DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10631 and Zfp366

DIOPT Version :9

Sequence 1:	NP_609998.1	Gene:	CG10631 / 35262	FlyBaseID:	FBgn0032817	Length:	3781	Species:	Drosophila melanogaster
Sequence 2:	XP_038959405.1	Gene:	Zfp366 / 100360041	RGDID:	2322904	Length:	743	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	159/766 - (20%)
Similarity:	254/766 - (33%)	Gaps:	224/766 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VASYP---TPHSAFGPAPA--PSCKAANNSGSGNNNNNIMGGGGYGPGGGGAQGYYGAAGGGLNV 116
            :.|:|   .|.::.|.||.  |..:|..                    |..:|..|..:.|.|:.
  Rat    22 IPSFPHCLQPEASRGKAPQRHPFPEALR--------------------GPFSQFRYEPSPGDLDG 66

  Fly   117 SGAVVGGGGPNYGLGANT-VAYAH-----------------NQLLQYQQQQQQQQQQQQQQ---- 159
            ...|..|||........| |.|.|                 |..|.:.|.|..:...|...
  Rat    67 FPEVFEGGGSRKRKSMPTKVPYNHSAEEATIAQESKSLGPPNLALLFPQPQHPKCDSQMIDLCNV 131

  Fly   160 --QQQHQHQHLPQHISQQRPYMGHNIMTGSYPYIKSEPMEAYQQPPNPMAPPPAPEVLIKSEPID 222
              |.....:||                 |..| :|.||::     |:.|.|.|.|...:.:
  Rat   132 GLQFYRTLEHL-----------------GGKP-VKQEPVK-----PSAMWPQPTPPAFLPA---- 169

  Fly   223 EHSYKSN---------YIDDNTPFADFSKFS----EFSEDMLSPKVELTVKDESYGRTTSSFLRR 274
            .:.|...         ::..::|| .||:.:    :..|.:|..|||....:|:
  Rat   170 PYPYYPKVHPGLMFPFFMPSSSPF-PFSRHTFLPKQPPEPVLPRKVEPLESEET----------- 222

  Fly   275 KQQSDRGNESLPI----------------CQRCKEVFFKKQVYLRHVAESNCGIQEYDFKCSTCP 323
            ||:.:|.:.::.|                |..|.:.:..|...:.|:. .:.||:.:  .||.|.
  Rat   223 KQKVERVDVNVQIDDSYYVDVGGAQKRWQCPTCDKSYTSKYNLVTHIL-GHSGIKPH--ACSRCG 284

  Fly   324 MSFMTTEELQRHKLHHRADRFFCHKYCGKHFDTIAECEAHEYMQH-EYDSFVCNMCSGTFATREQ 387
            ..|.....|..|.|.|:..|....:.|.|.|...:..:.| .||| |.....|.:||..||...:
  Rat   285 KLFKQLSHLHTHMLTHQGTRPHKCQVCHKAFTQTSHLKRH-MMQHSEVKPHNCRVCSRGFAYPSE 348

  Fly   388 LYAHLPQHKFQQRFDCPICRLWYQTALELHE----HRLAAPYFCGKYYTGGQSSSASQSQAQQHQ 448
            |.||..:|...:...|..|.|.:.|..:|..    ||....|.|.:.....|..|..|:...:|:
  Rat   349 LKAHEAKHASGRENICVECGLDFPTLAQLKRHLTTHRGPIQYNCSECDKTFQYPSQLQNHMMKHK 413

  Fly   449 --TNYKLQDCHMATMEMPTTPHHKTTPSGSSLPATAALNSLLQQRQANADGAAMFAASAMKNEVN 511
              ..|...:|.|..::    |||        |...:..:..:::.:....|......:.||..|.
  Rat   414 DIRPYICSECGMEFVQ----PHH--------LKQHSLTHKGVKEHKCGICGREFTLLANMKRHVL 466

  Fly   512 VKME-RSYSNSTSESSYSVQDSGYNNAYGSDSSMHAGAIAGPQAHSSTLDDSEDALCCVPLCGVR 575
            :... |:|.......|: ||....                  :||.....|.:...|  .|||
  Rat   467 IHTNIRAYQCHLCYKSF-VQKQTL------------------KAHMIVHSDVKPFKC--KLCG-- 508

  Fly   576 KSTSPTLQFFTFPKDEKYLNQWLHNLKMFHIPAASYANFRICSMHFPKRCI---NRYSLCYWAVP 637
                            |..|: :||| |.|:...|.:.        |.:|:   ::::|
  Rat   509 ----------------KEFNR-MHNL-MGHLHLHSDSK--------PFKCLYCPSKFTL------ 541

  Fly   638 TFNL-GHDDVANLYQNR----------ELTNTFTTGEVARCSM--PHCTSQRGESNLKFYNFPKD 689
            ..|| .|..|.:....|          .|....:||.:.....  |...||:  .:.|...|..|
  Rat   542 KGNLTRHMKVKHGVMERGLHSQGLGRGRLVLAQSTGALRNLEQEEPFDLSQK--RSAKGPMFQSD 604

  Fly   690 IKSLIKWCQNARLPVQAKEPRHFCSRHFEERCIGKFRLKPWAVPTLHLGAQ 740
            :.|    .|....|.:.:|.......  |::|   :.::|:: |||.|.:|
  Rat   605 MDS----TQGCLYPEEEEEEEEEADE--EDKC---YDVEPYS-PTLALESQ 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368	4/22 (18%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		DM3	584..642	CDD:128933	13/61 (21%)
		DM3	683..738	CDD:128933	12/54 (22%)
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933
		DM3	1980..2033	CDD:128933
		DM3	2147..2202	CDD:128933
		DM3	2308..2365	CDD:128933
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3621..>3669	CDD:283206
		DM3	3690..3748	CDD:128933
Zfp366	XP_038959405.1	PRK10263	<51..>227	CDD:236669	43/214 (20%)
		COG5048	250..>546	CDD:227381	80/366 (22%)
		C2H2 Zn finger	252..272	CDD:275368	4/20 (20%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	5/20 (25%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	4/19 (21%)
		C2H2 Zn finger	420..440	CDD:275368	6/31 (19%)
		C2H2 Zn finger	448..468	CDD:275368	4/19 (21%)
		C2H2 Zn finger	476..496	CDD:275368	5/38 (13%)
		C2H2 Zn finger	504..524	CDD:275368	11/41 (27%)
		C2H2 Zn finger	532..551	CDD:275368	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930