DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptprfb

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_009296732.1	Gene:	ptprfb / 799867	ZFINID:	ZDB-GENE-060503-530	Length:	1927	Species:	Danio rerio

Alignment Length:	2098	Identity:	975/2098 - (46%)
Similarity:	1274/2098 - (60%)	Gaps:	262/2098 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGK 74
            |:....||:||.:.::.    .|...|..:|.|::|....||||||.|.|.|:|.|.|.|.|.||
Zfish    13 PVGLPLLLLLSCIQFSS----QADSLPNFVRSPEDQTGISGGVASFVCQAAGEPKPRITWMKKGK 73

  Fly    75 KVSGTQSRYTVLE-QPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAG 138
            |||  ..|:.|:| ..|..|:|||:|:|..||:|.|||.|.|.:|: ::..|.||:.|.::.|.|
Zfish    74 KVS--SQRFEVIEFDDGSGSVLRIQPLRTHRDEAIYECTATNSLGE-INTSAKLTVLEENQIPHG 135

  Fly   139 FPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD---------GFL 194
            ||.|..||..:|:|...|..|.|.|.|||.|.|.|.|:...||: |....:|.         |.|
Zfish   136 FPTIDMGPQLKVVERTRTTTMLCAASGNPDPEITWFKDFLPVDI-NGNGRIKQLRSGGSPIRGAL 199

  Fly   195 QIENSREEDQGKYECVAENSMGTEHSKATNLYVK--------VRRVPPTFSRPPETISEVMLGSN 251
            |||||.|.|||||||||.||.||.:|...||||:        ||||||.||.|| |..|||.|.:
Zfish   200 QIENSEESDQGKYECVATNSAGTRYSAPANLYVRVIREDPRGVRRVPPRFSIPP-TNHEVMPGGS 263

  Fly   252 LNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVV 316
            :||:|:|||:|||:||||.|..:||.:.|||:|||||:|.||::|.||||:|.|:||.|::.:.|
Zfish   264 VNLTCVAVGAPMPYVKWMTGEVELTKDEEMPVGRNVLELTNIRQSTNYTCVAISSLGMIEATAQV 328

  Fly   317 KVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRA 381
            .|::||..||.:.::|.|||||.|.|....||.:.||:|||:.|.::..|.|:.|:.|..|.:..
Zfish   329 SVKALPKPPTSLTVTETTATSVTLTWDSGNPEPVSYYIIQYRAKTSDTNFQEVDGVATTRYSIGG 393

  Fly   382 LSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPE 446
            ||||:||||.|:|||||||||||.|....||:     ....|.|.:||.|.||:|||::.|||||
Zfish   394 LSPYSEYEFRVMAVNNIGRGPPSEPVETRTGE-----QAPSSPPLHVQARMLSASTMLVQWEPPE 453

  Fly   447 TPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPV 511
            .||||:.||::|||::.:.|.::|.....|:|.|||:|.||....|::||..:||:|.||.|..:
Zfish   454 EPNGQIRGYRIYYTSDLDAPLSAWQKHNTDDSRLTTISSLTTGITYSLRVLGFTSVGDGPPSDVL 518

  Fly   512 QVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYEL-YWNDTYANQAHHKRISNSEA 575
            |||.|||||:|||:|.|....:|.:.|.|..|.  .:.|:.||| ||.....|:. |.....:.:
Zfish   519 QVKTQQGVPAQPSSFEAEAELDTRILLTWLWPV--QDPIIKYELQYWEADSDNKI-HVTFDPAGS 580

  Fly   576 YTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPP 638
            |.::||.|||||...|||||:.|:|..|.||..||.|.  .|||:::..::.|||:|.:||:.||
Zfish   581 YAVEGLKPDTLYKFSLAARSEMGQGVFTHPIEARTAQSAPSAPPQDVHLLSLSSTSIKVSWVAPP 645

  Fly   639 VERSNGRIIYYKVFFVEVGRED---DEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRS 700
            ....:|.|:.|.|.:..|..||   .|...:..:.:|.||:.|::||||::||.|.|.||.||.|
Zfish   646 AASRHGAIVRYTVSYQAVNGEDTERHEVPDIGADASSCVLEGLEKWTEYQVWVRAHTDVGPGPES 710

