DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10462 and znf236

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	XP_012820832.1	Gene:	znf236 / 100144676	XenbaseID:	XB-GENE-996915	Length:	1925	Species:	Xenopus tropicalis

Alignment Length:	900	Identity:	166/900 - (18%)
Similarity:	271/900 - (30%)	Gaps:	345/900 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ASESEDNPNPKHCDICQYKFKSQQDISSHRVHHEMNLHFCRLGCGIWLDTLEKILEH--EYRQHF 129
            |:.:.|:|.   |..|:.||.....:.:|.:.||.........||........:..|  |:||..
Frog    84 ATHNVDDPT---CPACRKKFSRVASLKAHIMLHEKEETLICSECGDEFTLPNNLSLHMEEHRQEL 145

  Fly   130 QPGRVLCCRVCDFMANSADDLASHMQKHIYV----------------YRFVCSICRRHFESKQSL 178
            ...:...|:.|....:|...|..||:.|..:                :.:.|..|.:.|:....|
Frog   146 VGSKTYSCKSCKKTFDSTPQLKEHMKTHFKIRVANTRSYNRNIDRSGFSYSCPHCGKTFQKPSQL 210

  Fly   179 NLH-------RKQSQDFCSLLDFRKGSSSKPELVAVSTPVPEESNCYVQIKEEP-----LNAEEA 231
            ..|       |....:.|.....:||        |::|.:.:.:.      |:|     ..|..:
Frog   211 TRHIRIHTGERPFKCNICGKAFNQKG--------ALATHMVKHTG------EKPHACAFCPAAFS 261

  Fly   232 DRMLLEDNPPLNVKLEPQDEEMPDVSRIKEEQSNGSVWTAIHTPLRNKLRLPALATTKNQMHL-- 294
            .:..|:.:                :.|:..|..||:.:.........| .|.:|.|..::||:
Frog   262 QKGNLQSH----------------IQRVHSEVKNGATYHCTDCSCIFK-SLGSLNTHISKMHVVG 309

  Fly   295 -------KPGVKRNGLLTSNVESLNKKSNHSVISDD--ANIPISNQEPSNSSIAANILKVLPSNC 350
                   ..|.......||..:||:..|.....|||  .|:.:....|:.:.
Frog   310 SQTTPAPTGGTSTVTTDTSQPQSLSDSSLLQQTSDDKWKNVTVFQAVPAQTD------------- 361

  Fly   351 MVIKLPPNTKIFKTPGQAPAAPKDSPTVTLSGTENSTNFIKIPKTISISTVGSMGNPHASAKTVQ 415
                   :|....:..|.|    ..|.||          ..|.:.:.:|               :
Frog   362 -------STDCSASEQQGP----QQPAVT----------DVIQQLLELS---------------E 390

  Fly   416 PTQTHSRSSCFLVDSFNNSKSRPE---SMKIINEFRNQIRSIEKTLPLPGTVLQS----SKVTMD 473
            |           ||:..||:|..:   |:.|..:...|.........:|...|.|    :|.|:.
Frog   391 P-----------VDNPQNSQSEQQLNISVGINRDILQQALENSGLSSIPVAALPSDTSQAKATVQ 444

  Fly   474 E---STSSPMD---------------APKPVELMLNP----SALMVARELEIQYPLYRFMWTCPL 516
            |   .::..||               |.|..:.::..    ||..|..|..|::.:      |..
Frog   445 EIECLSTQQMDCNDQEHEVEHEEQDKADKTEKRIIKKKSAFSAGSVREESGIRWHI------CTY 503

  Fly   517 CQRMFEKHCAFRAHLTNKHDLTDEKCNVLKVVLMPSKILSQDSANAATQRVHVPLNPQTPVPPPE 581
            |.:.|:|......|:                                  |:|
Frog   504 CNKEFKKPSDLVRHI----------------------------------RIH------------- 521

  Fly   582 LPNTVNLPLLLSKTSAPLTGQTSALSNVPVNKGLSPTSINIEKPKVSKKPKKNQSFQCTECLKVF 646
               |...|....:.......:::..:::..:.|:                   ::|:|..|:|.|
Frog   522 ---THEKPFKCLQCFRAFAVKSTLTAHIKTHSGI-------------------KAFKCDFCMKCF 564

  Fly   647 TTFGALRIHKSIHTGELPYQCSYCDKRFRT-------------------------PGQVRV---- 682
            :|.|:|::|..:|||..|:.|.:|||:|||                         ||:|||
Frog   565 STSGSLKVHIRLHTGVRPFACPHCDKKFRTSGHRKTHIASHFKQCELRKLRQQRKPGKVRVGKSN 629

