DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10462 and znf644b

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	XP_003198829.2	Gene:	znf644b / 100537559	ZFINID:	ZDB-GENE-120214-23	Length:	1267	Species:	Danio rerio

Alignment Length:	1036	Identity:	192/1036 - (18%)
Similarity:	304/1036 - (29%)	Gaps:	427/1036 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KMEPQDEVTDSSIRILSACD---TLKIL---------DEGSQMITVPI-----RDRLRSEDERLF 54
            :.||:.....:.:|:...||   .:|.|         |||...:....     ..||::|
Zfish   314 RKEPESLKAYAGLRLEKFCDKSAAMKELISSEKEERCDEGGSDVETNTYMGEKLARLKTE----- 373

  Fly    55 IASLELGHQQIFASESEDNPNPKHCDICQYKFKSQQDISSHRVHHEMNLHFCRLGCGIWLDTLEK 119
               .:.|.:..|..          |..|...||.::.:..|.::|              ||...|
Zfish   374 ---TKTGEELSFFP----------CSKCNETFKEKRHLHRHMMYH--------------LDRNNK 411

  Fly   120 ILEHEYRQHFQPGRVLCCRVCDFMANSADDLASHMQKHIYVY---------------------RF 163
            :     ||...| |...||.|   ..|..||.| :|||:.::                     |.
Zfish   412 V-----RQEHVP-RPFICREC---GRSFRDLTS-LQKHMIIHQVRRERLMEEIKGFSKIDVEGRR 466

  Fly   164 VCSICRR-HFESKQSLNLHR-----KQSQDFC--SLLDFRKGSSSKPELVAVSTPVPEESNCYV- 219
            .|..|.: .|.:|......|     ::.:.:|  ......|......|..|......:..:|:.
Zfish   467 ACLQCPQCVFGTKCPKTFIRCGKTNEKEKPYCFEDCHHMTKSEVEAHECTAHHNTCAKTEDCFAC 531

  Fly   220 ------------------QIKEEPLNAEEADRMLLEDNPPLNVKLEPQDEEMPDVSRIKEEQSNG 266
                              .|..:|...:      .|..|..||..:|:.:::
Zfish   532 QNCTFTSNNRFSFRKHVELIHRQPYYDD------YEPQPHSNVDDQPKTKDL------------- 577

  Fly   267 SVWTAIHTPLRNKLRLPALATT-------KNQMHLKPGVKRNGLLTSNVES-------------- 310
                        .|.:|.:.:|       :.::..:|    ||....||.|
Zfish   578 ------------SLPMPKIQSTEKWSVKDRGELPFRP----NGSADLNVRSEETQKACDGFSLSL 626

  Fly   311 --------LNKKSNHSVISDDAN------------------IPISNQEPSNSSIAANILKVLPSN 349
                    .||.|..|:.||..:                  :...||| ..|:::....|.|.|
Zfish   627 IKWSPGSPANKLSPFSLRSDKPSKLSPLPTEKIDVTTGLPYVEEDNQE-YESTVSEKRTKYLSS- 689

  Fly   350 CMVIKLPPNTKIFK-----TPG--QAPAAPKDSPTVTLSGTENSTNFIKIP--KTISISTVGSMG 405
             ....|...|:|..     .||  ..|..|..|.|:.|....:     |||  :.:||....:..
Zfish   690 -FDAHLTAKTEIVSKAACLNPGTESRPKDPSTSSTLALQTLRH-----KIPSKRKMSIPYRNTHA 748

  Fly   406 N-PHAS------------AKTVQP--------------------TQTHSRSSCFLVDSFNN---- 433
            : ||.|            :.|.|.                    .|:::.|..|:  .|||
Zfish   749 DIPHVSLPECESESPQWDSSTPQEGDDYEGAQDFSKCTKESPDWFQSNTPSDYFI--PFNNNIPD 811

  Fly   434 --SKSRPESMKIINEFRNQIRS-------IEKTLPLPGTVLQSSKVTMDESTSSPMDAPKPV-EL 488
              |.|.||..  |.|..::||:       ||.|:         |:...|||.....|   |. :.
Zfish   812 YASHSNPEDS--IEEDSDEIRTFIIKEECIESTI---------SEDNPDESVYQQSD---PYGQY 862

  Fly   489 MLNPSALMVARELEIQYPLYRFMWTCPLCQRMFEKHCAF----RAHLTN---KHDLTDEKCNVLK 546
            :::|.: :|.|:            .||.|..:||.....    |.||..   .:|        .:
Zfish   863 VVSPFS-VVGRK------------CCPYCPAVFESGVGLSNHVRGHLYRVGLSYD--------AR 906

  Fly   547 VVLMPSKILSQDSANAATQRVHVPLNPQTPVPPPELPNTVNLPLLL----SKT--SAPLTGQTSA 605
            .|:.|.::.|||......::: ..:|.:.....||.......||.|    :||  |..:.|....
Zfish   907 HVVSPEQVASQDRQPRIRRKI-PSVNRRIRKDKPESKTEHTCPLCLGWFDTKTGLSNHVRGHLKR 970

  Fly   606 LSNVPVNKGLSPTSI------------NI-----EKPKVSKKPKKNQSFQCTECLKVFTTFGALR 653
            :.........||.||            ||     .:|::| ||..::.|  ..|..:|.|...
Zfish   971 IGKPISGASKSPLSILSELLQDETEYKNIMRVFGSRPQLS-KPFVSRKF--ASCDGLFLTSSG-- 1030

  Fly   654 IHKSIHTG-------------------------------------------ELPYQ--------- 666
            |...||.|                                           |:..:
Zfish  1031 IPMKIHHGTSKPDEGHWTMIRPPQVDRERKKTDKVQSSTLEDLLGNREVEQEMEVEDHSEEASTP 1095

  Fly   667 ---CSYCDKRFRTP--------GQVRVHHRRHTGEKPFKCKICSLDFTHRETLISHL-----SRH 715
               .|.||...|||        .|.:....::|      |..|::.|....:|.:||     .:.
Zfish  1096 LTIYSTCDGIPRTPSVKLDPTWSQEKFAANKNT------CIHCNMTFHSGVSLSNHLRAYARRKK 1154

  Fly   716 IGMKRYKCYGCDKYFVVVSGLRAHRRLRPDTCGKVKFTARAHGPRVRVIR-----GEVVFQ 771
            |.::....|.|.         :...|.||             ||:.:|..     .||:::
Zfish  1155 IAIEEGTTYDCK---------QKRPRSRP-------------GPKRKVFSSSHAVSEVIYR 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	8/19 (42%)
		C2H2 Zn finger	165..186	CDD:275371	5/26 (19%)
		C2H2 Zn finger	639..659	CDD:275368	4/19 (21%)
		zf-H2C2_2	651..676	CDD:290200	8/79 (10%)
		C2H2 Zn finger	667..687	CDD:275368	7/27 (26%)
		zf-H2C2_2	680..704	CDD:290200	4/23 (17%)
		C2H2 Zn finger	695..715	CDD:275368	6/24 (25%)
		C2H2 Zn finger	723..742	CDD:275368	2/18 (11%)
znf644b	XP_003198829.2	C2H2 Zn finger	385..405	CDD:275370	5/19 (26%)
		zf-C2H2	421..443	CDD:306579	10/25 (40%)
		C2H2 Zn finger	423..443	CDD:275370	10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100