DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Lifr

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_112310.1 Gene:Lifr / 81680 RGDID:621431 Length:1093 Species:Rattus norvegicus


Alignment Length:1404 Identity:260/1404 - (18%)
Similarity:459/1404 - (32%) Gaps:497/1404 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 QMTAARP--IAALSLLVLSL------------------------LTWTHP------TIVDAA--H 34
            :||.:.|  ::||:||.|.:                        .:|..|      |:.|..  .
  Rat    20 RMTPSLPWLLSALTLLHLMMHVNGLKRGVQQDLKCTTNNMRVWDCSWPAPLGVSPGTVKDICIKD 84

  Fly    35 PPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEP 99
            .|....:.:...|::..::.      ||...:|.::      :|.||::|:.|:  .:|::    
  Rat    85 RPHSCHRLETTNVKIPALSP------GDHEVTINYQ------NGFQSKFTLNEK--DVSLV---- 131

  Fly   100 VRAGRDDAPYECVAENGVGDAVSAD---ATLTIYEGDKTPA-GFP-------VITQGPGTR-VIE 152
                 .|.| |.:       ::|||   :||.:...||..| .:|       .:.|.|.|. |..
  Rat   132 -----PDTP-EIL-------SLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVAL 183

  Fly   153 VGHTVLMTCKAIGNPTPNIYWIKNQT--------------KVDMSNPRYSLKDGFLQIENSREED 203
            |....:::.|..|:     :|  |.|              :..:..||:|   |:        ::
  Rat   184 VSLNTVLSGKDKGH-----HW--NWTSELPLQCATHSVSIRWHIDYPRFS---GY--------KE 230

  Fly   204 QGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIA--------VG 260
            ..::..: :|...|.::: ||::            |.:.:  |:.|||:.:.||:        :|
  Rat   231 WSEWSPL-KNISWTRNTE-TNVF------------PQDKV--VLAGSNMTICCISTTKVLSGQIG 279

  Fly   261 S---PMPHVKWMKGSEDLTPENEMPIGRNV-LQLINIQESANY-TCIAASTLGQIDSV--SVVKV 318
            :   |:.|:                .|..| :.::||..|.|. :.:..||   :|.|  :||..
  Rat   280 NTFRPLIHL----------------YGETVAINILNIPVSENSGSNVIFST---VDDVYGTVVFA 325

  Fly   319 QSLPTAPTDVQISEVTATSVRLEWS------YKGPEDLQYYVIQ-YKPKNA-NQAFSEISGIITM 375
            ...|..|..:.........:...|:      ..||.:.:|.:.: ...|:| ...|.|::.  ..
  Rat   326 GYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRFEELAN--ET 388

  Fly   376 YYVVRALSPYTE-YEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMES--APRNVQVRTLSSST 437
            |::...::|..| :.|.:.|.|.:|:         |........|:..:  .|.:::|:.::|:.
  Rat   389 YWLTLKMAPDQEIHNFTLTARNPLGQ---------TESAIVINATERVALHVPISLKVKDVNSTV 444

  Fly   438 MVITWEPPETPNGQVTGYKV---YYTTNSNQPEASWNSQM---VDNSELTTVSELTPHAIYTVRV 496
            :.::|..|    |..|...:   .....:|..:...|..|   .|::....|.:|.|:.|||.||
  Rat   445 VTLSWYLP----GNFTKINLVCQIEICKANSKKEVRNVTMRGAEDSTYHVAVDKLNPYTIYTFRV 505

  Fly   497 QAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTY 561
            :.                                               |||.      :|.  :
  Rat   506 RC-----------------------------------------------SSET------FWK--W 515

  Fly   562 ANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATS 626
            :..::.||...:||....|  |||    |                    :::.:..:|:.     
  Rat   516 SKWSNEKRYLTTEATPSKG--PDT----W--------------------REWSSDGKNLI----- 549

  Fly   627 STTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLD-----ELK-RWTEYK 685
                 :.|.|.|:..:||:|:.|     .|.....|.|    ...|.:||     |:| ...:|.
  Rat   550 -----IYWKPLPINEANGKILSY-----NVSCSSSEET----QSLSEILDPQHKAEIKVNKNDYI 600