  Fly   683 ---------------------------------------------------------------HH 684
                                                                           |.
Frog   630 VPVSEIPLQEPILITDLGLIQPIPRNSQFFQNYFINSYTHEVDRPYKCYYCHRAYKKSCHLKQHI 694

  Fly   685 RRHTGEKPFKCKICSLDFTHRETLISHLSRHIGMKRYKCYGCDKYFVVVSGLR----AHRRLRPD 745
            |.|||||||||..|...|.....|.:|:..|.|::.|||..|:..|.....||    .|..|||.
Frog   695 RSHTGEKPFKCTQCGRGFASSGVLKAHIRTHTGLRDYKCLVCNGAFTTGGSLRRHMCIHNDLRPY 759

  Fly   746 TCG------KVKFTARAHGPRVRVIRGEVVFQYHPEHNGYLRSEDPLNILSQRDQ 794
            .|.      |.....:.|   ::..|.||..|.| :|...:..|.|.:.:...:|
Frog   760 MCPYCQKTFKTSLNCKKH---MKTHRYEVASQLH-QHQPAVSEETPADQIHVSNQ 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	6/19 (32%)
		C2H2 Zn finger	165..186	CDD:275371	6/27 (22%)
		C2H2 Zn finger	639..659	CDD:275368	8/19 (42%)
		zf-H2C2_2	651..676	CDD:290200	11/24 (46%)
		C2H2 Zn finger	667..687	CDD:275368	14/111 (13%)
		zf-H2C2_2	680..704	CDD:290200	16/90 (18%)
		C2H2 Zn finger	695..715	CDD:275368	5/19 (26%)
		C2H2 Zn finger	723..742	CDD:275368	6/22 (27%)
znf236	XP_012820832.1	COG5048	<25..230	CDD:227381	30/148 (20%)
		C2H2 Zn finger	37..57	CDD:275368
		C2H2 Zn finger	66..86	CDD:275368	1/1 (100%)
		C2H2 Zn finger	93..113	CDD:275368	5/19 (26%)
		C2H2 Zn finger	121..141	CDD:275370	3/19 (16%)
		C2H2 Zn finger	153..173	CDD:275368	6/19 (32%)
		zf-C2H2	195..217	CDD:333835	5/21 (24%)
		C2H2 Zn finger	197..217	CDD:275368	5/19 (26%)
		COG5048	221..>560	CDD:227381	75/504 (15%)
		C2H2 Zn finger	225..245	CDD:275368	5/27 (19%)
		C2H2 Zn finger	253..274	CDD:275368	3/36 (8%)
		C2H2 Zn finger	285..306	CDD:275368	4/21 (19%)
		C2H2 Zn finger	501..521	CDD:275368	6/53 (11%)
		C2H2 Zn finger	529..549	CDD:275368	0/19 (0%)
		C2H2 Zn finger	557..577	CDD:275368	8/19 (42%)
		zf-H2C2_2	569..594	CDD:372612	11/24 (46%)
		C2H2 Zn finger	585..605	CDD:275370	7/19 (37%)
		COG5048	672..1089	CDD:227381	39/142 (27%)
		C2H2 Zn finger	677..697	CDD:275368	2/19 (11%)
		C2H2 Zn finger	705..725	CDD:275368	5/19 (26%)
		C2H2 Zn finger	733..753	CDD:275368	5/19 (26%)
		C2H2 Zn finger	761..781	CDD:275368	3/22 (14%)
		COG5048	981..>1292	CDD:227381
		C2H2 Zn finger	983..1003	CDD:275368
		C2H2 Zn finger	1011..1031	CDD:275368
		C2H2 Zn finger	1039..1059	CDD:275368
		C2H2 Zn finger	1186..1206	CDD:275368
		C2H2 Zn finger	1214..1234	CDD:275368
		C2H2 Zn finger	1242..1262	CDD:275368
		C2H2 Zn finger	1270..1290	CDD:275370
		C2H2 Zn finger	1735..1756	CDD:275368
		zf-C2H2	1762..1784	CDD:333835
		C2H2 Zn finger	1764..1784	CDD:275368
		C2H2 Zn finger	1800..1820	CDD:275368
		zf-H2C2_2	1813..1837	CDD:372612
		C2H2 Zn finger	1828..1848	CDD:275368
		zf-H2C2_2	1840..1865	CDD:372612
		C2H2 Zn finger	1856..1877	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100