DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fbp and FBP2

DIOPT Version :9

Sequence 1:	NP_724223.4	Gene:	fbp / 35265	FlyBaseID:	FBgn0032820	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_003828.2	Gene:	FBP2 / 8789	HGNCID:	3607	Length:	339	Species:	Homo sapiens

Alignment Length:	332	Identity:	203/332 - (61%)
Similarity:	261/332 - (78%)	Gaps:	3/332 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MTQQRPAFDSNAMTLTRFVLQEQRKFKSATGDLSQLLNSIQTAIKATSSAVRKAGIAKLHGFAGD 74
            ||.:.| |:::.:||||:|:::.|:.| .||:|:|||||:.|||||.||||||||:|.|:|.||.
Human     1 MTDRSP-FETDMLTLTRYVMEKGRQAK-GTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGIAGS 63

  Fly    75 VNVQGEEVKKLDVLSNELFINMLKSSYTTCLMVSEENENVIEVEVEKQGKYIVCFDPLDGSSNID 139
            |||.|:||||||||||.|.|||::|||:||::|||||::.|....||:|||:|||||||||||||
Human    64 VNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNID 128

  Fly   140 CLVSIGSIFAIYRKKSDGPPTVEDALQPGNQLVAAGYALYGSATAIVLGLGSGVNGFTYDPAIGE 204
            ||.|||:|||||||.|:..|:.:||||.|..:||||||||||||.:.|..|.||:.|..|||:||
Human   129 CLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGE 193

  Fly   205 FVLTDPNMRVPEKGKIYSINEGYAADWEDGVFNYIAAKKDPAKGK-PYGARYVGSMVADVHRTIK 268
            |||.:.::::.:||||||:|||||..::.....|:..||.|..|. |||||||||||||||||:.
Human   194 FVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLV 258

  Fly   269 YGGIFIYPATKSAPSGKLRLLYECVPMAYLMIQAGGLASDGKISILDIVPKKIHERSPIFLGSKS 333
            |||||:|||.:.:|.|||||||||.|:||::.||||||:.|...:||:.|:.||:|.|:.|||..
Human   259 YGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPE 323

  Fly   334 DVEEALS 340
            ||:|.|:
Human   324 DVQEYLT 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fbp	NP_724223.4	FBPase	28..342	CDD:238214	195/314 (62%)
FBP2	NP_003828.2	Important for interaction with ALDOA. /evidence=ECO:0000269\|PubMed:18214967	3..10		2/7 (29%)
		FBPase	18..329	CDD:238214	194/311 (62%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:19626708	204..208		1/3 (33%)
		Substrate binding	213..216		2/2 (100%)
		Substrate binding	245..249		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149269
Domainoid	1	1.000	257	1.000	Domainoid score	I2024
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55784
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1753
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61707
OrthoDB	1	1.010	-	-		D1381522at2759
OrthoFinder	1	1.000	-	-		FOG0001569
OrthoInspector	1	1.000	-	-		otm41587
orthoMCL	1	0.900	-	-		OOG6_101108
Panther	1	1.100	-	-	O	PTHR11556
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R425
SonicParanoid	1	1.000	-	-		X880
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940