DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Lpo

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_536345.2	Gene:	Lpo / 76113	MGIID:	1923363	Length:	710	Species:	Mus musculus

Alignment Length:	764	Identity:	144/764 - (18%)
Similarity:	242/764 - (31%)	Gaps:	280/764 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1144 KVFVDSQG----FSQTQIVPKREI--ILKH------------YVKTHTINELSPFTT----YNVN 1186
            |.|:||:.    ...|:|...|.:  .|||            .|...::.:||.|.|    ..::
Mouse    47 KAFLDSRDRLKMAMTTKIHSTRHLSDYLKHAKGRTRTAIRSGQVWEESLKKLSQFLTNVTGQGLD 111

  Fly  1187 VSAIPSDYSYRPPTKITVTTQMAAPQPMV-------KPDFYGVVNG----------EEILVI--- 1231
            ::.:..:....||.. |:|..:::|...:       |....|..|.          |:.|.:
Mouse   112 LTLLSWEAGCDPPAP-TMTCNISSPYRTITGYCNNRKNPALGSANRALARWLPAEYEDGLSLPYG 175

  Fly  1232 -----------LPQASEEYGPISHYYLV--VVPEDKSNLHKIPDQFLTDDL--LPGRNKPERPNA 1281
                       |||..|....|:.|...  |:.:.:|.|.....|.:..|:  .|   :.|..:.
Mouse   176 WTPGKMRNGFPLPQPREVSNQIAAYLNEEDVLDQKRSMLFMQWGQIVDHDMDFAP---ETEMGSD 237

  Fly  1282 PYIAAKFPQRSI------PFTFHLGSGDDYHNFTNRKLEREKRYRIFVRA--VVDTPQKHLYTS- 1337
            .|..|:..:..|      |..|..|         :.||:.:.:...|.||  |..||.   |.|
Mouse   238 TYTKAQCDEHCIQGDNCFPIMFPPG---------DPKLKTQGKCMPFFRAGFVCPTPP---YKSL 290

  Fly  1338 -----SPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVN-RNKDEPEILWVVLPLM-VSTFIV 1395
                 :..:.||...:..:|              ||.::.. ||...|      |.|| |:..:.
Mouse   291 AREQINALTSFLDASLVYSP--------------EPSLANRLRNLSSP------LGLMAVNEEVS 335

  Fly  1396 STALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPV------------------DMR 1442
            .........||.:..||:..:..|.....:|.|..|    |:.:                  ::.
Mouse   336 DNGRPFPPFVKMKPSPCEVINATAGVPCFLAGDSRA----SEQILLATSHTLFIREHNRLATELS 396

  Fly  1443 RLN--------FQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEY----ESIEPGQQFTWDNS 1495
            |||        :|....|....|.|:.|.:::..|..::.||:...|    ||::|
Mouse   397 RLNPHWDRETLYQEARKIMGAFIQITTFRDYLPILLGDEMQKWIPPYQGYNESVDP--------- 452

  Fly  1496 NLEHNKSKNRYANV--TAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAY----VATQGPLQE 1554
                     |.:||  .|.....:::|:..               ||....|    ..::.||..
Mouse   453 ---------RISNVFTFALRFGHLEIPSTV---------------YRLDENYQPWGSESELPLHT 493

  Fly  1555 TFVDFWRMCWELKTATIVMMTR--LEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRT 1617
            .|.:.||:   :|...|..:.|  |.:..::.......|  .|...::|        ...::|..
Mouse   494 VFFNTWRL---VKDGGIDPLVRGLLAKNAKLMHQNKMMT--GELRNKLF--------QPNHTIHG 545

  Fly  1618 FQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGC 1682
            |.|........|           |||.|.:.:     .|....|:.|::
Mouse   546 FDLASINIQRSR-----------DHGQPGYNS-----WRAFCGLSQPKT---------------- 578

  Fly  1683 YIVIDSMLERMKHE----KIIDIYG-----------------H-------VTCLRAQR------- 1712
               ::.:...||:|    |::|:||                 |       :|||..|:
Mouse   579 ---LEELSAVMKNEVLAKKLMDLYGTPSNIDIWLGAVAEPLVHRGRVGPLLTCLLGQQFQRIRDG 640

  Fly  1713 ------NYMVQTEDQYIFIHDAILEAIIC---GVTEVPAR----NLHTH 1748
                  |..|.||.|...:.......::|   |:.:||..    |.:.|
Mouse   641 DRFWWENPGVFTEKQRESLQKMSFSRLVCDNTGIDKVPLNPFQANAYPH 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470	15/75 (20%)
		PTPc	1476..1731	CDD:214550	53/307 (17%)
		PTPc	1503..1731	CDD:238006	48/276 (17%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
Lpo	NP_536345.2	myeloperoxidase_like	281..692	CDD:188656	95/517 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900