DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10463 and dus3l

DIOPT Version :9

Sequence 1:	NP_610000.1	Gene:	CG10463 / 35264	FlyBaseID:	FBgn0032819	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_012819922.1	Gene:	dus3l / 394959	XenbaseID:	XB-GENE-943237	Length:	645	Species:	Xenopus tropicalis

Alignment Length:	640	Identity:	285/640 - (44%)
Similarity:	389/640 - (60%)	Gaps:	58/640 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSGICYIKPEYLVT--------EADG-------------GSAAANTENSD-----TNKRKREDG 39
            :|.|:..|||:||.|        :|||             |:.|.||..::     ..||.:.|.
Frog    27 LDRGVAAIKPQYLTTKEKFHVFIDADGKEVVDKQTCSELSGNDAENTVRAEDAAEPEAKRIKLDD 91

  Fly    40 GEVEAGEK-----KKWDKKERKRGQNKNRPVFKDERY--SHLCHSLIDGTGGEPCSLAN-CRYVH 96
            |..|..:|     :...:|:|.|||||:||..|..::  :.||.|:......: |...: |:::|
Frog    92 GTGEGQDKPPTSAENKQEKKRARGQNKSRPHMKHSQFEENKLCPSVTQECASK-CFFGDKCKFLH 155

  Fly    97 DLDAYLAAKGEDLGPECYVYTTKGYCARGVSCRFAKAHTDEQGRNLKREDYDE--NAPPTTCNGV 159
            |:..|::.|.||:.|.||:|.|.|.|..||:|||||:|..:..:||..|:..:  .......|.:
Frog   156 DVAKYVSEKPEDIRPNCYLYETFGKCIYGVTCRFAKSHLGDNFKNLINEELMKQWEGQVLVKNSL 220

  Fly   160 SSELQVRLRKHEYDFSRSKELIKMAEKLRDARKLKEQQEKEKNPSEETGEKQPSETTEILDAEKQ 224
            ...|:.:|||.:..|.::.:.:|:..|..|:.|:|....||.|.::...:..|
Frog   221 DKSLKEQLRKRKVVFEKTDKYLKLCNKSGDSLKIKSPVVKEDNAAQVVQKDSP------------ 273

  Fly   225 TDTKSKPTATGCAIDDSAIGRDADHKPAVDFREKLVLSPLTTLGNLPFRRICKEFGADITCGEMA 289
                  .|..|...|:..:......|..:|||.||.|:||||.|||||||:||.|||||||||||
Frog   274 ------VTTVGAVTDEDLVKLRPCEKKTIDFRNKLYLAPLTTCGNLPFRRLCKRFGADITCGEMA 332

  Fly   290 CAQPLLKGMGQEWALTKRHQSEDVFGVQLCGNNPNMLNQAAQVIHETAQVDFIDLNIGCPIDLIY 354
            ....||:|...||||.|||.|||:|||||.|..|:.:.:.|::::.|..|||:|:|:||||||:|
Frog   333 MCTNLLQGQPSEWALLKRHHSEDIFGVQLEGAFPDTMTKCAELLNRTIDVDFVDINVGCPIDLVY 397

  Fly   355 QQGGGSALMRRTNILELTVRSCAALSDRLPFTVKMRTGIYADKSVAHELLPLVEEWGASAVTLHG 419
            ::|||..||.|||..|..|:...::.| :|.|||:|||:....::||:|:|.:.:||.|.|||||
Frog   398 KKGGGCGLMNRTNKFEQIVKGMNSVLD-VPLTVKIRTGVQEKINIAHKLIPNLRDWGVSLVTLHG 461

  Fly   420 RSREQRYTKHANWAYIEECAAKAKCMPVIGNGDILSYEDYMERRTLAPHVCSVMIGRGALIKPWI 484
            |||||||||.|:|.||.:||..|..:|:.|||||:||||  ..|.|...|..:|:.||||:|||:
Frog   462 RSREQRYTKLADWEYIAQCADIASPLPLFGNGDIISYED--ANRALQTGVSGIMLARGALLKPWL 524

  Fly   485 FQEIKEKQAWSPSSGQRYEMLQKFCNYGLEHWGSDTKGVETTRRFLLEWQSFLYRYIPEALQTAP 549
            |.||||::.|..||.:|:::|:.|.||||||||||.:|||.||||:|||.|||.||||..|....
Frog   525 FTEIKEQRHWDISSTERFDILKDFTNYGLEHWGSDCQGVEKTRRFMLEWLSFLCRYIPIGLLEHV 589

  Fly   550 PQKINARPQKYRGRDEMETLMSSGNAADWVKLSESLLGRVPEGFTFVPKHKANAF 604
            |||||.||..|.|||.|||||:|.|..||:|:||.|||.||..|:|:||||||::
Frog   590 PQKINERPPYYMGRDYMETLMASQNVTDWIKISEMLLGPVPPNFSFLPKHKANSY 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10463	NP_610000.1	DusA	253..547	CDD:223120	170/293 (58%)
CG10463	NP_610000.1	DUS_like_FMN	258..492	CDD:239200	133/233 (57%)
dus3l	XP_012819922.1	DusA	296..571	CDD:223120	159/277 (57%)
dus3l	XP_012819922.1	DUS_like_FMN	301..533	CDD:239200	133/234 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1655
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6533
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1187
OMA	1	1.010	-	-		QHG55928
OrthoDB	1	1.010	-	-		D1016307at2759
OrthoFinder	1	1.000	-	-		FOG0003900
OrthoInspector	1	1.000	-	-		otm48319
Panther	1	1.100	-	-	LDO	PTHR45846
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R356
SonicParanoid	1	1.000	-	-		X2206
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110