DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptpru

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_012812827.1 Gene:ptpru / 733850 XenbaseID:XB-GENE-922688 Length:1439 Species:Xenopus tropicalis


Alignment Length:1670 Identity:429/1670 - (25%)
Similarity:673/1670 - (40%) Gaps:398/1670 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   504 AGPMSTPVQVKAQQGVPSQPSNFRA-TDIGETAVT------LQWTKPTHSSENIVHYELYWND-- 559
            |.|:..|::.:    .|:....|.| .|||...||      ..|        .:||:....||  
 Frog    11 AAPLCFPLETE----TPTAGCTFEAHGDIGPCEVTQGTLDDFDW--------ELVHFPNKDNDLA 63

  Fly   560 --TY--ANQAHH---KR-------ISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRT 610
              :|  .|.:.|   ||       :|.::.:.|...|       .|.:|..||.|.    :.|..
 Frog    64 PGSYLMVNSSQHAPGKRAQLLFQPLSENDTHCLQFSY-------LLHSRDARGPGT----LRVYV 117

  Fly   611 KQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVL 675
            :..|.|..  ||:          |   .|....|                               
 Frog   118 RVNGGPLG--TAV----------W---EVSGPRG------------------------------- 136

  Fly   676 DELKRWTEYKI-----WVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPP 735
               |:|.:.::     |          |..:.|:.  :.:|.|.||                   
 Frog   137 ---KQWHQAELAVSTFW----------PSEYQILF--EAEVSGTPQ------------------- 167

  Fly   736 LEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTG---LQPDTKYSIQVAALTRK 797
                      || |...::.         .|.:.......|:..|   :......:.|..|..|.
 Frog   168 ----------GY-IGLDDIL---------LFSYPCTRAPHFSRLGEVEVNAGQNATFQCPASGRA 212

  Fly   798 GDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALK 862
            .||:  :.::.:..||:.....:. ::.....:||.:|:...|::                    
 Frog   213 NDGE--SFLLQRQNGGITSAGVIQ-RVSHHRFLVSFQLQDAGPSE-------------------- 254

  Fly   863 EEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTP---GGPPSNITIRFQ 924
                          .:|.|.|......||.::  ..:..||...||...|   ...|:.:.::..
 Frog   255 --------------QDLYRCVSCSIHGAGVSN--FAELVVKEPPTPIAPPQLLRAGPTYLIVQLN 303

  Fly   925 TPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERN-MTLRKAVFTNLEENTEYIFRVRA 988
            |..::           .:|.|.|.::::  ::......||: :|.......:|:.:::|...| .
 Frog   304 TRSII-----------GDGPIVRREIEY--RVSGSSWKERHAVTAHTYKLWHLDPDSQYHISV-L 354

  Fly   989 YTKQGAG----PFSDKLIVETE-RDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKI---- 1044
            .|:.|.|    | ...||..|: .:..|||..|...|...:...:.||.|       |:.|    
 Frog   355 LTRPGEGGTGKP-GPALISRTKCAEPMRAPKGLSCSAEQPRQLTLQWEAV-------GFNITRCH 411

  Fly  1045 -FYTM----TAVEDLDDWQTKTVGLTESADLVNLEKFAQY-AVAIAARFKNGLGRLSEKVTVRIK 1103
             |..|    |.:..:.|..|...|.::    ..|...|.| ||.......|..||...|......
 Frog   412 TFSVMLCYHTELSSIQDCVTAEGGSSQ----YTLHGLAPYRAVHCHLIITNPEGRKEGKEVTCHT 472

  Fly  1104 PEDVPLNLRAHDV----STHSMTLSWSPPIRLTPV--NYKISFDAMKVFVDSQGFSQTQIVPK-R 1161
            .||||.::.:..:    ...::.|.|..|:....|  .|:|.:.    .::|...|.:  ||. |
 Frog   473 QEDVPGSIASESLILVPQEDAVLLMWDKPVEPNGVLTQYEIGYQ----IIESSDPSVS--VPGIR 531

  Fly  1162 EIILKHYVKT-HTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAA--------PQPMVKP 1217
            ..:.|...:| |.:..|.|.|||.::|.|..|. .|.|.....:||.::|        |.|:.:.
 Frog   532 GTVCKLPNETSHLLTNLLPGTTYLLSVRARNSK-GYGPSVLTELTTNISAPTFDYSDLPPPLDET 595

  Fly  1218 DFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHK---IPDQFLTDDLLPGRNKPERP 1279
            |       :.|.|:|..|.....|:|.|.::|..|......:   :|..|      ||....|..
 Frog   596 D-------KTITVLLRPAQGRGSPVSFYQVLVEGETSPRSRRELGVPGCF------PGAASYEEA 647

  Fly  1280 ----NAPYIAAKFPQRSIP--FTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSS 1338
                ::.|:.|:.|...:|  ..|.:|....|..:.|..|:..:.|.|:::|.    ..|     
 Frog   648 EIEGSSSYVGAEIPPTDLPRDTPFIVGDNRSYGGYWNPPLDPRRGYLIYLQAA----SHH----- 703

