DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10631 and znf574

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	NP_001164307.1	Gene:	znf574 / 798589	ZFINID:	ZDB-GENE-100922-259	Length:	1009	Species:	Danio rerio

Alignment Length:	433	Identity:	90/433 - (20%)
Similarity:	147/433 - (33%)	Gaps:	118/433 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 GNESLPICQRCKEVFFKKQVYLRHVAESNCGIQEYDFK----------------CSTCPMSFMTT 329
            |...:..|..|.:.||:.....||:.....|:||...:                |..||.||...
Zfish   582 GGSRIYSCPICDKRFFQPTSLKRHMMTHQEGVQERRTRGRGKGRGPSSDGRLHICPECPASFKLE 646

  Fly   330 EELQRHKLHHRADRFFC-------------------HK--------YCGKHF------DT-IAEC 360
            .:|:.|:|.|.:..|.|                   |:        .||..|      || :..|
Zfish   647 AQLKSHRLLHTSHPFPCSVCGEAFIRRKELDLHSLIHQDKEPKMCPNCGSQFLNQTVLDTHLQRC 711

  Fly   361 EAHEYMQHEY---------DSFVCNMCSGTFATREQLYAHLPQHKFQQRFDCPI--CRLWYQTAL 414
            ...:..|.:|         ....|:||.....|::.|..|...|..|....||:  ||..:.::.
Zfish   712 TGEQTGQRKYKGQGRGKVGGQLECDMCGHRCVTQDGLDLHRLSHTGQTPLRCPLAPCRRRFASSA 776

  Fly   415 ELHEHRLA----------AP-----YFCGKYYTGGQSSSASQSQAQQHQTNYKLQDCHMATMEMP 464
            .|.||.:|          ||     .||||.:... |:.....:...::..::...|.....::|
Zfish   777 ALGEHLVAHCCGALGKRNAPRRFTCEFCGKEFAYA-STFTVHMRTHTNERPFECAQCGKRFRQLP 840

  Fly   465 TTPHHKTTPSGSSLPATAALNSLLQQRQANADGAAMFAASAMKNEVNVKM-ERSYSNSTSESSYS 528
            ....|:...||.. |.|..:           .|.:...|:.:.....|.. ||.|......:::.
Zfish   841 HLQDHERIHSGER-PFTCWV-----------CGKSFSVAARLTEHARVHSGERPYVCPRCPTAFR 893

  Fly   529 VQDSGYNNAYGSDSSM--HAGAIAGPQAHSSTLDDSEDALCCVPLCGVRKSTSPTLQFFTFP--K 589
            .:.:       .|..|  ||.....|.|.:...||:  |:..:.|.....|:||:......|  :
Zfish   894 SRPN-------LDKHMRIHANDPVDPTAQNVMDDDA--AVQTILLVQESASSSPSSSSSVMPVVQ 949

  Fly   590 DEKYLNQ-------WLH-NLKM--FHIPAASYANFRICSMHFP 622
            :..::.:       :|| |:.|  ..:||.|     :.||:.|
Zfish   950 EGMFVTEEGGSSVVFLHPNMSMPTITVPAIS-----VPSMNMP 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	6/22 (27%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		DM3	584..642	CDD:128933	11/51 (22%)
		DM3	683..738	CDD:128933
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
znf574	NP_001164307.1	PRK10905	<56..>233	CDD:236792
		C2H2 Zn finger	235..255	CDD:275370
		C2H2 Zn finger	265..285	CDD:275370
		CpXC	429..>480	CDD:291051
		C2H2 Zn finger	429..450	CDD:275368
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	533..553	CDD:275368
		COG5048	557..905	CDD:227381	68/342 (20%)
		C2H2 Zn finger	561..581	CDD:275368
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		C2H2 Zn finger	663..683	CDD:275368	1/19 (5%)
		C2H2 Zn finger	691..708	CDD:275368	5/16 (31%)
		C2H2 Zn finger	735..755	CDD:275370	6/19 (32%)
		C2H2 Zn finger	763..785	CDD:275368	7/21 (33%)
		zf-C2H2	799..821	CDD:278523	5/22 (23%)
		C2H2 Zn finger	801..821	CDD:275368	5/20 (25%)
		zf-H2C2_2	816..838	CDD:290200	1/21 (5%)
		C2H2 Zn finger	829..849	CDD:275368	3/19 (16%)
		zf-H2C2_2	841..865	CDD:290200	6/35 (17%)
		C2H2 Zn finger	857..877	CDD:275368	2/30 (7%)
		C2H2 Zn finger	885..905	CDD:275368	2/26 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930