DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10631 and ZNF524

DIOPT Version :9

Sequence 1:NP_609998.1 Gene:CG10631 / 35262 FlyBaseID:FBgn0032817 Length:3781 Species:Drosophila melanogaster
Sequence 2:XP_011524789.1 Gene:ZNF524 / 147807 HGNCID:28322 Length:370 Species:Homo sapiens


Alignment Length:247 Identity:54/247 - (21%)
Similarity:83/247 - (33%) Gaps:47/247 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 AYQQPPNPMAPPPAPEVLIKSEPIDEHSYKSNYIDDNTPFADFSKFSEFSEDMLSPKVELTVKDE 262
            |..|.|:.....|:|:.|....|.:|..          |.|            |||.|....:..
Human    98 AQTQAPHCSMDTPSPDPLPSPLPGEEEK----------PLA------------LSPPVPRGRRGR 140

  Fly   263 SYGRTTS-------SFLRRKQQSDRGNESLPICQ------------RCKEVFFKKQVYLRHVAES 308
            ..|..||       |..|::.:..:..:..|:.|            ....:....|.....|:|.
Human   141 RPGGATSSNRTLKASLPRKRGRPPKSGQEPPLVQVQGVTAPVGSSGGSDLLLIDDQGVPYTVSEG 205

  Fly   309 NC------GIQEYDFKCSTCPMSFMTTEELQRHKLHHRADRFFCHKYCGKHFDTIAECEAHEYMQ 367
            :.      |.::....|..|..:|....:|:||.:.|...:....|.|||.|...:....|..:.
Human   206 SAAGPEGSGPRKAPHFCPVCLRAFPYLSDLERHSISHSELKPHQCKVCGKTFKRSSHLRRHCNIH 270

  Fly   368 HEYDSFVCNMCSGTFATREQLYAHLPQHKFQQRFDCPICRLWYQTALELHEH 419
            .....|.|.:|...|....:|..|...|..::.:.||||||.:..|..|..|
Human   271 AGLRPFRCPLCPRRFREAGELAHHHRVHSGERPYQCPICRLRFTEANTLRRH 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10631NP_609998.1 C2H2 Zn finger 288..311 CDD:275368 4/40 (10%)
C2H2 Zn finger 319..339 CDD:275368 6/19 (32%)
DM3 584..642 CDD:128933
DM3 683..738 CDD:128933
DM3 775..832 CDD:128933
DM3 945..1000 CDD:128933
DM3 1038..1096 CDD:128933
DM3 1145..1198 CDD:128933
THAP 1236..1308 CDD:214951
DM3 1349..1406 CDD:128933
THAP 1424..1493 CDD:214951
DM3 1538..1596 CDD:128933
DM3 1683..1739 CDD:128933
DM3 1778..1831 CDD:128933
DM3 1980..2033 CDD:128933
DM3 2147..2202 CDD:128933
DM3 2308..2365 CDD:128933
DM3 2434..2491 CDD:128933
DM3 2539..2598 CDD:128933
DM3 2622..2680 CDD:128933
DM3 2718..2775 CDD:128933
DM3 2907..2965 CDD:128933
DM3 3098..3155 CDD:128933
DM3 3227..3284 CDD:128933
DM3 3396..3452 CDD:128933
DM3 3544..3601 CDD:128933
THAP 3621..>3669 CDD:283206
DM3 3690..3748 CDD:128933
ZNF524XP_011524789.1 COG5048 <219..>283 CDD:227381 16/63 (25%)
C2H2 Zn finger 222..242 CDD:275368 6/19 (32%)
zf-H2C2_2 234..259 CDD:290200 9/24 (38%)
C2H2 Zn finger 250..270 CDD:275368 6/19 (32%)
zf-H2C2_2 262..285 CDD:290200 4/22 (18%)
C2H2 Zn finger 278..298 CDD:275368 5/19 (26%)
zf-H2C2_2 290..314 CDD:290200 9/23 (39%)
C2H2 Zn finger 306..327 CDD:275368 9/17 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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