  Fly  1339 PFSEFLSLDMREAPPGE------RPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVST 1397
                          .||      |..|..|...::......:..||..::..:....:..||:..
 Frog   704 --------------RGETRLNCVRIARKAPCKDSQRSSMAPQRSDEMGLVLGICAGGLVVFIILL 754

  Fly  1398 ALIVLCVVKRRRQ------------------------PCKTP--------------DQAA----- 1419
            ..::|.|.|.|.|                        .|..|              ::||     
 Frog   755 GAVILIVRKGRTQFSYAYYPKPIGLTKSALPSRHENSNCAAPREHTKMTDQPTLLQEEAALAFLH 819

  Fly  1420 -----VTRPLM------AADLGAGP-----TPSDPVDMRRLNFQTPGMISHPPIPISEFANHIER 1468
                 |..|.:      ::.||..|     ....|....:|         ||.:.:::...||.:
 Frog   820 SYNTRVGEPRVGSVTESSSLLGGSPRRGGGRKGSPYHTGQL---------HPAVRVADLLQHINQ 875

  Fly  1469 LKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINA 1533
            :|..:...|.|||||.     |.||.|. :.:|.|.|......|:..||:|..::....|:.|||
 Frog   876 MKVAEGYGFKQEYESF-----FDWDVSK-KKDKGKGRQDIPPNYERHRVRLHPLQAECSSEEINA 934

  Fly  1534 NYCD------GYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR 1592
            ||.|      ||.:.|.::|||||.|:...|||||.|:...::|||:|:|.|..|:||.:|||..
 Frog   935 NYIDIRINREGYHRSNHFIATQGPKQDMIYDFWRMVWQEHVSSIVMITKLVEVGRVKCSKYWPDT 999

  Fly  1593 GTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRR 1657
             ::|||.|.||:..|:.||.||:||..|.|:|:..|.|:||..|.:|||||||.|....|.|:||
 Frog  1000 -SDTYGDIRVTLLNTETLAEYSVRTLTLERRGYTVRHEVKQFHFLSWPDHGVPYHATGLLAFIRR 1063

  Fly  1658 CRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQY 1722
            .::.|||::|||:||||||.||||||||:|.||:..:.|.::|||..|..|.::|..||||::||
 Frog  1064 VKSSTPPDAGPVVVHCSAGAGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRINMVQTQEQY 1128

  Fly  1723 IFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDSSKFVTAN 1785
            :|||||||||.:||.|.:||.:.....:::|..:.....:.:..||:.|::|  ::...:...|.
 Frog  1129 VFIHDAILEACLCGDTAIPACDFRQTYKEMLQIDTQSNSTHLRDEFQTLNSVTAQLGVEECSIAL 1193

  Fly  1786 LPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWR 1850
            ||.|:.|||.:.:||.:.:...|...||.:.|:|:||...|.|...|..|....|:|:...||||
 Frog  1194 LPHNRDKNRSMDVLPPDRALPLLLSAHGEDTSNYINAVLTDSYTRSSNVIITVHPLQNTITDFWR 1258

  Fly  1851 MLWEHNSTIVVMLTKLKEMGRE-KCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARD 1914
            :::::..:.||||.:|.:.... .|.||||.....||....|..::.........|.|:|.:...
 Frog  1259 LVYDYGCSTVVMLNQLNQSNSAWPCLQYWPDSGICRYGPMEVQFVSGSVEEDVVTRVFRVQNIAR 1323

  Fly  1915 GSSRTVRQFQFIDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLS 1978
            .....|:.||::.| |.:..|.|...|:..:..|.:.:|| .::....|||..|.||||.|...:
 Frog  1324 DEHLMVKHFQYLRWSPYRETPDSKRSFLQLLSLVEQWQEQ-NREHRTLVHCLNGGGRSGTFCACA 1387

  Fly  1979 IVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY 2023
            ::.:.::...|:|||..|:.||:.:|.||:|.|||.|||..||||
 Frog  1388 MIHDMIRCHCVMDVFYAVKTLRNIKPNMVETLDQYRFCYEIALEY 1432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020 3/9 (33%)
FN3 520..610 CDD:238020 27/112 (24%)
FN3 616..707 CDD:238020 11/95 (12%)
FN3 712..810 CDD:238020 14/100 (14%)
FN3 832..907 CDD:238020 10/74 (14%)
FN3 914..1005 CDD:238020 17/95 (18%)
FN3 1012..1101 CDD:238020 24/98 (24%)
fn3 1106..1198 CDD:278470 26/99 (26%)
PTPc 1476..1731 CDD:214550 126/260 (48%)
PTPc 1503..1731 CDD:238006 115/233 (49%)
PTPc 1763..2022 CDD:214550 84/262 (32%)
PTPc 1791..2022 CDD:238006 76/232 (33%)
ptpruXP_012812827.1 MAM 27..183 CDD:366209 46/274 (17%)
IG_like 192..278 CDD:214653 17/124 (14%)
fn3 287..366 CDD:365830 15/92 (16%)
fn3 490..568 CDD:365830 23/84 (27%)
PTP_DSP_cys 931..1141 CDD:391942 111/210 (53%)
PTP_DSP_cys 1227..1431 CDD:391942 67/204 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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