DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10462 and dar1

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	663	Identity:	130/663 - (19%)
Similarity:	206/663 - (31%)	Gaps:	227/663 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 ADDLASHMQKHIYVYRFVCSICRRHFESKQSLNLHRKQSQDFCSLLDFRKGSSSKPELVAVSTPV 211
            ||.|....|:.:.......||  ::.:.:.:|.|....|.:       ..|||:.      |:..
  Fly   219 ADPLDDPYQRPVLWDDITTSI--QNIDPENALMLSSSGSSN-------NNGSSNS------SSNT 268

  Fly   212 PEESNCYV-QIKEEPLNAEEADRMLLE--DNP---PLNVKLE----------PQDEEMPDVSRIK 260
            .|.:...: |:|.|.:     |..|||  ..|   ||.:|.|          .|.::.....:.:
  Fly   269 GESATSQLPQVKMEAI-----DESLLETFSTPLLSPLEIKTEKQQRQQQHQHQQQQQQQQQQQQQ 328

  Fly   261 EEQSNGSVWTAIHTPLRNKLRLPALATTKNQMHL---KPGVKRNGLLTS-NVESLNKKSNHSVIS 321
            .:|.:...:...|.....:           |.||   .|.:...||..: :|..|..:..|   .
  Fly   329 HQQQHQQQYQQQHYQQHYQ-----------QQHLYQHHPSLALPGLPPAVDVVELQLQQQH---Q 379

  Fly   322 DDANIPISNQEPSNSSIAANILKVLPSNCMVIKLPPNTKIFKTPGQAPAAPKD------SPTVTL 380
            ...::..:|...|:..:|                        |||........      |..|:.
  Fly   380 QQQHLQHNNSSSSSPKLA------------------------TPGDNSGNTSSYQQQYASQLVSG 420

  Fly   381 SG-------TENSTNF-------------IKIPKTISISTVGSMGNPHASAKTVQPTQTHSRSSC 425
            ||       :.||..:             |..|...:.:|..:...|.|.....|..|
  Fly   421 SGGGYLNGSSSNSYGYSWHSSQSFHTKYQIHPPSAAASATASATATPTAQLGAQQQQQ------- 478

  Fly   426 FLVDSFNNSKSRPESMKIINEFRNQIRSIEKTLP--LPGTVLQSSKVTMDESTSS--------PM 480
                                  :.|.:.:::..|  .|.|...||......|.||        |:
  Fly   479 ----------------------QQQQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPL 521

  Fly   481 DAP-----KPVELMLNPSALMVARELEIQYPLYRFMWTCPLCQRMFEKHCAFRAH---LTNKHDL 537
            ..|     .|...|:..:|...|:......|.|:                  :.|   |.|....
  Fly   522 TPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPPYQ------------------QGHVMGLINPPPT 568

  Fly   538 ----------TDEKCNVLKVVLMPSKILSQDSANAATQRVHVPLNPQTPVPPP------------ 580
                      ::..|......|.|:..:.|.......|:|     ||...||.
  Fly   569 LQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQV-----PQQQPPPTPRSSGGGRRGRH 628

  Fly   581 --ELPNT-VNLPLLLSKTSAPLTGQTSALSNVPVNKGLSPTSINIEKPKVSKKPKKNQSFQC--T 640
              ..|.| .::..|:|            :..|..|:..:|   .:||.::         ..|  .
  Fly   629 SHHQPGTAAHIASLMS------------VRTVRYNRRNNP---ELEKRRI---------HHCDFV 669

  Fly   641 ECLKVFTTFGALRIHKSIHTGELPYQCSY--CDKRFRTPGQVRVHHRRHTGEKPFKCKICSLDFT 703
            .|.||:|....|:.|:.|||||.||.|.:  |:.||....::..|:|:|||.|||||.:|...|.
  Fly   670 GCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFA 734

  Fly   704 HRETLISHLSRHI 716
            ..:.|..|:.||:
  Fly   735 RSDHLALHMKRHL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	4/9 (44%)
		C2H2 Zn finger	165..186	CDD:275371	4/20 (20%)
		C2H2 Zn finger	639..659	CDD:275368	7/21 (33%)
		zf-H2C2_2	651..676	CDD:290200	13/26 (50%)
		C2H2 Zn finger	667..687	CDD:275368	6/21 (29%)
		zf-H2C2_2	680..704	CDD:290200	12/23 (52%)
		C2H2 Zn finger	695..715	CDD:275368	5/19 (26%)
		C2H2 Zn finger	723..742	CDD:275368
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	31/106 (29%)
		C2H2 Zn finger	671..688	CDD:275368	6/16 (38%)
		zf-H2C2_2	680..707	CDD:290200	13/26 (50%)
		C2H2 Zn finger	696..718	CDD:275368	6/21 (29%)
		zf-H2C2_2	710..735	CDD:290200	12/24 (50%)
		C2H2 Zn finger	726..746	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BRQ6
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900