DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10462 and Zfp644

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	XP_006535146.1	Gene:	Zfp644 / 52397	MGIID:	1277212	Length:	1363	Species:	Mus musculus

Alignment Length:	842	Identity:	165/842 - (19%)
Similarity:	259/842 - (30%)	Gaps:	299/842 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SEDNPNPKHCDICQYKFKSQQDISSHRVHH-EMNLHF----------CRLGCG------------ 111
            |.:.|:...|..|...|:.::.:..|.::| :.|.||          || .||
Mouse   404 STEEPSFYPCTKCNVNFREKKHLHRHMMYHLDGNSHFRHLNVPRPYACR-ECGRTFRDRNSLLKH 467

  Fly   112 --IWLDTLEKILE--HEYRQHFQPGRV--LCCRVCDFMANSADDLASHMQKHIYVYR-FVCSICR 169
              |..:..:|::|  .|.::....||.  |.|..|.|..|.......|.:.|....| :.|..|.
Mouse   468 MIIHQERRQKLMEEIRELKELQDEGRSARLQCPQCVFGTNCPKTFVQHAKTHEKDKRYYCCEECN 532

  Fly   170 RHFESKQSLNLHR-------------------KQSQDFCSLLDFRKGSSSKP-ELVAVSTPVPEE 214
            ....::..|..||                   :::|...|:.|...|||.|| ..:....|....
Mouse   533 FMAVTENELECHRGIAHGAAVKCPVVSSEVTQRKTQKKTSVKDSVIGSSKKPATYLCKMCPFTTS 597

  Fly   215 SNCYVQIKEEPLNAEE-ADRMLLEDNPPLNVKLEPQD--EEMPDVSRIKEEQSNGSVWTAIHTPL 276
            :...::...|.|::.. .|..    ..||.:.....|  ||..||...|.        .|...|
Mouse   598 ARSILKKHTEYLHSSACVDSF----GNPLGLDKRKNDSLEESVDVDSTKS--------LAKQQP- 649

  Fly   277 RNKLRLPALATTKNQMHLKPGVKR---NGLLTSNVESLNK------KSNHSVISDDANIPISNQE 332
                     :|......||...||   :...:||....:|      |:..|:.....|....|:.
Mouse   650 ---------STFPKNSALKQDAKRTFGSSSQSSNFSKFHKRPHRIQKARKSIAQSGVNSCSQNKS 705

  Fly   333 PSNSSIAANILKVLPSNCMVIKLPPNTKIF-KTPGQAPAAPKDSP-----------TVTLSGTEN 385
            |..:.:..:.....|            |.| :.|.:.|.|..||.           |:..||...
Mouse   706 PHKNVMVKSSTDQQP------------KYFHQAPREKPNARADSSYLYRHKYNNYRTIRKSGDSY 758

  Fly   386 STNFIKIPKTISISTVGSMGNPHASAKTVQPTQTHSRSSCFLVDSFNNSKSRPESMKIINEFRNQ 450
            ...|.|        .|.|:.:.|..:.        |.|..|:.|..|....|||:.|  :..|..
Mouse   759 PLPFKK--------EVNSLNSLHLFSS--------SNSHNFISDPHNADTKRPENEK--DHKRVA 805

  Fly   451 IRSIEKTLPLPGTVLQSSKVTMDESTSSPMDAPKPVELMLNPSALMVARELEIQYPLYRFMWTCP 515
            ::.:.|          :||  .:.|....:|:                      ||.:....|..
Mouse   806 VKRVAK----------ASK--KESSAGEDLDS----------------------YPDFLHKMTVV 836

  Fly   516 LCQRMF-EKHCAFRAHLTNK-------------------HDLTDEKCNVLKVVLMPSKILSQ--- 557
            :.|::. :|..::.....:.                   .||:.|..|:|.  |..|||..|
Mouse   837 VLQKLHSDKKDSYETEDDSSWDNVELGDYTTQAMEEEAYSDLSQEHVNLLP--LFKSKIEGQGPG 899

  Fly   558 DSA--------------------NAATQRVHVPL---NPQTPVPPPELPNTVNLPLLLSKTSAPL 599
            |||                    |:..|.:|.|.   ||:||               |||.|:..
Mouse   900 DSAALSYDQNDGFYFEYYEDGGTNSFLQDIHDPQHLENPETP---------------LSKHSSVF 949

  Fly   600 TGQTSALSNVPVNKGLSPTSINIEKPKVSKKPKKNQSFQCTECLKVFTTFGALRIH--KSIHTGE 662
            ..                |.:::||.            .|..|...|.|...|..|  ..:|...
Mouse   950 HW----------------TDLSLEKK------------SCPYCPATFETGVGLSNHVRGHLHRAG 986

  Fly   663 LPYQCSYCDKRFRTPGQV----RVHHRRHTGE-KPFK----------------CKICSLDFTHRE 706
            |.|:.    :...:|.|:    ::.|.:.||. .|.|                |::|...|..:.
Mouse   987 LSYEA----RHVVSPEQIATSDKMQHFKRTGNGTPVKRVRKAIEKSETTSEHTCQLCGGWFDTKI 1047

  Fly   707 TLISHLSRHIGMKR--------YKCYGC---------DKYFVVVSGLRAHRRL-RPDTCGKV 750
            .|.:|:..|  :||        :|...|         :||..::..|.:.|.: ||....|:
Mouse  1048 GLSNHVRGH--LKRLGKTKWDAHKSPICVLNEMMQNEEKYEKILKALNSRRIIPRPFVAQKL 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	5/19 (26%)
		C2H2 Zn finger	165..186	CDD:275371	5/39 (13%)
		C2H2 Zn finger	639..659	CDD:275368	6/21 (29%)
		zf-H2C2_2	651..676	CDD:290200	5/26 (19%)
		C2H2 Zn finger	667..687	CDD:275368	3/23 (13%)
		zf-H2C2_2	680..704	CDD:290200	8/44 (18%)
		C2H2 Zn finger	695..715	CDD:275368	5/19 (26%)
		C2H2 Zn finger	723..742	CDD:275368	5/27 (19%)
Zfp644	XP_006535146.1	C2H2 Zn finger	413..433	CDD:275370	4/19 (21%)
		zf-C2H2	449..471	CDD:395048	4/22 (18%)
		C2H2 Zn finger	451..471	CDD:275370	4/20 (20%)
		C2H2 Zn finger	499..519	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100