   247 --------------NPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPR------- 290

  Fly   265 GVNALRHCRRRK-------ARTVFSDPQLSGLEKRFEGQRYLSTPERVELATALGLSETQVKTWF 322
                .|..:::|       .||.|:..||..|:..|:..||::...|..||..|.|:|:|:|.||
Human   291 ----TRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWF 351

  Fly   323 QNRRMKHKK 331
            ||:|.|.||
Human   352 QNKRAKIKK 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	24/62 (39%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		24/107 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		5/31 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		11/50 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		4/34 (12%)
		Homeodomain	305..360	CDD:459649	23/54 (43%)
		Engrail_1_C_sig	361..391	CDD:431338	81/399 (20%)