Protein Alignment bsh and CDX1

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 80/285 - (28%)
• Similarity: 104/285 - (36%)
• Gaps: 91/285 - (31%)

  Fly   160 YNGDQISQQLGSG-AAQHPPVPTTQP------------QPPPPPPLNGGSGASNGVLYPNAPYTD 211
            |.|......||.| .|..||.|...|            :|.|.||      .:.|..:| ||..|
Human    14 YPGPARPASLGLGPQAYGPPAPPPAPPQYPDFSSYSHVEPAPAPP------TAWGAPFP-APKDD 71

  Fly   212 ----HGFLQMTLGYLSPSSGTYKSVDPYFLSQASL-FGGAPFF------------------GAPG 253
                :|     .|..:|::           |.||| ||..|.|                  |.||
Human    72 WAAAYG-----PGPAAPAA-----------SPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPG 120

  Fly   254 C---------VP------ELALGLGMGVNALRHCRRRKARTVFSDPQLSGLEKRFEGQRYLSTPE 303
            .         .|      .:|.|.|.|....|  .:.|.|.|::|.|...|||.|...||::...
Human   121 TPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTR--TKDKYRVVYTDHQRLELEKEFHYSRYITIRR 183

  Fly   304 RVELATALGLSETQVKTWFQNRRMKHKKQLRRRDNANEPVDFSRSEPGKQPGEA---TSSSGDSK 365
            :.|||..|||:|.|||.||||||.|.:|..:::....:|         .||..|   |::.....
Human   184 KSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQP---------PQPPMAHDITATPAGPS 239

  Fly   366 HGKLNPGSVGGTPT---QPTSEQQL 387
            .|.|.|.:.....|   .|..|:.|
Human   240 LGGLCPSNTSLLATSSPMPVKEEFL 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	28/55 (51%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		39/163 (24%)
		Caudal_act	13..142	CDD:461413	34/150 (23%)
		Homeodomain	156..211	CDD:459649	28/54 (52%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		8/20 (40%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		14/67 (21%)