DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10462 and znf644a

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	NP_001265183.1	Gene:	znf644a / 100007441	ZFINID:	ZDB-GENE-030131-6244	Length:	1169	Species:	Danio rerio

Alignment Length:	879	Identity:	176/879 - (20%)
Similarity:	289/879 - (32%)	Gaps:	257/879 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IRDRLRSEDE--RLF-----IASLELGHQQIFASESEDNPNP---KHCDICQYKFKS-QQDISSH 95
            ||:.|.|:.|  ..|     .....||..||..::...:..|   |.|..|.|...| ...||.|
Zfish   305 IRETLSSDSEGPTFFQQNNDFKEKSLGQNQITCNKDTTSSKPFVCKECGQCYYDRSSLLNHISVH 369

  Fly    96 RVHHEMNLHFCRL------------GCGIWLDTLEKILEHEYRQHFQPGRVLCCRVCDFMANSAD 148
            :...:....|.::            .|....:.....::|. :.|.:..|...|..|||:..:.|
Zfish   370 QDKGKKLNQFHQIKDEGKDAKLQCPQCNFGTNCPNTFVQHA-KTHEKDKRYYSCNKCDFVEMNED 433

  Fly   149 DLASHMQKHIYVYRFVCSICRRHFESKQSLNLHRKQSQDFCSLLDFRKGSSSKPELVAVSTPVPE 213
            ||    ::|:|....|  |...|...|......||.::..|  |:....|..:....:|...|.|
Zfish   434 DL----RRHLYHKHGV--IGADHTVWKSDGFQERKVNKSPC--LNSYSPSFERKTKNSVGNHVEE 490

  Fly   214 E---SNCYVQIKEEPLNAEE---ADRMLLE------DNPPLNVKLEPQDEE------MPDVSRIK 260
            |   |:......|||...|:   |..:|..      .:|.|.||....|||      ...:.|.|
Zfish   491 EQVNSHSLDSGDEEPPTTEQSFSACNVLTSCAKPKARSPRLLVKFGAPDEENNLSNDKCGLLRKK 555

  Fly   261 EEQSNGSVWTAIHTPLRNKLRL------------PALATTKNQMHLKPGVKRNGLLTSNVES-LN 312
            :......:..:|||.|..|.|.            ||.::||..:......:.....||:..| ..
Zfish   556 KRVGESKLDKSIHTLLSRKKRRDKSGSEIDTHQEPAKSSTKEFLDRSLNCETTFSETSSPPSKYL 620

  Fly   313 KKSNHSVISD-------DANIPISNQE-PSNSSIAANILKVLPS-------------NCMVIKLP 356
            |:|.||...:       |.|:..|... .::..:....||..||             ..:::..|
Zfish   621 KRSAHSKEGNTKRTSKFDVNVTCSEDAGKTHLGLEKQTLKKSPSKRKMSTPFHNMQGQDILLDFP 685

  Fly   357 PNTKIFKTPGQAPAAPKDSPTVTLSGTENSTNFIKIPKTISISTVGSMG------NPHASAKTVQ 415
            ...:.||.|               ..|......|.....:|:|: .::|      :.:|:|:.|:
Zfish   686 KCRQKFKKP---------------QATRRRKVLINNSDILSVSS-DALGPEECEMDKNANARLVK 734

  Fly   416 PTQTHSRSSCFLVDS-FNNSKSRPESMKIINEFRNQ-----IRSIE-----------KTLPLPGT 463
            ...:.|::|.....| |..:.|.|..:.:.:|::::     |.:::           |..|....
Zfish   735 RRSSSSKASLGASASHFERNHSSPRVLSVKDEYKDEEISESITAVKLEPSSDVETDLKGCPYCPA 799

  Fly   464 VLQS-------------------------------------------SKVTMDESTSSPMDAPKP 485
            |.:|                                           |:|..:|.||   ....|
Zfish   800 VFESGISLSNHIRGHLHRVGLKVRRAPVKSAVKVASDKVPPVRRQALSQVKTEEDTS---QTDHP 861

  Fly   486 VELMLNPSALMVARELEIQYPLYRFMWTCPLCQRMFEKHCAF----RAHLTN------------- 533
            .||..:      .::.|:         .||||:..|:.....    |.||..
Zfish   862 AELPTD------CQQTEL---------ICPLCREWFDNRTGLSNHVRGHLKRLGKPTSTASKSPV 911

  Fly   534 ---KHDLTDEKCNVLKVVLMPSKILSQDS------ANAAT-------------QRVHVPLNPQTP 576
               |..:.|:|...||:.::..|..:.::      .|..|             ::..:.:|..:
Zfish   912 IILKELMRDKKQFQLKLQVLEKKCRTTNTFYPVRLGNGLTFASTVKRQKDDKEEKKRLEINKGS- 975

  Fly   577 VPPPELPNTVNLPLLLSKTSAPLTGQTSALSNVPVNKGLSPTS-------INIEKPKVSKKPKK- 633
             ||.:|..      :|.|..|....:....| :...|.||.||       |:..|...|...:|
Zfish   976 -PPSDLIG------ILKKRRAHEEAKAKHQS-LTAKKALSLTSGKDCGLEIHTCKAVPSSPGEKG 1032

  Fly   634 -NQSFQCTECLKVFTTFGALRIH---------KSIHTGELPYQCSYCDKRFRTPGQVRVHHRRHT 688
             |:...|..|...|.:..:|..|         |::..| ....|....:|.|...:.:.....|.
Zfish  1033 DNKRNVCVHCNASFHSGISLSNHLRGYSQRKRKALQDG-ATLDCKQRKQRARPWSKKKAFSLMHN 1096

  Fly   689 GEKPFK--CKICSLDF----THRETLISHLSRHI 716
            .|:.::  |:.|.|.|    :.:|..|.||.|||
Zfish  1097 PEEIYRLTCRFCDLVFQGPLSVQEDWIKHLQRHI 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	7/19 (37%)
		C2H2 Zn finger	165..186	CDD:275371	5/20 (25%)
		C2H2 Zn finger	639..659	CDD:275368	6/28 (21%)
		zf-H2C2_2	651..676	CDD:290200	6/33 (18%)
		C2H2 Zn finger	667..687	CDD:275368	3/19 (16%)
		zf-H2C2_2	680..704	CDD:290200	6/29 (21%)
		C2H2 Zn finger	695..715	CDD:275368	8/23 (35%)
		C2H2 Zn finger	723..742	CDD:275368
znf644a	NP_001265183.1	C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	393..413	CDD:275368	2/20 (10%)
		C2H2 Zn finger	422..439	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100