DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10631 and ZNF358

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	NP_060553.4	Gene:	ZNF358 / 140467	HGNCID:	16838	Length:	568	Species:	Homo sapiens

Alignment Length:	467	Identity:	104/467 - (22%)
Similarity:	157/467 - (33%)	Gaps:	118/467 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 EPMEAYQQPPNPMAPPPAPEVLIKSEPIDEHSYKSNYIDDNTPFADFSKFSEFSEDMLS---PKV 255
            |.:|...:..:|.|..|.      |||.|.....|::..|...........:.:.|.||   |||
Human    62 EDLEPVSEDLDPDAEAPG------SEPQDPDPMSSSFDLDPDVIGPVPLILDPNSDTLSPGDPKV 120

  Fly   256 E-----LTVKDE----------------------SYGRT--TSSFLRRKQQSDRGNESLPICQRC 291
            :     ||...:                      ..||.  .||.|.:.:::..|.:... |..|
Human   121 DPISSGLTATPQVLATSPAVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYR-CPDC 184

  Fly   292 KEVFFKKQVYLRHVAESNCGIQEYDFKCSTCPMSFMTTEELQRHKLHHRADRFFCHKYCGK---- 352
            .:.|.......:| ...:.|.:.|  :|:.|..:|.....|.:|:..|..::......|||
Human   185 GKSFSHGATLAQH-RGIHTGARPY--QCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGH 246

  Fly   353 ------HFDTIAECEAHEYMQHEYDSFVCNMCSGTFATREQLYAHLPQHKFQQRFDCPIC--RLW 409
                  |..|......|:          |.:|:..|.....|..||..|..::.:.||.|  ...
Human   247 GSLLAQHLRTHGGPRPHK----------CPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFG 301

  Fly   410 YQTALELHE--HRLAAPY---FCGKYYTGGQSSSA----------------------SQSQA-QQ 446
            ..:||..|:  |....||   .|||.:  ||||:.                      .||.| .|
Human   302 QSSALLQHQRTHTAERPYRCPHCGKAF--GQSSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQ 364

  Fly   447 H------QTNYKLQDCHMATMEMPTTPHHKTTPSGSSLPATAALNSLLQQRQANADGAAMFAASA 505
            |      :..|:.|.|..|..:..:...||....|::..|.||..:..........|..:..||.
Human   365 HLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAAAAAGLGLGPGLSPASM 429

  Fly   506 MK-NEVNVKMERSYSNSTSESSYSVQDSGYNNAYGSDSSMHAGAIAGPQAHSSTLDDSEDALCCV 569
            |: .:|::         ....:.||..||...:.|:.|..:....:||    .||.|....
Human   430 MRPGQVSL---------LGPDAVSVLGSGLGLSPGTSSGRNPDPGSGP----GTLPDPSSK---- 477

  Fly   570 PLCGVRKSTSPT 581
            ||.|.|.:.|||
Human   478 PLPGSRSTPSPT 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	4/22 (18%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		DM3	584..642	CDD:128933
		DM3	683..738	CDD:128933
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
ZNF358	NP_060553.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117		14/60 (23%)
		COG5048	<35..339	CDD:227381	66/298 (22%)
		lambda-1	108..>174	CDD:212564	13/65 (20%)
		zf-C2H2	151..173	CDD:278523	5/21 (24%)
		C2H2 Zn finger	153..173	CDD:275368	5/19 (26%)
		zf-H2C2_2	166..190	CDD:290200	5/24 (21%)
		C2H2 Zn finger	181..201	CDD:275368	4/20 (20%)
		zf-H2C2_2	194..216	CDD:290200	5/24 (21%)
		C2H2 Zn finger	209..229	CDD:275368	5/19 (26%)
		zf-H2C2_2	222..244	CDD:290200	6/21 (29%)
		C2H2 Zn finger	237..257	CDD:275368	4/19 (21%)
		zf-H2C2_2	250..272	CDD:290200	5/31 (16%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..300	CDD:290200	7/22 (32%)
		zf-C2H2_8	292..370	CDD:292531	21/79 (27%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		zf-H2C2_2	305..328	CDD:290200	9/22 (41%)
		C2H2 Zn finger	321..341	CDD:275368	7/21 (33%)
		zf-H2C2_2	333..356	CDD:290200	0/22 (0%)
		C2H2 Zn finger	349..369	CDD:275368	5/19 (26%)
		zf-H2C2_2	361..384	CDD:290200	6/22 (27%)
		zf-C2H2	375..397	CDD:278523	6/21 (29%)
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..568		16/50 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100