Protein Alignment bsh and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Alignment Length: 306
• Identity: 83/306 - (27%)
• Similarity: 105/306 - (34%)
• Gaps: 115/306 - (37%)

  Fly    40 TKTPFSIEHILFQNLNSASNNNNSSDTNGIAANTNNYAPKSSRNAVKSARSAFAHDNNPHKHPSQ 104
            |.||||::.||  ||.....:..|.|.:.....|  .||.|...|      ||        .|..
Mouse     8 TPTPFSVKDIL--NLEQQQRSLASGDLSARLEAT--LAPASCMLA------AF--------KPEA 54

  Fly   105 HSHPPQSHPPASASASATATARSNQAASGYAGEDYGKSMHSTPRSNHHSRHGTSHYNGDQISQQL 169
            :|.|                   ..||||.|                            ::..::
Mouse    55 YSGP-------------------EAAASGLA----------------------------ELRAEM 72

  Fly   170 GSGAAQHPPVPTTQPQPPPPPPLNGGSGASNGVLYPNAPYTDHGFLQMTLGYLSPSSGTYKSVDP 234
            |               |.|.||....:..:....||.|             |..|........|.
Mouse    73 G---------------PAPSPPKCSPAFPAAPTFYPGA-------------YGDPDPAKDPRADK 109

  Fly   235 YFLSQASLFGGAPFFGAPGCVPELALGLGM----GVNALRHCRRRKARTVFSDPQLSGLEKRFEG 295
            ..|                |..:.|:.|..    |....|..||||.|.:||..|:..||:||:.
Mouse   110 KEL----------------CALQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQ 158

  Fly   296 QRYLSTPERVELATALGLSETQVKTWFQNRRMKHKKQLRRRDNANE 341
            |||||.|||.:||:.|.|:.||||.||||||.|.|:|  |:|...|
Mouse   159 QRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQ--RQDQTLE 202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	33/55 (60%)
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	30/49 (61%)