DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10631 and ZNF667

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	NP_001308285.1	Gene:	ZNF667 / 63934	HGNCID:	28854	Length:	610	Species:	Homo sapiens

Alignment Length:	488	Identity:	94/488 - (19%)
Similarity:	149/488 - (30%)	Gaps:	158/488 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 NIMTGSYPYIKSEPMEAYQQPPNPMAPPPAPEVLIKSEPIDEHSYKSNY---------------- 230
            ||.||..|:..|...:|::|         ...:|:...   .||.|.::
Human   164 NIHTGEKPFECSNCRKAFRQ---------ISSILLHQR---IHSGKKSHECNKCGESFNQRTTLI 216

  Fly   231 ----IDDNTPFADFSK-----------------------------FSEFSEDMLSPKVELTVKDE 262
                |.|.....|..|                             |::.|..:|..|:....|..
Human   217 LHMRIHDGKEILDCGKALSQCQSFNIHQKIHVVGNVCQCRKCGKAFNQMSSLLLHKKIHNGKKTH 281

  Fly   263 SYGRTTSSFLRRK-------------------------QQSDRGNESLPICQRCKEVFFKKQVYL 302
            .|.:....|.::.                         ||.....|:...|::|.::|.:....:
Human   282 KYNKCGRGFKKKSVFVVHKRIHAGEKIPENAKALSQSLQQRSHHLENPFKCRKCGKLFNRISPLM 346

  Fly   303 RHVAESNCGIQEYDFKCSTCPMSFMTTEEL-----------------------------QRHKLH 338
            .|   ......|..:||..|...|.....|                             |..|:|
Human   347 LH---QRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCEKVCNRHSSLIQHQKVH 408

  Fly   339 HRADRFFCHKYCGKHFDTIAECEAHEYMQHEYDSFVCNMCSGTFATREQLYAHLPQHKFQQRFDC 403
            .:..:.|..|.|||.|...|..:.|:.:..|...|.||.||..|..:..|..|...|..::.:.|
Human   409 TKKKKLFECKECGKMFSGTANLKIHQNIHSEEKPFKCNKCSKVFGRQSFLIEHQRIHTGEKPYQC 473

  Fly   404 PICRLWYQTALELHEHRLA----APY---FCGKYYTGGQSSSASQSQAQQHQTN---YKLQDCHM 458
            ..|...:...:.|..|:..    .||   .|||.:    |.||..:|.::..|.   |..:.|..
Human   474 EECGKAFSHRISLTRHKRIHTEDRPYECDQCGKAF----SQSAHLAQHERIHTGEKPYTCKTCGK 534

  Fly   459 ATMEMPTTPHHKTTPSGSSLPATAALNSLLQQRQANADGAAMFAASAMKNEVNVKMERSYSNSTS 523
            |..:..:...|:.:.:|.            :..:.|..|.|..:.|.:     ::.:||:|   |
Human   535 AFSQRTSLILHERSHTGE------------KPYECNECGKAFSSGSDL-----IRHQRSHS---S 579

  Fly   524 ESSYSVQDSGYNNAYGSDSSMHAGAIAGPQAHS 556
            |..|.....|  .||...||:    |.....||
Human   580 EKPYECSKCG--KAYSRSSSL----IRHQNTHS 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	4/22 (18%)
		C2H2 Zn finger	319..339	CDD:275368	6/48 (13%)
		DM3	584..642	CDD:128933
		DM3	683..738	CDD:128933
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
ZNF667	NP_001308285.1	KRAB	15..74	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..139
		COG5048	141..601	CDD:227381	92/481 (19%)
		C2H2 Zn finger	146..166	CDD:275368	1/1 (100%)
		C2H2 Zn finger	174..194	CDD:275368	4/31 (13%)
		C2H2 Zn finger	202..222	CDD:275368	0/19 (0%)
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	284..303	CDD:275368	1/18 (6%)
		C2H2 Zn finger	332..352	CDD:275368	4/22 (18%)
		C2H2 Zn finger	360..380	CDD:275368	4/19 (21%)
		C2H2 Zn finger	388..408	CDD:275368	2/19 (11%)
		C2H2 Zn finger	417..437	CDD:275368	7/19 (37%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	473..493	CDD:275368	4/19 (21%)
		C2H2 Zn finger	501..521	CDD:275368	7/23 (30%)
		C2H2 Zn finger	529..549	CDD:275368	3/19 (16%)
		C2H2 Zn finger	557..577	CDD:275368	5/24 (21%)
		C2H2 Zn finger	585..605	CDD:275368	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930