DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and OSMR

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001310435.1 Gene:OSMR / 9180 HGNCID:8507 Length:980 Species:Homo sapiens


Alignment Length:756 Identity:157/756 - (20%)
Similarity:256/756 - (33%) Gaps:208/756 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 TPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRV 232
            |.|:.|:.|          ||....:.|:.:...|.:...||      .|...:..:|....:..
Human    76 TSNVIWVGN----------YSTTVKWNQVLHWSWESELPLEC------ATHFVRIKSLVDDAKFP 124

  Fly   233 PPTF----------SRPPETISEVML----------GSNL-----------NLSCIAVGSPMPHV 266
            .|.|          |....|..:::.          |:|:           |:||...|      
Human   125 EPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEG------ 183

  Fly   267 KWMKGSEDLTPE------NEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVV--KVQSLPT 323
            |.:.| |.|.|.      |.:|..||  :..||...|:...::....|.:..||.|  :.:....
Human   184 KQIHG-EQLDPHVTAFNLNSVPFIRN--KGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSC 245

  Fly   324 APTDVQISEVT---ATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISG---IIT----MYYV 378
            ...|.:....|   .|...|.||             .:|..:...|...||   :.|    ..:.
Human   246 ETEDFKTLHCTWDPGTDTALGWS-------------KQPSQSYTLFESFSGEKKLCTHKNWCNWQ 297

  Fly   379 VRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWE 443
            :...|..| |.|.:||.|.:.:...:.....|...:...       |.:|....::::..::|| 
Human   298 ITQDSQET-YNFTLIAENYLRKRSVNILFNLTHRVYLMN-------PFSVNFENVNATNAIMTW- 353

  Fly   444 PPETPNGQVTGYKVYYTTNS----NQPEASWNSQMVDNSELTT-------VSELTPHAIYTVRV- 496
                        ||:...|:    .|.|.....:|:....::.       :|||.|...|..|| 
Human   354 ------------KVHSIRNNFTYLCQIELHGEGKMMQQYNVSIKVNGEYFLSELEPATEYMARVR 406

  Fly   497 ---------------QAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKP--- 543
                           |.:|::.|.|...|   ...:.|..:|.|.        .|||.| ||   
Human   407 CADASHFWKWSEWSGQNFTTLEAAPSEAP---DVWRIVSLEPGNH--------TVTLFW-KPLSK 459

  Fly   544 THSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDT-------LYYIWLAARSQRGEGA 601
            .|::..|    |::|....|.   .:.|:||.:::......|       .|.|.:.|.:..|.. 
Human   460 LHANGKI----LFYNVVVENL---DKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGAS- 516

  Fly   602 TTPPIPVRTKQYGAPPRNITA----IATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGRE--- 659
                 |.......|.|.|...    ||.:....||||.|.|     |.:|.|.|.:.:..::   
Human   517 -----PASVIVISADPENKEVEEERIAGTEGGFSLSWKPQP-----GDVIGYVVDWCDHTQDVLG 571

  Fly   660 DDEATTMTLNMTSIVL--DELKRWTEY--KIWVLAGTSVGDGPRSHPIILR-----TQEDVPGDP 715
            |.:...:..|.||.|:  |..:....|  :|:.|:...:.       .:|.     :||..|.|.
Human   572 DFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIA-------CLLEKKTGYSQELAPSDN 629

  Fly   716 QDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDE-----GKGFLNE-----PFKFDV 770
            ..|....|.|.|..:|||....:.:.|.|:|||::.:....:     .|..|::     .:|.|.
Human   630 PHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDN 694

  Fly   771 VDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTP 811
            .:.....|..|:|::.|...:...|..|:|..:....|.||
Human   695 PEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTP 735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653 12/58 (21%)
Ig 159..228 CDD:299845 12/59 (20%)
I-set 234..318 CDD:254352 26/122 (21%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 22/86 (26%)
fn3 324..404 CDD:278470 18/89 (20%)
FN3 423..514 CDD:238020 22/117 (19%)
FN3 520..610 CDD:238020 22/99 (22%)
FN3 616..707 CDD:238020 24/106 (23%)
FN3 712..810 CDD:238020 26/107 (24%)
FN3 832..907 CDD:238020
FN3 914..1005 CDD:238020
FN3 1012..1101 CDD:238020
fn3 1106..1198 CDD:278470
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
OSMRNP_001310435.1 FN3 233..>288 CDD:304408 13/67 (19%)
FN3 335..407 CDD:214495 17/91 (19%)
WSXWS motif 416..420 0/3 (0%)
FN3 446..522 CDD:238020 21/97 (22%)
fn3 540..608 CDD:278470 19/72 (26%)
FN3 626..734 CDD:238020 26/107 (24%)
Box 1 motif 771..779
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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