DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10631 and pita

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	98/500 - (19%)
Similarity:	161/500 - (32%)	Gaps:	150/500 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 PYIKSEPMEAYQQPPNPMAPPPA----------------PEVLIKSEPIDEHSYKSNYIDDNTPF 237
            |...:||.|..::..|.||...:                |..:..|.|:...|:......||...
  Fly   122 PAKTAEPSETPKKLLNTMAKSSSQVIIEDVQVLESAMVTPRTVAGSSPVPRRSHAYELKVDNNQE 186

  Fly   238 ADFSKFSEFSEDMLS---------PKVELTVKDESYGRTTSSFLR--------------RKQQSD 279
            ..........|||.|         |:....||.:...:::...|.              :.::.|
  Fly   187 LSMDDVQSMLEDMASELEKEFPDIPQKASPVKPKVLNKSSIRILNKGPAAPVEPRLATPKVKRDD 251

  Fly   280 RGN---------ESLPI-------------------CQRCKEVFFKKQVY----LRHVAESNCGI 312
            .||         ..||:                   |..|:..|..:|:.    |.|.
  Fly   252 SGNVAIVTEVLDSDLPLDDQDDPTKNAEKVATDVFPCPDCERSFPLQQLLEIHRLNHT------- 309

  Fly   313 QEYDFKCSTCPMSFMTTEELQRHKLHHRADRFFCHKYCGKHFDTIAECEAHEYMQHEYDSFVCNM 377
            :...|:|..|..||.:..:|.:|...|..:|.|....|.|.|...|....||....:...|:|..
  Fly   310 RSRSFQCLLCEKSFFSKYDLAKHNFVHTGERPFKCAICSKAFTRKALLHRHERTHTDVPKFICVY 374

  Fly   378 CSGTFATREQLYAHLPQHKFQQRFDCPIC--RLWYQTALELHE--HRLAAPYFCGKYYTGGQSSS 438
            |...|.:|:::..|..:|:.::.|.|.:|  ...::..||.||  |....|:.|...    :.|.
  Fly   375 CEKPFLSRQEMEKHAERHQKKRPFQCGVCTKSFAFKQGLERHETVHSTNLPFPCQHC----ERSF 435

  Fly   439 ASQSQAQQH------QTNYKLQDCHMATMEMPTTPHH-------KTTPSGSSLPAT------AAL 484
            ::.|:..:|      :..|..:.||.:.|    ..||       .|..|.:|...:      :..
  Fly   436 STASKLARHLVAHAGKRAYPCKYCHKSYM----LSHHLSRHLRTHTQTSDASFVCSECKVSYSNY 496

  Fly   485 NSLLQQRQANADGAAMFAASAMK-----------NEVNVKMERSYSNSTS--------------- 523
            |.||       |.|.:.|.:::|           :.|...|::...:...
  Fly   497 NDLL-------DHALIHATASLKCPMCRKQIEDIDSVESHMDQHKQSERHACEFCDHIFLTQKCL 554

  Fly   524 ----ESSYSVQDSGYNNAYGSDSSMHAGAIAGPQAHSSTLDDSED 564
                |..:.|:...|.|.: .|.....|.:...:.|   |||.||
  Fly   555 QRHIEDDHVVEMEPYQNEF-EDDGEGEGGVDEKEEH---LDDFED 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	6/26 (23%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		DM3	584..642	CDD:128933
		DM3	683..738	CDD:128933
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
pita	NP_611806.3	zf-AD	17..92	CDD:214871
		COG5048	<281..506	CDD:227381	56/246 (23%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	8/24 (33%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..388	CDD:275370	4/15 (27%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	4/23 (17%)
		C2H2 Zn finger	456..476	CDD:275368	5/23 (22%)
		C2H2 Zn finger	486..506	CDD:275368	5/26 (19%)
		HARE-HTH	<566..625	CDD:294801	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100