DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10462 and wiza

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	XP_009300443.1	Gene:	wiza / 556689	ZFINID:	ZDB-GENE-030131-5663	Length:	995	Species:	Danio rerio

Alignment Length:	919	Identity:	181/919 - (19%)
Similarity:	304/919 - (33%)	Gaps:	324/919 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 ESEDNPNPKHCDICQYKFKSQQDISSHRVHHEMNLHFCRLG------CGIWLDTLEKILEH---- 123
            :.|.:.....|:.|...|:::..:|||     ...|..:||      .|..:|.|.|:::.
Zfish    27 KDESDSGIHSCEFCGTNFETRPGLSSH-----ARFHLRQLGVAVSDSSGAPIDLLSKLMKERGGT 86

  Fly   124 --EYRQHFQPGRVLCCRVCDFMANS--------ADDLASHMQK-------HIYVYRFVCSICRRH 171
              ::::..:|       |..:...|        ...|.||:.|       .|.:...|
Zfish    87 LPKFKKQAKP-------VKKYKHKSQVKAKPAKKSKLPSHILKKKPGPKLKIKISNIV------- 137

  Fly   172 FESKQSLNLHRKQSQDFCSL--LDFRKGSSSK--PELVAVSTPV----------------PEESN 216
             :.|.:|:.....|....||  |.|..|.:||  .:.:.||:||                |..|.
Zfish   138 -KKKYALSSSSAPSAVKGSLAGLTFAVGKTSKKSSKKIVVSSPVASSLPKALESRIGDSSPSTSL 201

  Fly   217 CYVQIKEEPLNAEEADRMLLEDNPPLNVKLEPQDEEMPDV---------------------SRIK 260
            .....|  ||.|.:      |.:.|||:.......:..||                     |.::
Zfish   202 SLASAK--PLWAPQ------ETDAPLNLTTMTNSTKREDVHVCELCGAWYETRKGLSSHARSHLR 258

  Fly   261 E----EQSNGSVWTAIHTPLRNK----------LRLPAL--------------ATTKN----QMH 293
            :    ..|.|:....:|..::::          |.:|.:              :|:||    .:.
Zfish   259 QFGVHLDSKGAPIELLHKIIQSEDFQEKASAGLLDIPDIKDRTSLTSVPSTSSSTSKNPSPSSLV 323

  Fly   294 LK---------PGVKR--------NGLLT------SNVESLNKKSNHSVISDD--ANIPISNQ-- 331
            ||         |.||:        ..||:      |.|.:..||     ||.|  .|:|:|.|
Zfish   324 LKGLTSIRIIPPSVKKQKTSLDVSGNLLSKKAQFKSTVSAKKKK-----ISQDFSGNMPLSGQTE 383

  Fly   332 --EPS--NSSIAANILKVLP-SNCMVIKLPPNTKIFKTPGQAPAAPKDSPTVTLSGTE-NSTNFI 390
              .||  ...::.::|.:|| |.....|..|..|     .|..:|........:..|| .||..:
Zfish   384 LKSPSRKKKKLSPDVLSILPVSGKAESKSSPPAK-----KQKVSADVSEALPLIEKTELKSTPSV 443

  Fly   391 KIPKTISISTVG-SMGNPHASAKTVQPTQTHSRSSCFLVDSFNNSKSRPESMKIINEFRNQIRSI 454
            |..|..|.::.. |:|: .|..|    ::.|..||..:...|.:.|.: :|..:.:..|..:|.:
Zfish   444 KKCKISSDASASLSLGD-QAEFK----SRCHGESSKTVKCDFCHEKFK-KSQSLASHARYHLRQL 502

  Fly   455 EKT-LPLPGTVLQSSKVTMDESTSS--PMDAPKPVEL--MLNPSA------LMVARELEIQYPLY 508
            ..| ..:.|:.:.:.:..|.:..:|  .:...:|..|  :|:|||      |::|.|.....|.
Zfish   503 GITEWSVKGSPMATLREVMAQRAASAGSLSTLEPPSLTPLLSPSATPSAPPLLLAPEPPSSSPR- 566

  Fly   509 RFMWTCPLCQRMFEKHCAFRAHLTNKHDLTDEKCNVLKVVLMPSKILSQDSANAATQRVHVPLNP 573
                  |:..::.:....||   |......||     .|.:..|.|.|..|.:|          |
Zfish   567 ------PVPHKVPKAKKGFR---TVNPKPKDE-----PVEVDVSNIESSKSQSA----------P 607

  Fly   574 QTPVPPPELPNTVNLPLLLSKTSAPLTGQTSALSNVPVNKGLSPTSINIEKPKVSKKPKKNQSFQ 638
            .||:.|....|.|..|::.:||.                               :::||  |...
Zfish   608 ITPLTPLSDSNAVKSPVIAAKTE-------------------------------NQEPK--QFVC 639

  Fly   639 CTECLKVFTTFGALRIHKSIHTGEL---------PYQCSYCDKRFRTPGQVRVHHRRH------- 687
            |..|.::|.|..||..|...|..:|         |.:..:  :..|..|.||....:.
Zfish   640 CDYCGEMFDTRKALSCHARSHLRQLGAKWSLKFPPIEALH--ELMRREGTVRASQIKPESALGAP 702

  Fly   688 ------------------TGEKP-------FKCKICSLDFTHRETLISHLSRHIGMK--RYKCYG 725
                              ..:||       ..|::|..||.:|:.|.||...|:..:  .:|.:|
Zfish   703 VQIKKKAITPPKLTLSPVENKKPEDGAGCDATCELCGFDFENRKALASHARAHLRQQGVDWKVHG 767

  Fly   726 CDKYFVVVSGLRAHRRLRPDTCGKVKFTARAHGPRVRVIRGEVVFQYHPEHNGYLRSEDPLNILS 790
            ..     :..|.|..:..|....::                         |..|:|.:.|  .:.
Zfish   768 SP-----IETLMAWMKSEPQKVAEL-------------------------HKSYMRGQLP--FVK 800

  Fly   791 QRDQTNSTP 799
            :..:..|||
Zfish   801 KVPRKTSTP 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	6/34 (18%)
		C2H2 Zn finger	165..186	CDD:275371	2/20 (10%)
		C2H2 Zn finger	639..659	CDD:275368	7/19 (37%)
		zf-H2C2_2	651..676	CDD:290200	6/33 (18%)
		C2H2 Zn finger	667..687	CDD:275368	4/19 (21%)
		zf-H2C2_2	680..704	CDD:290200	8/55 (15%)
		C2H2 Zn finger	695..715	CDD:275368	8/19 (42%)
		C2H2 Zn finger	723..742	CDD:275368	3/18 (17%)
wiza	XP_009300443.1	PBP1	<821..994	CDD:227507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100