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Protein Alignment Dus3 and DUS3L

DIOPT Version :10

Sequence 1:	NP_610000.1	Gene:	Dus3 / 35264	FlyBaseID:	FBgn0032819	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_064560.2	Gene:	DUS3L / 56931	HGNCID:	26920	Length:	650	Species:	Homo sapiens

Alignment Length:	640	Identity:	301/640 - (47%)
Similarity:	389/640 - (60%)	Gaps:	49/640 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSGICYIKPEYLVT--------EADG----------GSAAANTENSDTNKRKR-EDG----GE- 41
            ::.|:..||.:||.|        ||.|          |..|.|.......||.| |||    |:
Human    23 LERGVAPIKRQYLTTKEQFHQFLEAKGQEKTCRETEVGDPAGNELAEPEAKRIRLEDGQTADGQT 87

  Fly    42 ---VEAGEKKKWDKKERKRGQNKNRPVFKDERY--SHLCHSLIDGTGGEPCSLAN-CRYVHDLDA 100
               .|.||:.:..|  |.|||||.||..|...|  :.||.|||..:..: |...: ||::||:..
Human    88 EEAAEPGEQLQTQK--RARGQNKGRPHVKPTNYDKNRLCPSLIQESAAK-CFFGDRCRFLHDVGR 149

  Fly   101 YLAAKGEDLGPECYVYTTKGYCARGVSCRFAKAHTDEQGRNLKREDYDENA--PPTTCNGVSSEL 163
            ||..|..||||.|.::.|.|.|..||:||||.||...:|:||.:|:.....  ||:..||:...|
Human   150 YLETKPADLGPRCVLFETFGRCPYGVTCRFAGAHLRPEGQNLVQEELAARGTQPPSIRNGLDKAL 214

  Fly   164 QVRLRKHEYDFSRSKE-LIKMAEKLRDARKLKEQQEKEKNPSEET-GEKQPSETTEILDAEKQTD 226
            |.:|||.|..|.|::: |.:.::....|..:.|....|..|.:|. |.:|       :.|...|.
Human   215 QQQLRKREVRFERAEQALRRFSQGPTPAAAVPEGTAAEGAPRQENCGAQQ-------VPAGPGTS 272

  Fly   227 T-KSKPTAT-GCAIDDSAIGRDADHKPAVDFREKLVLSPLTTLGNLPFRRICKEFGADITCGEMA 289
            | .|.|..| |...|:..:......|..:|.|.||.|:||||.||||||||||.||||:||||||
Human   273 TPPSSPVRTCGPLTDEDVVRLRPCEKKRLDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMA 337

  Fly   290 CAQPLLKGMGQEWALTKRHQSEDVFGVQLCGNNPNMLNQAAQVIHETAQVDFIDLNIGCPIDLIY 354
            ....||:|...||||.||||.||:|||||.|..|:.:.:.|:::..|.:|||:|:|:||||||:|
Human   338 VCTNLLQGQMSEWALLKRHQCEDIFGVQLEGAFPDTMTKCAELLSRTVEVDFVDINVGCPIDLVY 402

  Fly   355 QQGGGSALMRRTNILELTVRSCAALSDRLPFTVKMRTGIYADKSVAHELLPLVEEWGASAVTLHG 419
            ::|||.|||.|:...:..||....:.| :|.|||:|||:....::||.|||.:.:||.:.|||||
Human   403 KKGGGCALMNRSTKFQQIVRGMNQVLD-VPLTVKIRTGVQERVNLAHRLLPELRDWGVALVTLHG 466

  Fly   420 RSREQRYTKHANWAYIEECAAKAKCMPVIGNGDILSYEDYMERRTLAPHVCSVMIGRGALIKPWI 484
            |||||||||.|:|.|||||...|..||:.|||||||:||  ..|.:...|..:||.||||:|||:
Human   467 RSREQRYTKLADWQYIEECVQAASPMPLFGNGDILSFED--ANRAMQTGVTGIMIARGALLKPWL 529

  Fly   485 FQEIKEKQAWSPSSGQRYEMLQKFCNYGLEHWGSDTKGVETTRRFLLEWQSFLYRYIPEALQTAP 549
            |.||||::.|..||.:|.::|:.|.|||||||||||:|||.||||||||.|||.||:|..|....
Human   530 FTEIKEQRHWDISSSERLDILRDFTNYGLEHWGSDTQGVEKTRRFLLEWLSFLCRYVPVGLLERL 594

  Fly   550 PQKINARPQKYRGRDEMETLMSSGNAADWVKLSESLLGRVPEGFTFVPKHKANAF 604
            ||:||.||..|.|||.:||||:|..||||:::||.|||.||..|.|:|||||||:
Human   595 PQRINERPPYYLGRDYLETLMASQKAADWIRISEMLLGPVPPSFAFLPKHKANAY 649

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.