Protein Alignment Lar and PTP1

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_010051.1
• Gene: PTP1 / 851368
• SGDID: S000002389
• Length: 335
• Species: Saccharomyces cerevisiae
• Alignment Length: 298
• Identity: 93/298 - (31%)
• Similarity: 140/298 - (46%)
• Gaps: 75/298 - (25%)

  Fly  1787 PCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFI----------DGYRYRSAYIAAQGPV 1841
            |.|..:||.|:|:|||.:||:|..   :.|:||:|||::          .||     |||.|||.
Yeast    50 PRNDARNRYVNIMPYERNRVHLKT---LSGNDYINASYVKVNVPGQSIEPGY-----YIATQGPT 106

  Fly  1842 QDAAEDFWRMLWEHN----STIVVMLTKLKEMGREKCFQYWPH---------------------- 1880
            :...:.||:|.: ||    :.::||:|.|.|..||||:||||.
Yeast   107 RKTWDQFWQMCY-HNCPLDNIVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDM 170

  Fly  1881 ---ERSVRYQYYVVDPIAEYNMPQYKLREFKV--TDARDGSSRTVRQFQFIDWPEQGVPKSGEGF 1940
               ...::.::..|..:.:|    |.:.:.|:  ||...|..:||..|.|..|.:...|:.....
Yeast   171 TQFPSDLKIEFVNVHKVKDY----YTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPI 231

  Fly  1941 IDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLS-IVLERMQYEGVLD------------- 1991
            ::.....|...   .:..||.|||||||||:|.||.|. ::.:.:.::.:.:
Yeast   232 MELCAHSHSLN---SRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRHSDRATEEYT 293

  Fly  1992 ---VFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026
               :.|.|..|||||..||||:||:.|.|.|| :||.|
Yeast   294 RDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAA-KYLNS 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401
		R-PTP-LAR-2	1784..2021	CDD:350402	89/291 (31%)
PTP1	NP_010051.1	PTP_fungal	79..323	CDD:350509	73/256 (29%)