DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10462 and Wiz

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	XP_036016381.1	Gene:	Wiz / 22404	MGIID:	1332638	Length:	1871	Species:	Mus musculus

Alignment Length:	902	Identity:	180/902 - (19%)
Similarity:	302/902 - (33%)	Gaps:	283/902 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DTLKILDEGSQMI---TVPIRDRLRSEDERLFI-ASLELGHQQIFASESEDNPNPK-----HCDI 81
            :|:..:|.||.::   ::|:...|.....||.. .:.|:.|     ...::.|:.|     .|::
Mouse   905 NTMVAMDLGSPLLPKKSLPVSGTLEQVASRLSSKVAAEVPH-----GSKQELPDLKAQSLTTCEV 964

  Fly    82 CQYKFKSQQDISSHRVHHEMNLHFCRLG------CGIWLDTLEKILEHE-------------YRQ 127
            |...|::::.:|||     ...|..:||      .|..:|.|.::::.:             .::
Mouse   965 CGACFETRKGLSSH-----ARSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAPLGLTPSLTKK 1024

  Fly   128 HFQPGRVLCCRVCDFMANSAD----DLASHMQKHIYVYRFVCSICRRHFESKQSLNLHRKQSQDF 188
            ...|.        :|:|.:|.    .||..|                   ...::|...|....|
Mouse  1025 SNSPK--------EFLAGAARPGLLTLAKPM-------------------DAPAVNKAIKSPPGF 1062

  Fly   189 CSLLDFRKG----SSS----KPELVAVSTPV---PEESNCYVQIKEEPLNAEEADRMLLEDNPPL 242
            .:     ||    |||    |..|....:|.   ||:.:..:.:...| .:.:|.....||..||
Mouse  1063 SA-----KGLTHPSSSPLLKKAPLTLAGSPTPKNPEDKSPQLSLSPRP-TSPKAQWPQSEDEGPL 1121

  Fly   243 NVKLEPQDEEMPDVS-----------------------RIKEEQSNGSVWTAIHTPLRN---KLR 281
            |:.|:.......|..                       .:.:..:.||....:|..:|.   ::|
Mouse  1122 NLTLDSDGGRELDCQLCGAWFETRKGLSSHARAHLRHLGVSDPDAKGSPIDVLHGLIRRDGIQIR 1186

  Fly   282 LP----ALA---------TTKNQMHLKPGVKRNGLLTSNVESLNKKSNHSV-----ISDDANIPI 328
            ||    |||         |..:.:...|..|:..|..|.:.|...|.:.|.     .||....|:
Mouse  1187 LPPGRGALAQLGRPPSASTALSLLPPPPPAKKAKLKASGMASPWGKQDLSAAGIFWASDVEPSPL 1251

  Fly   329 ---SNQEPSN-----------------SSIAANILKVL-PSNCMVIKLPPNT--KIFK-----TP 365
               |..||:.                 ||.|.:.|:.: .:...|...|.:|  :|.|     .|
Mouse  1252 NLSSGPEPTRDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWYVNGSPIDTLREILKRRTQSRP 1316

  Fly   366 GQAPAAPKDSP----TVTLSGTENSTNFIKIPKTISISTVGSM-----GNPHASAKTVQPTQTHS 421
            |.....|..||    .|..:|...|:...:.|..:.||.:...     |:|...:.|..|..|..
Mouse  1317 GGHLHPPGPSPKALAKVLSTGGPGSSLEARSPSDLHISPLTKKLPPPPGSPLGHSPTASPPPTAR 1381

  Fly   422 RSSCFLVDSFNNSKSRPESMKIINEFRNQIRSIEKTLPLPGTVLQSSKVTMDESTSSPMDAPKPV 486
            :....|.......|.:||.|::  |.:.::        ||||:...     ...:..|...|:..
Mouse  1382 KMFSGLATPSLPKKLKPEHMRV--EIKREM--------LPGTLHGE-----PHPSEGPWGTPRED 1431

  Fly   487 ELMLNPSA-LMVARELEIQYPLYRFMWTCPLCQRMFEKHCAF----RAHLTNKHDLTDEKCN--- 543
            ...||.|| ....|::.           |..|...||.....    |:|| .:..:|:...|
Mouse  1432 MAPLNLSARAEPVRDIR-----------CEFCGEFFENRKGLSSHARSHL-RQMGVTEWSVNGSP 1484

  Fly   544 ---VLKVVLMPSKI---------------LSQD-SANAATQRVHVPLNPQTPVPPPELPNTVNLP 589
               :.:::...||:               |::| |..||...:|.||    |:.|
Mouse  1485 IDTLREILKKKSKLCLIKKEPPAGDLAPALTEDGSPTAAPGALHSPL----PLSP---------- 1535

  Fly   590 LLLSKTSAPLTGQTSA---LSNVPVNKGLSPTSINIEKPKVSKKPKKNQSFQCTECLKVFTTFGA 651
             |.|:...|..|.|..   ||..|:. |..|::.:...|..:|:|.:...|...|
Mouse  1536 -LASRPGKPGAGPTQVPRELSLSPIT-GSKPSAASYLGPVATKRPLQEDRFLPAE---------- 1588

  Fly   652 LRIHKSIHTGELPYQCSYCDKRFRTPGQVRVHHRRHTGEKPFKCKICSLDFTHRETLISHLSRHI 716
            ::....|.| |||::..            .:|.:.........|::|.|.|.:|:.|.||...|:
Mouse  1589 VKAKTYIQT-ELPFKAK------------TLHEKTSHSSTEACCELCGLYFENRKALASHARAHL 1640

  Fly   717 GMKRYKCYGCDKYFV---VVSGLRAHRRLRPDTCGKV------------KFTARAHG 758
                 :.:|..::.|   .:..|....:.||...|..            ||.:..||
Mouse  1641 -----RQFGVTEWCVNGSPIETLSEWIKHRPQKVGAYRSYIQGGRPFTKKFRSAGHG 1692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	6/23 (26%)
		C2H2 Zn finger	165..186	CDD:275371	2/20 (10%)
		C2H2 Zn finger	639..659	CDD:275368	1/19 (5%)
		zf-H2C2_2	651..676	CDD:290200	5/24 (21%)
		C2H2 Zn finger	667..687	CDD:275368	1/19 (5%)
		zf-H2C2_2	680..704	CDD:290200	5/23 (22%)
		C2H2 Zn finger	695..715	CDD:275368	8/19 (42%)
		C2H2 Zn finger	723..742	CDD:275368	3/21 (14%)
Wiz	XP_036016381.1	C2H2 Zn finger	310..330	CDD:275368
		C2H2 Zn finger	347..367	CDD:275368
		C2H2 Zn finger	396..416	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100