DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10631 and znf366

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	XP_698186.3	Gene:	znf366 / 569695	ZFINID:	ZDB-GENE-110408-46	Length:	559	Species:	Danio rerio

Alignment Length:	614	Identity:	126/614 - (20%)
Similarity:	199/614 - (32%)	Gaps:	146/614 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 HQHQHLPQHISQQRPYMG---HNIMTGS--YPYIKSE-----PMEAYQQPPNPMAPP------PA 211
            |.|:..|:.|...|..:.   |.:..|.  ...:|.|     |.....:.|.|..||      |.
Zfish    31 HPHRFTPEMIDLSRLRLHRVLHTVKNGRDFNVQVKQELPLWPPSPLLLRSPAPYFPPFHPSLVPF 95

  Fly   212 PEVLIKSEPIDEHSYKSNYIDDNTPFADFSKFSEFSEDMLSPKVELTVKDESYGRTTSSFLRRKQ 276
            |.:|..|.|    :...|....:.||....:..:..|     |:.:.|.|..|........|.|
Zfish    96 PFLLPGSVP----NLSPNPFYPSEPFRVHRRPPDGPE-----KLNVHVDDSYYVDVGGDQKRWK- 150

  Fly   277 QSDRGNESLPICQRCKEVFFKKQVYLRHVAESNCGIQEYDFKCSTCPMSFMTTEELQRHKLHHRA 341
                       |:.|::.:..|...:.|:. .:.||:.:  .||.|...|.....|..|.|.|:.
Zfish   151 -----------CRMCEKSYTSKYNLITHIL-GHSGIKPH--ACSLCGKLFKQLSHLHTHMLTHQG 201

  Fly   342 DRFFCHKYCGKHFDTIAECEAHEYMQH-EYDSFVCNMCSGTFATREQLYAHLPQHKFQQRFDCPI 405
            .|....:.|.|.|...:..:.| .||| :...:.|::|...||...:|.||..:|:..|...|..
Zfish   202 TRPHKCQVCHKAFTQTSHLKRH-MMQHSDVKPYSCSVCGRGFAYPSELRAHELKHERGQENVCVE 265

  Fly   406 CRLWYQTALELHEHRLA-------APYFCGKYYTGGQSSSASQSQAQQHQTNYK------LQDCH 457
            |.|.:.|..:|..|..|       |...|||       |....||.|.|...:|      ..:|.
Zfish   266 CGLDFPTLAQLKRHLTAHRGPVQYACSECGK-------SFQYPSQLQNHMMKHKDIRPFICSECG 323

  Fly   458 MATMEMPTTPHHKTTPSGSSLPATAALNSLLQQRQANADGAAMFAASAMKNEVNVKME-RSYSNS 521
            |..::......|..|..|            :::.:....|......:.||..|.:... |:|...
Zfish   324 MEFVQSHHLKQHTLTHKG------------VKEHKCRICGREFTLLANMKRHVLIHTNIRAYQCE 376

  Fly   522 TSESSYSVQDSGYNNAYGSDSSMHAGAIAGPQAHSSTLDDSEDALCCVPLCG------------- 573
            ....|: ||....                  :||.....|.:...|  .|||
Zfish   377 LCYKSF-VQKQTL------------------KAHMIVHSDIKPYKC--KLCGKEFNRMHNLMGHM 420

  Fly   574 -VRKSTSPTLQFFTFPKDEKYLNQWLHNLKMFHIPAASYANFRIC------SMHFPKRCINRYSL 631
             :...:.|....:...|.....|...| :|:.|.......:.|:|      .:..|.|.::|
Zfish   421 HLHSDSKPFKCLYCASKFTLKGNLTRH-MKIKHGIMDQGLDARVCRRQGRLCLSGPLRILSR--- 481

  Fly   632 CYWAVPTFNLGHDDVANLYQNRELTNTFTTGEVARCSMPHCTSQRGESNLKFYNFPKDIKSLIKW 696
                     :|.|:..:|.|...|..:.:.||..|..    :|.|.|.....|.       :.::
Zfish   482 ---------IGQDEPFDLSQKNPLRLSQSDGESVRGG----SSSREEDEDSVYR-------MSQY 526

  Fly   697 CQNARLPVQA------KEPRHFCSRHFEE 719
            ..:...|.:|      |:..|....|.::
Zfish   527 SPDRENPAEARDQEDEKKTSHLAQIHSDK 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	4/22 (18%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		DM3	584..642	CDD:128933	10/63 (16%)
		DM3	683..738	CDD:128933	6/43 (14%)
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
znf366	XP_698186.3	C2H2 Zn finger	151..171	CDD:275368	4/20 (20%)
		C2H2 Zn finger	179..199	CDD:275368	7/19 (37%)
		zf-C2H2	205..227	CDD:278523	5/22 (23%)
		C2H2 Zn finger	207..227	CDD:275368	5/20 (25%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		COG5048	<288..431	CDD:227381	32/182 (18%)
		C2H2 Zn finger	291..311	CDD:275368	8/26 (31%)
		C2H2 Zn finger	319..339	CDD:275368	3/19 (16%)
		C2H2 Zn finger	347..367	CDD:275368	4/19 (21%)
		C2H2 Zn finger	375..395	CDD:275368	5/38 (13%)
		C2H2 Zn finger	403..423	CDD:275368	4/21 (19%)
		C2H2 Zn finger	431..450	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591920
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930