DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bsh and DLX2

DIOPT Version :9

Sequence 1:	NP_477350.2	Gene:	bsh / 35266	FlyBaseID:	FBgn0000529	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_004396.1	Gene:	DLX2 / 1746	HGNCID:	2915	Length:	328	Species:	Homo sapiens

Alignment Length:	292	Identity:	80/292 - (27%)
Similarity:	111/292 - (38%)	Gaps:	80/292 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 MHST---PRSNHHSRHGTSHYNGDQISQQLGSGAAQHPPVPTTQPQPPPPPPLN----------- 193
            ||||   ..|.:|.........|........|.::.|      :||..|..|::
Human    12 MHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLH------KPQESPTLPVSTATDSSYYTNQ 70

  Fly   194 ---GGSGASNGVLYP-------------NAPYTDHGFLQMTLGYLSPSSGTYKSVDPYFLSQASL 242
               .|.|...|..|.             |.||:...  ...|||    :..|.|..||..|
Human    71 QHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKS--SYDLGY----TAAYTSYAPYGTS---- 125

  Fly   243 FGGAPFFGAP---GCVPELALGLGMGVNALRHCRRRKARTVFSDPQLSGLEKRFEGQRYLSTPER 304
              .:|....|   ...||:.:     ||. :..:.||.||::|..||:.|::||:..:||:.|||
Human   126 --SSPANNEPEKEDLEPEIRI-----VNG-KPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPER 182

  Fly   305 VELATALGLSETQVKTWFQNRRMKHKKQLRRRDNANE------------------PVDFSRSEPG 351
            .|||.:|||::||||.||||||.|.||..:..:..:|                  |..:....|.
Human   183 AELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPASWDFGVPQ 247

  Fly   352 KQPGEATSSSGDSKHGKLNPGSVGGTPTQPTS 383
            :..|.....||.|     ..||.|.:|:...|
Human   248 RMAGGGGPGSGGS-----GAGSSGSSPSSAAS 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeobox	278..330	CDD:278475	30/51 (59%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..81		11/70 (16%)
		DLL_N	51..132	CDD:289198	19/92 (21%)
		Homeobox	155..208	CDD:278475	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..270		10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D574097at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920