DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10631 and Kr-h1

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	715	Identity:	156/715 - (21%)
Similarity:	227/715 - (31%)	Gaps:	168/715 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LNVSGAVVGGGGPNYGLGANTVAYAHNQLLQYQQQQQQQQQQQQQQQQQHQ---------HQHLP 169
            |..:...||.|.|..| |..    .|.:|||..||:|.|.|.|.|.||:.|         .||..
  Fly    83 LTATTTSVGLGVPPSG-GQQ----EHFELLQTPQQRQMQLQLQDQHQQEQQQFVSYQLAIQQHQK 142

  Fly   170 QHISQQRPYMGHNIMTGSYP-------YIKSEPMEAY-------QQPPNPMAPPPAPEVLIKSEP 220
            |...||     |..:|.:.|       .||:||:..:       .|...|.|..|..:.......
  Fly   143 QQQQQQ-----HESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSASKPQFKCDQCGMT 202

  Fly   221 IDEHSYKSNYIDDNTPFADFSKFSEFSEDMLSP----KVELTVKDESYGRTTSSFLRRKQQSDRG 281
            ....|..:::...::...|.|........:.:|    .:||.......|...|..::.......|
  Fly   203 FGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAG 267

  Fly   282 NESLPICQRCKEVFFKKQVYLRHVAESNCGIQEYDFKCSTCPMSFMTTEELQRHKLHHRADRFFC 346
            .:... |..|::.|......:||. .::.|  |..|:|..|...|...|.||.|:..|..:|.:.
  Fly   268 ADPYQ-CNVCQKTFAVPARLIRHY-RTHTG--ERPFECEFCHKLFSVKENLQVHRRIHTKERPYK 328

  Fly   347 HKYCGKHFDTIAECEAHEYMQHEYDSFVCNMCSGTFATREQLYAHLPQHKFQQRFDCP------- 404
            ...||:.|:...:...|..:........|::|..||....||..|:..|..::.:.||
  Fly   329 CDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKG 393

  Fly   405 -ICRLWYQTALELHE--HRLAAPYFCGKYYTGGQSSSASQSQAQQHQTN--YKLQDC-----HMA 459
             .|    ...|::|.  |....||.|...:.....:...:....||..:  ||...|     :..
  Fly   394 FTC----SKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKK 454

  Fly   460 TMEMPTTPHHKTTPSGSSLPATAALNSLLQQRQANADGAAMFAASAMKNEVNVKMERSYSNSTSE 524
            .||.....|....|..                  .|:.||..||:            |.|..:|.
  Fly   455 EMEAHIKGHANEVPDD------------------EAEAAAASAAA------------STSAGSSA 489

  Fly   525 SSYSVQDSGYNNAYGSDSSMHAGAIAGP------QAHSSTLDDSEDALCCVPLCGVRKSTSPTLQ 583
            .|.|:|....|    |:||.|:...:.|      ||....:..:..|...:|   .....||:
  Fly   490 GSPSLQGVSSN----SESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIP---TSSPLSPS-- 545

  Fly   584 FFTFPKDEKYLNQWLHNLKMFHIPAASYANFRICSMHFPKRCINRYSLCYWAVPTFNLGHDDVAN 648
                            :|...:.|:||       ||..|......|.........  |..|...:
  Fly   546 ----------------SLSSTYSPSAS-------SMASPPPTSAHYLPVQMEADA--LSRDSGVS 585

  Fly   649 LYQNRELTNTFTTGEVARCSMPHCTSQRGESNLKFYNFPKDIKSLIKWCQNARLPVQAK--EPRH 711
            ..|...  :|:...|....||.....|..||.:.:|..|..:..|..  |.|.|.:...  |...
  Fly   586 SAQPAH--STYADEEPTDLSMQQVQGQLPESTVDYYQAPPSLLELQP--QPAGLTINPALLEAAS 646

  Fly   712 FCSRHFE------------------ERCIGKFRLKPW---------AVPTLH---LGAQYGKIHD 746
            ...||.:                  :.|.|...|.|.         .|||||   |.|.|...|:
  Fly   647 IARRHDDNDDQVQDEDVHAAAWQMMQLCRGHGSLPPTEQPAPSHQPQVPTLHVSDLAANYDDTHE 711

Fly 747 746
Fly 712 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	5/22 (23%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		DM3	584..642	CDD:128933	8/57 (14%)
		DM3	683..738	CDD:128933	18/86 (21%)
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	1/19 (5%)
		COG5048	<270..420	CDD:227381	38/157 (24%)
		zf-C2H2	271..293	CDD:278523	5/23 (22%)
		C2H2 Zn finger	273..293	CDD:275368	5/20 (25%)
		zf-H2C2_2	286..309	CDD:290200	7/25 (28%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	313..338	CDD:290200	8/24 (33%)
		C2H2 Zn finger	329..349	CDD:275368	4/19 (21%)
		zf-H2C2_2	344..366	CDD:290200	5/21 (24%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..396	CDD:290200	5/25 (20%)
		C2H2 Zn finger	385..407	CDD:275368	5/25 (20%)
		zf-H2C2_2	400..424	CDD:290200	6/23 (26%)
		C2H2 Zn finger	415..435	CDD:275368	1/19 (5%)
		zf-C2H2	441..463	CDD:278523	5/21 (24%)
		C2H2 Zn finger	443..463	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100