Protein Alignment CG10631 and THAP9

DIOPT Version :10

• Sequence 1: NP_609998.1
• Gene: CG10631 / 35262
• FlyBaseID: FBgn0032817
• Length: 3781
• Species: Drosophila melanogaster
• Sequence 2: XP_047272121.1
• Gene: THAP9 / 79725
• HGNCID: 23192
• Length: 916
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 151/740 - (20%)
• Similarity: 244/740 - (32%)
• Gaps: 255/740 - (34%)

  Fly  1778 YRYPRSEDLLEKW-RANLRLAPDQCRGR----------ICADHF-ESQVRG---KLKLKTGAVPT 1827
            ||:|.......|| ||..|:.|   |.:          :|:.|| ||....   :.|||.||||:
Human    39 YRFPTDTIQRSKWIRAVNRVDP---RSKKIWIPGPGAILCSKHFQESDFESYGIRRKLKKGAVPS 100

  Fly  1828 LNL------GHDEGL---------IYDNEAIKVGMTEEEEGSSEMTRLKPKRELIDEEEEELEAE 1877
            ::|      .|.:|.         :.||..   .:..|:...|..|.|....|.:.|.::.|:..
Human   101 VSLYKIPQGVHLKGKARQKILKQPLPDNSQ---EVATEDHNYSLKTPLTIGAEKLAEVQQMLQVS 162

  Fly  1878 EE----PHEHDMYDEDEKDGHYFDPLELVETFAEH---PSDDEAEYRGDEEDERDEDEDLDEAEH 1935
            ::    ...:.|.  .::.|     |.|::...|.   ..:.|...|....|.:.|..:..|.:.
Human   163 KKRLISVKNYRMI--KKRKG-----LRLIDALVEEKLLSEETECLLRAQFSDFKWELYNWRETDE 220

  Fly  1936 FHPDNPPTPPTIPLRREKPANNVTPICCLRHCRKERT---------AFHLLSTFGFPKDR----- 1986
            :..:......|:.|...|..:.|..|..|.|....||         .|: .:.|.|.:.|
Human   221 YSAEMKQFACTLYLCSSKVYDYVRKILKLPHSSILRTWLSKCQPSPGFN-SNIFSFLQRRVENGD 284

  Fly  1987 ------QLLLK---------WCANLH------------LNPDD-----------CIG-----RVC 2008
                  .||:|         |..:.|            |:.|:           .:|     |..
Human   285 QLYQYCSLLIKSMPLKQQLQWDPSSHSLQGFMDFGLGKLDADETPLASETVLLMAVGIFGHWRTP 349

  Fly  2009 IEHF---------QPEVLGTR--KLKQNAVPTLNVGHD---------EPLRYSCNGMDLDQEQLQ 2053
            :.:|         |.::|...  ||....:..|.|..|         :.|....:|.|:......
Human   350 LGYFFVNRASGYLQAQLLRLTIGKLSDIGITVLAVTSDATAHSVQMAKALGIHIDGDDMKCTFQH 414

  Fly  2054 PQHSVFRL-WSLKHCRKRKLTEPPDIR---QNKWSAE----VRKMQRLRMEMKMKIGREIKLEVQ 2110
            |..|..:: :....|...:|     ||   ||..|.:    :...|.|           ::|...
Human   415 PSSSSQQIAYFFDSCHLLRL-----IRNAFQNFQSIQFINGIAHWQHL-----------VELVAL 463

  Fly  2111 TEREMKSKEKTPTTSLGKIKLEICCINSCANDDVNQLLQLPEDQNLLRKWQHNLKLSVDTDFKEI 2175
            .|:|:.:.|:.|:| |..:|..:..:||     ..||.    .:::....::.|.|    |....
Human   464 EEQELSNMERIPST-LANLKNHVLKVNS-----ATQLF----SESVASALEYLLSL----DLPPF 514

  Fly  2176 QVCLK--HFEEQVVQNGKPLEQAVPTLQLDQNSWNIYRNSGNC--------LFPECSNSSSDQL- 2229
            |.|:.  ||                 |:|..|.::|: ||.||        |.||..:..:..|
Human   515 QNCIGTIHF-----------------LRLINNLFDIF-NSRNCYGKGLKGPLLPETYSKINHVLI 561

  Fly  2230 -------SFVDLPGNAVIRDAW-MSHLNLPPSSEGLLCSEHFMQLFEQVEYPKVLAAQDLEDLQW 2286
                   :..|...|.:|:... :..|..      ||.:|....|::...:|||:
Human   562 EAKTIFVTLSDTSNNQIIKGKQKLGFLGF------LLNAESLKWLYQNYVFPKVM---------- 610

  Fly  2287 IVDELRCAVPSCSSKSDGDLQLIPFPKKDATLLKWLQNTKISYDHLK--HKSYR-ICVLHFEPTC 2348
                                   |||        :|...|.|:|||:  .|..| :.|....|||
Human   611 -----------------------PFP--------YLLTYKFSHDHLELFLKMLRQVLVTSSSPTC 644

  Fly  2349 LEANFPKAWAIPTLHLNHDDELHLN 2373
            :.  |.||:..........||:.|:
Human   645 MA--FQKAYYNLETRYKFQDEVFLS 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368
		C2H2 Zn finger	319..339	CDD:275368
		DM3	584..642	CDD:128933
		DM3	683..738	CDD:128933
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933	23/73 (32%)
		DM3	1980..2033	CDD:128933	18/111 (16%)
		DM3	2147..2202	CDD:128933	9/56 (16%)
		DM3	2308..2365	CDD:128933	18/59 (31%)
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3622..>3673	CDD:461662
		DM3	3690..3748	CDD:128933
THAP9	XP_047272121.1	THAP	<39..101	CDD:461662	22/64 (34%)
		Tnp_P_element	<229..401	CDD:288840	31/172 (18%)