DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10631 and znf740a

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	XP_005172837.1	Gene:	znf740a / 571608	ZFINID:	ZDB-GENE-030131-5064	Length:	543	Species:	Danio rerio

Alignment Length:	715	Identity:	137/715 - (19%)
Similarity:	203/715 - (28%)	Gaps:	276/715 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 QHISQQRPYMGHNIMTGSYPYIKSEPMEAYQQPPNPMAPPPAPEVLIKSEPIDEHSYKSNYIDDN 234
            |...|:|...||.::                  |..|..||   :|::.|
Zfish    56 QRDMQERGTQGHMVL------------------PTSMTCPP---LLLRKE--------------- 84

  Fly   235 TPFADFSKFSEFSEDMLSPKVELTVKDESYGRTTSSFLRRKQ-------QSDRGNESLP------ 286
               |||:......|..:.|..::.:|.::....|.|.:|.:.       ..:.||..|.
Zfish    85 ---ADFTAPRLLDEKEMRPSEDMQLKKKTRKSGTPSKVREQDGPAGKAVVDENGNCPLSKVQKNF 146

  Fly   287 ICQRCKEVFFKKQVYLRHVAESNCGIQEYDFKCSTCPMSFMTTEELQRHKLHHRADRFFCHKYCG 351
            ||..|...|.......||:. .:.|  |..|.|:.|.|.|:....|:||.|.|...:.:....|.
Zfish   147 ICDHCYGAFRSGYHLKRHIL-IHTG--EKPFACAVCDMRFIQRYHLERHSLTHTGVKPYACSMCD 208

  Fly   352 KHFDTIAECEAHEYMQHEYDSFVCNMCSGTFATREQLYAHLPQHKFQQRFDCPIC--RLWYQTAL 414
            ..|......|.|.........:.|.||...|..|..|..|...|...:.:.|.:|  |.:.:..|
Zfish   209 MRFFQRYHLERHSLTHTGVKPYACTMCDMRFFQRYHLQRHSLIHTGVKPYACSMCDRRFFQRYHL 273

  Fly   415 ELHE--HRLAAPYFCG----KYYTGGQSSSASQSQAQQH---QTNYKLQDCHMATMEMPTTPHHK 470
            :.|.  |....||.|.    :::        .:...|:|   .|..|...|.|..|......|
Zfish   274 QRHSLTHTGVKPYACSICDMRFF--------QRYHLQRHSLTHTGVKPFACTMCDMRFFQRYH-- 328

  Fly   471 TTPSGSSLPATAALNSLLQQRQANADGAAMFAASAMKNEVNVKMERSYSNSTSESSYSVQDSGYN 535
                             ||:......|...:|.                        |:.|..:.
Zfish   329 -----------------LQRHSITHTGVKPYAC------------------------SMCDMRFF 352

  Fly   536 NAYGSDSSMHAGAIAGPQAHSSTLDDSEDALCCVPLCGVRKSTSPTLQFFTFPKDEKYLNQWLHN 600
            :.|      |.      |.||.|....:...|  .:|.:|        ||     ::|..| .|:
Zfish   353 HRY------HL------QRHSLTHTGVKPYAC--TMCDMR--------FF-----QRYHLQ-RHS 389

  Fly   601 LKMFHIPAASYANFRICSMHFPKRC-INRYSLCYWAVPTFNLGHDDVANLYQNRELTNTFTTGEV 664
            |.  |.....|| ..:|.|.|.:|. :.|:||.:..|..:
Zfish   390 LT--HTGVKPYA-CSMCDMRFFQRYHLQRHSLTHTGVKPY------------------------- 426

  Fly   665 ARCSMPHCTSQRGESNLKFYNFPKDIKSLIKWCQNARLPVQAKEPRHFCSRHFEERCIGKFRLKP 729
             .|||                           |          :.|.|...|.|...:.....||
Zfish   427 -ACSM---------------------------C----------DMRFFQRYHLERHSLTHTGEKP 453

  Fly   730 WA--------VPTLHLGAQYGKIHDNPKNLYVEEKRCCLNFCRRSRSSDFNMSLYRFPRDEVLLR 786
            :|        :...|| .::.::|...|....|  ||..||.|..|                |||
Zfish   454 FACDMCDMRFIQRYHL-ERHKRVHSGEKPYQCE--RCQQNFSRTDR----------------LLR 499

  Fly   787 RWCYNLRLDPGVYRGKNHKICSAHFIKEALGLRKLSPGAVPTLHLGHTDTFNIYENELWPPPTAP 851
                            :.::|      :..|:.|:.....|            |..|   ||.||
Zfish   500 ----------------HRRLC------QGRGVTKVEAQPCP------------YTQE---PPPAP 527

Fly 852 851
Zfish 528 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	5/22 (23%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		DM3	584..642	CDD:128933	17/58 (29%)
		DM3	683..738	CDD:128933	9/62 (15%)
		DM3	775..832	CDD:128933	7/56 (13%)
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
znf740a	XP_005172837.1	COG5048	138..503	CDD:227381	105/547 (19%)
		C2H2 Zn finger	148..168	CDD:275368	5/20 (25%)
		C2H2 Zn finger	176..196	CDD:275368	8/19 (42%)
		C2H2 Zn finger	204..224	CDD:275368	4/19 (21%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		C2H2 Zn finger	288..308	CDD:275368	3/27 (11%)
		C2H2 Zn finger	316..336	CDD:275368	6/38 (16%)
		C2H2 Zn finger	344..364	CDD:275368	7/55 (13%)
		C2H2 Zn finger	372..392	CDD:275368	9/37 (24%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	428..448	CDD:275368	8/56 (14%)
		C2H2 Zn finger	456..476	CDD:275368	2/20 (10%)
		C2H2 Zn finger	484..503	CDD:275368	10/52 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100