DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10462 and wizb

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	XP_009297507.1	Gene:	wizb / 100001879	ZFINID:	ZDB-GENE-131126-2	Length:	1997	Species:	Danio rerio

Alignment Length:	893	Identity:	174/893 - (19%)
Similarity:	297/893 - (33%)	Gaps:	299/893 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EDERLFIASLELGHQQIFASESEDNPN-----------PKHCDICQYKFKSQQDISSHRVHHEMN 102
            ||:...::.|      |.|...||:.:           .:.|..|..:|.:...:::|     :.
Zfish   735 EDDEDVVSRL------IGALTEEDDDDDDDRDGLLKSVERKCPYCPDRFHNGIGLANH-----IR 788

  Fly   103 LHFCRLGCGI---------WLDTLEKILEHEYRQ----HFQPG--RVLCCRVCDFMANSADDLAS 152
            .|..|:|...         .::.:||...::.::    :|.|.  .|:.|..|....::...|:|
Zfish   789 GHLNRVGVSYNVRHFISPEEVNAIEKKFSYQKKKKKVANFDPSTFSVMRCEFCSAGFDTRAGLSS 853

  Fly   153 HMQKHIYVYRFV--------CSICRRHFESKQSLNL-----HRKQS---QDFCSLLDFRKGSSSK 201
            |.:.|:..:...        .:|.|:.|....:|.|     |..||   |:.....:.||....:
Zfish   854 HARAHLRDFGITNWEVTVSPINILRQLFAKHPNLVLPTASTHTLQSSPEQNSDEEQESRKDMKDE 918

  Fly   202 PELVAVSTPVPEE------SNCYVQIKE--EPLNAEEADRMLLEDNP-----PLNVKLEPQ---- 249
            .::    |..|:.      ..|:.:..:  ||...|.|:....||:.     ||..||...
Zfish   919 DDM----TAEPDTFSSVFLKQCWKEEHDISEPEGGEGAEDDEEEDDDDETQMPLTDKLSTSPGHK 979

  Fly   250 -----DEEMPDVSRIKEEQSN-------GSVW---TAIHTPLRNKLRLPALATTKNQMH----LK 295
                 |||.|:........||       |:.:   ..:.|..|:.||.|.:..::|...    |.
Zfish   980 TLFSLDEESPESKDTDPRGSNLLKCSVCGATFETRRGLSTHSRSHLRQPGMGMSENSRAPIDLLY 1044

  Fly   296 PGVKRNGLLTSNVESLNKKSNH-------SVISD--------DANIPIS------NQEPSNSSIA 339
            ...|.:   :.:.:|..|:..|       |.:.|        |...|:.      :..|:..|.|
Zfish  1045 QATKHH---SRDAQSPTKRKQHVPVVPVPSPMKDIETEEGLSDTKPPVMFSAIKVSPSPTTPSTA 1106

  Fly   340 ANILKVLPSNCMVIKLPPNTKIFKTPGQA---PAAPKDSPTVTLSGTENSTNFIKIP-------- 393
            .:    |||:..|....|:..:.|.|..:   .::|..|....:.|...|||    |
Zfish  1107 GS----LPSSPFVKSRSPSPVLRKAPISSLLPVSSPLRSQEHKILGKSQSTN----PSGPTKPFW 1163

  Fly   394 -----------------KTISISTVGSMGNPHASAKTVQPTQTHSRSSC--FLVDSFNNSKSRPE 439
                             |.|.....|      |..:|.:...:|:|:..  |.:: ::.||..|
Zfish  1164 APQDTDAPLNLTMDMDSKDIICQLCG------AWFETRKGLSSHARAHLRHFGIE-YSESKGSP- 1220

  Fly   440 SMKIINEF---------------------RNQIRSIEKTL--------PLPG------TVLQSSK 469
             :.::|.|                     |:|..||...|        |||.      |.....|
Zfish  1221 -IDLLNRFILTDDFKHRANSFLSDGPEDLRSQKTSITSLLPSTSSSKRPLPSSPVLYKTAASPLK 1284

  Fly   470 VTM-DESTSSPMDAPKPVELMLNPSALMVARELE---IQYPLYRFM-WTCPLCQRMFEKHCAF-- 527
            .|: .::|||......|.:..|.||||.|.|..:   :.:|:.... .:|..|..:||.....
Zfish  1285 TTIGSKATSSTHTLLGPPKKKLKPSALQVLRFSDGEMMSFPIEPLKDVSCEFCGELFENRKGLSS 1349

  Fly   528 --RAHLTNKHDLTDEKCN-----VLKVV--------LMPSKILSQDSANAATQRVHVPLNPQTP- 576
              |:|| .:..:|:...|     .||.:        :||.|                  :|::|
Zfish  1350 HARSHL-RQLGITEWSVNGSPIDTLKEIIVRRGLPTIMPLK------------------SPKSPS 1395

  Fly   577 VPPPELPNTV------------NLPLLLSKT----------SAPLTGQTSALSNVPVNKGLSPTS 619
            .|.|.||..:            .||...:||          .:|.|..||           ||..
Zfish  1396 SPSPGLPRHMLQSSSPSGNIIGRLPFHFAKTPNHDQPAIHKMSPSTSTTS-----------SPPI 1449

  Fly   620 INIEKPK----VSKKPKKNQSFQCTECLKVFTTFGALRIHKSIHTGELPYQCSYCDKRFRTPGQV 680
            :::.|||    :.:...|.......|      .:....:|.|:.:.:..|..:....:.:.|
Zfish  1450 VDLVKPKPEPEIVEVTMKGSDMGADE------HYSPEPLHSSLISSDNVYPVNLVMTQEKEP--- 1505

  Fly   681 RVHHRRHTGEKPFKCKICSLDFTHRETLISHLS---RHIGMKRYKCYG 725
                     .:..:|:.|...|.:|:.|.||..   ||:|:..:...|
Zfish  1506 ---------SRDIRCEFCGEFFENRKGLSSHARSHLRHMGITEWSVNG 1544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	5/19 (26%)
		C2H2 Zn finger	165..186	CDD:275371	8/28 (29%)
		C2H2 Zn finger	639..659	CDD:275368	3/19 (16%)
		zf-H2C2_2	651..676	CDD:290200	3/24 (13%)
		C2H2 Zn finger	667..687	CDD:275368	1/19 (5%)
		zf-H2C2_2	680..704	CDD:290200	3/23 (13%)
		C2H2 Zn finger	695..715	CDD:275368	7/22 (32%)
		C2H2 Zn finger	723..742	CDD:275368	1/3 (33%)
wizb	XP_009297507.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100