  Fly   701 HPIILRTQEDVPG-DPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD-EGKGFLN 763
            ..:.:||.||||| .|:.::...||||:|.|:|||||...::|.||||.:....|.: |.:|..|
Zfish   711 TAVRIRTNEDVPGAPPRKLEVEALNSTAIRVTWKPPLSGKQHGQIRGYQVIYSRLENGEPRGHPN 775

  Fly   764 --------EPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTV 820
                    ..:|.:.....|..:.||..:|.||:.|||.|.||||.||.|.||.|.|.||.:||:
Zfish   776 IMDVALPEAQWKIEESTEYEAVIAGLASETSYSVTVAAYTTKGDGARSKAKVVTTTGAVPGKPTM 840

  Fly   821 SLKIMEREPIVSIE------LEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTK----KR 875
                     |:|..      ::|:.|....|||.|||||:    :.|:||.....:.::    ..
Zfish   841 ---------IISTTVGNTALIQWQPPKDMVGELMGYRLRY----KRLEEENYEIREFSRTDDHHT 892

  Fly   876 FDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREH 940
            ..:|.:|..|.|.::..|..|:|:|.||...|||..|.|.|.|:.:...|.....:||:||....
Zfish   893 VTDLHKGATYSFHLSARNRAGLGEEYVKDIGTPEDVPSGFPLNLQVVGLTTSTTRLTWEPPALSE 957

  Fly   941 RNGIITRYDVQFHKKIDHGLGSERNMTLR----KAVFTNLEENTEYIFRVRAYTKQGAGPFSDKL 1001
            |||.|..|.|.:     ..:.|::|.|.|    :.....|..:|.|..||:|:|.:|.||.|..:
Zfish   958 RNGRIIHYIVVY-----RDINSKQNSTNRTSDTQMTIQGLRPDTTYDIRVQAFTSKGGGPISPSI 1017

  Fly  1002 IVETERDMGRAP---MSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVG 1063
               ..|.|..:|   .|...:|..:.:..:.||...:....:.:||.|...:||...:.:.|.:
Zfish  1018 ---QSRTMSTSPAFATSFGVKAVMKTSVLLTWEVPENYKSQVPFKILYNQQSVEVQGNLKRKLI- 1078

  Fly  1064 LTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPP 1128
                   ..|:....|:..:.:| .|..|.|.::|::|..|
Zfish  1079 -------TRLQPDTDYSFVLMSR-GNSAGGLQQQVSIRTAP------------------------ 1111

  Fly  1129 IRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSD 1193
                        |..|
Zfish  1112 ------------DLFK------------------------------------------------- 1115

  Fly  1194 YSYRPPTKITVTTQMAAPQPMVKPDFYGV--VNGEEILVILPQASEEYGPISHYYLVVVPEDKSN 1256
                                 .||..|..  .|..::.:.||:.... .|:..||:||||..:::
Zfish  1116 ---------------------TKPVLYTADQTNNGKLTINLPKVPTS-APVRCYYIVVVPVSQTS 1158

  Fly  1257 LHK--IPDQFLTDDLLPG--------RNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNR 1311
            ..:  .||:...|:||..        |.:......||||||.  .::|.||.||...||..|.||
Zfish  1159 SRQWINPDEMELDELLESSEGAHLRRRRRHTDTVRPYIAAKL--STLPETFTLGDELDYSGFINR 1221

  Fly  1312 KLEREKRYRIFVRA-------VVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPE 1369
            .|...:.::.||.|       |....::..:::||:|:.:.:                    :.|
Zfish  1222 PLPNNQHFQCFVMAELKDQYPVTANEKQRTFSASPYSDPIIV--------------------QGE 1266

  Fly  1370 VSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVV-------KRRRQPCKTPDQAAVTRPLMAA 1427
            ..:.|:.|:||:|||:.|::....|:   :||:.::       ::|..|....|.:...:..:.|
Zfish  1267 NQMQRSVDQPEMLWVMGPVLAVVLII---IIVIAILLFKSKQERKRASPLPKDDHSGGVKDCLLA 1328

  Fly  1428 DLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTW 1492
                  :.||||:|||||:|||||..||||.:||.|:||||||:||..:||||||||:|||||||
Zfish  1329 ------SSSDPVEMRRLNYQTPGMREHPPISVSELADHIERLKANDALRFSQEYESIDPGQQFTW 1387

