DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bsh and DLX3

DIOPT Version :9

Sequence 1:	NP_477350.2	Gene:	bsh / 35266	FlyBaseID:	FBgn0000529	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_005211.1	Gene:	DLX3 / 1747	HGNCID:	2916	Length:	287	Species:	Homo sapiens

Alignment Length:	261	Identity:	70/261 - (26%)
Similarity:	102/261 - (39%)	Gaps:	84/261 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 YAGEDYGKSMHSTPRSNHHSRHGTSHYNGDQISQQLGSGAAQHPPVPTTQPQPPPPPPLNGGSGA 198
            |:|:.||::::  |.:.||      .:|                              |||.:|
Human    51 YSGQPYGQTVN--PYTYHH------QFN------------------------------LNGLAG- 76

  Fly   199 SNGVLYPNAPYTDHGFLQMTLGYLSPSSGTYK-----SVDPYFLSQASLFGGAPFFGAPGCVPEL 258
             .|...|.:.|        |.|......|.|:     :.||..:.:.               ||.
Human    77 -TGAYSPKSEY--------TYGASYRQYGAYREQPLPAQDPVSVKEE---------------PEA 117

  Fly   259 ALGLGMGVNALRHCRRRKARTVFSDPQLSGLEKRFEGQRYLSTPERVELATALGLSETQVKTWFQ 323
            .:.:..|    :..:.||.||::|..||:.|::||:..:||:.|||.|||..|||::||||.|||
Human   118 EVRMVNG----KPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQ 178

  Fly   324 NRRMKHKKQLRRRDNANEPVDFSRSEPGKQPGEATSSS------GDSKHGKLNPGSVGGTPTQPT 382
            |||.|.||..:   |...|::.|   |......|.:|.      ..|.|....|......|..|.
Human   179 NRRSKFKKLYK---NGEVPLEHS---PNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPY 237

  Fly   383 S 383
            |
Human   238 S 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeobox	278..330	CDD:278475	30/51 (59%)
DLX3	NP_005211.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		DLL_N	27..107	CDD:403572	19/103 (18%)
		COG5576	<109..232	CDD:227863	46/147 (31%)
		homeobox	129..188		34/58 (59%)
		Homeobox	132..186	CDD:395001	30/53 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..287		10/47 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D574097at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920