  Fly   686 IWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIH 750
            |.|:|..|.|..|   |..:.:.| :|.|...|:........|.:||:                 
  Rat   601 ISVVARNSAGSSP---PSKIASME-IPNDDITVEQAVGIGNRIFLSWQ----------------- 644

  Fly   751 AQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVP 815
                        :.|           |:|                        ...|:|......
  Rat   645 ------------HNP-----------NMT------------------------CDYVIKWCNSSW 662

  Fly   816 VRPTVSLKIMEREPIVSIELEWER-PAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNL 879
            ..|.:              |:|.: |:.:.|                          |....|..
  Rat   663 SEPCL--------------LDWIKVPSNSTG--------------------------TVIESDQF 687

  Fly   880 ERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGI 944
            :.||.|.|.:.|..:.|.......|....|..|...| |.|:...:.|.:.|.||....|...|.
  Rat   688 QPGVRYNFYLYGCTNQGYQLLRSTIGYIEELAPIVAP-NFTVEDTSADSILVKWDDIPVEELRGF 751

  Fly   945 ITRYDVQFHK-----------KIDHGLGSERNM------TLRKAVFTNLEENTEYIFRVRAYTKQ 992
            :..|...|.|           :..|.....:|:      |||.|   :|:..|.|...:||||..
  Rat   752 LRGYLFYFQKGERDTPKTRSLETSHSDIKLKNITDISQKTLRIA---DLQGKTSYHLVLRAYTHG 813

  Fly   993 GAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDW 1057
            |.||.....:|..|..:|.....|...|.:     :....|||   :|.|:          ..:|
  Rat   814 GLGPEKSMFVVTKENSVGLIIAILIPVAVA-----VIVGVVTS---ILCYR----------KREW 860

  Fly  1058 QTKTVGLTESADLVNLE--KFAQYAVAIAARFKNGLGRL--------------SEKVTVRIKPED 1106
            ..:|.    ..|:.|.|  |..|:..:: ....|.|..|              |..:..:|:..:
  Rat   861 IKETF----YPDIPNPENCKALQFQKSV-CEGSNALKTLEMNPCTPNHVEVLESRSIPPKIEDTE 920

  Fly  1107 V--PLNLRAHDVS----THSMTLSWSPPI---RLT-PVNYKISFDAMKVFVDSQGFSQTQIVPKR 1161
            :  |::.|..:.|    .:...:|:.|||   .:| |...:....:..|::|.|...|.|...:.
  Rat   921 ITSPVSERPGESSETDPENQAAVSYCPPIIEEEITNPAADEAGGASQVVYIDVQSMYQPQAKAED 985

  Fly  1162 E-----IILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYG 1221
            |     :::..| |......::|................|||...:. |..:.:|......|   
  Rat   986 EQDTDPVMVAGY-KPQMRLPINPTAEDTTAEDEADKTAGYRPQANVN-TWNLVSPDSPRSTD--- 1045

  Fly  1222 VVNGEEILVILPQASEEYGPISHYYLVVVPED----KSN 1256
              :..|::......|     |:....::.|:|    |||
  Rat  1046 --SNSEVVSFGSPCS-----INSRQFLIPPKDEDSPKSN 1077

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 19/96 (20%)
I-set 36..129 CDD:254352 19/95 (20%)
IG_like 146..227 CDD:214653 17/95 (18%)
Ig 159..228 CDD:299845 13/82 (16%)
I-set 234..318 CDD:254352 22/98 (22%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 19/82 (23%)
fn3 324..404 CDD:278470 16/88 (18%)
FN3 423..514 CDD:238020 19/98 (19%)
FN3 520..610 CDD:238020 13/89 (15%)
FN3 616..707 CDD:238020 24/96 (25%)
FN3 712..810 CDD:238020 10/97 (10%)
FN3 832..907 CDD:238020 13/75 (17%)
FN3 914..1005 CDD:238020 29/107 (27%)
FN3 1012..1101 CDD:238020 18/104 (17%)
fn3 1106..1198 CDD:278470 19/106 (18%)
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
LifrNP_112310.1 FN3 332..>368 CDD:304408 5/35 (14%)
FN3 432..526 CDD:238020 25/152 (16%)
WSXWS motif 515..519 0/3 (0%)
fn3 <552..615 CDD:278470 22/74 (30%)
FN3 725..817 CDD:238020 25/94 (27%)
Box 1 motif 865..873 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 908..941 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1003..1093 15/86 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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