  Fly  1493 DNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFV 1557
            :|||||.||.|||||||.|||||||.|..|:||.||||||:||.|||||.|||:||||||.||..
Zfish  1388 ENSNLEVNKPKNRYANVIAYDHSRVVLTPVDGVPGSDYINSNYIDGYRKQNAYIATQGPLPETLS 1452

  Fly  1558 DFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCR 1622
            |||||.||.:.:||||||||||::|:|||||||.|||||||.|.||:.:..||||||:|||.|.:
Zfish  1453 DFWRMIWEQRASTIVMMTRLEEKSRVKCDQYWPIRGTETYGMIQVTMLDAVELATYSVRTFALYK 1517

  Fly  1623 QGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVID 1687
            .|.:::||::|.||.||||||||::|.|.|.||||.:|..||::||::||||||||||||:||||
Zfish  1518 NGSSEKREVRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPPDAGPMVVHCSAGVGRTGCFIVID 1582

  Fly  1688 SMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKL 1752
            :|||||||||.:||||||||:|:||||||||||||||||:|:|||..||.||||||||:.|:|||
Zfish  1583 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLEAATCGNTEVPARNLYAHIQKL 1647

  Fly  1753 LITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGS 1817
            .....|||::.||:|||:|:|.|..:|:|::|||||||.|||||:|:|:||:||.|.||.|:|||
Zfish  1648 TQPSAGETVTAMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPFESTRVCLQPIRGVEGS 1712

  Fly  1818 DYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHER 1882
            ||:|||.|||||.:.||||.|||:.:..|||||||||||||||||||||:|||||||.||||.||
Zfish  1713 DYINASCIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER 1777

  Fly  1883 SVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQV 1947
            |.||||:||||:||||||||.||||||||||||.|||:|||||.|||||||||:|||||||||||
Zfish  1778 SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV 1842

  Fly  1948 HKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQ 2012
            |||||||||||||||||||||||:|||||||||||||:||||:|:||||:.||:|||||||||||
Zfish  1843 HKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDLFQTVKTLRTQRPAMVQTEDQ 1907

  Fly  2013 YHFCYRAALEYLGSFDNY 2030
            |..|||||||||||||:|
Zfish  1908 YQLCYRAALEYLGSFDHY 1925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	44/94 (47%)
		I-set	36..129	CDD:254352	44/93 (47%)
		IG_like	146..227	CDD:214653	42/89 (47%)
		Ig	159..228	CDD:299845	39/77 (51%)
		I-set	234..318	CDD:254352	48/83 (58%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	38/67 (57%)
		fn3	324..404	CDD:278470	41/79 (52%)
		FN3	423..514	CDD:238020	44/90 (49%)
		FN3	520..610	CDD:238020	36/90 (40%)
		FN3	616..707	CDD:238020	35/93 (38%)
		FN3	712..810	CDD:238020	43/107 (40%)
		FN3	832..907	CDD:238020	24/84 (29%)
		FN3	914..1005	CDD:238020	29/94 (31%)
		FN3	1012..1101	CDD:238020	18/91 (20%)
		fn3	1106..1198	CDD:278470	2/91 (2%)
		PTPc	1476..1731	CDD:214550	186/254 (73%)
		PTPc	1503..1731	CDD:238006	164/227 (72%)
		PTPc	1763..2022	CDD:214550	207/258 (80%)
		PTPc	1791..2022	CDD:238006	190/230 (83%)
ptprfb	XP_009296732.1	I-set	35..126	CDD:254352	44/93 (47%)
		Ig2_RPTP_IIa_LAR_like	155..233	CDD:319301	39/78 (50%)
		Ig3_RPTP_IIa_LAR_like	261..329	CDD:143216	38/67 (57%)
		FN3	334..423	CDD:238020	45/88 (51%)
		FN3	430..522	CDD:238020	45/91 (49%)
		FN3	527..615	CDD:238020	36/90 (40%)
		FN3	623..717	CDD:238020	35/93 (38%)
		fn3	725..823	CDD:306538	36/97 (37%)
		FN3	835..916	CDD:238020	24/93 (26%)
		FN3	933..1021	CDD:238020	28/95 (29%)
		PTPc	1397..1626	CDD:238006	164/228 (72%)
		PTPc	1687..1917	CDD:238006	190/229 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	418	1.000	Domainoid score	I627
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1236	1.000	Inparanoid score	I178
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm25136
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860