DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and PTPRS

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_002841.3 Gene:PTPRS / 5802 HGNCID:9681 Length:1948 Species:Homo sapiens


Alignment Length:2113 Identity:981/2113 - (46%)
Similarity:1280/2113 - (60%) Gaps:272/2113 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 IAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVWRKNGK 74
            :..:.|||:.|:..     ..|..||..|::|::| ||. ||||||.|.|.|||.|.:.|.|.||
Human    13 VGPMGLLVVLLVGG-----CAAEEPPRFIKEPKDQIGVS-GGVASFVCQATGDPKPRVTWNKKGK 71

  Fly    75 KVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGF 139
            ||:..:......::..| ::|||:|:|..||:..|||||:|.||: ::..|.||:...|:.|:||
Human    72 KVNSQRFETIEFDESAG-AVLRIQPLRTPRDENVYECVAQNSVGE-ITVHAKLTVLREDQLPSGF 134

  Fly   140 PVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD------------G 192
            |.|..||..:|:|...|..|.|.|.|||.|.|.|.|:...||.|.....:|.            |
Human   135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRG 199

  Fly   193 FLQIENSREEDQGKYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETISEVMLGSNLN 253
            .||||:|.|.|||||||||.||.|..:|...||||:    ||||.|.||..|.: .|:|.|.|:|
Human   200 ALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMS-HEIMPGGNVN 263

  Fly   254 LSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKV 318
            ::|:|||||||:||||:|:||||||::||:|||||:|.::::||||||:|.|:||.|::|:.:.|
Human   264 ITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 328

  Fly   319 QSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALS 383
            :|||.||....::|.||||:.:.|....|:.:.||||:||.|:.:..:.....|.|..|.:..||
Human   329 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLS 393

  Fly   384 PYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETP 448
            |.:|||.:|.|||:||:||||......||:     ....|||||||.|.||::||::.||.|..|
Human   394 PNSEYEIWVSAVNSIGQGPPSESVVTRTGE-----QAPASAPRNVQARMLSATTMIVQWEEPVEP 453

  Fly   449 NGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQV 513
            ||.:.||:||||.....|..:|....||:|.||||..|.....|||||.|:||:|.||:|.|:||
Human   454 NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQV 518

  Fly   514 KAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTL 578
            |.|||||.||.|.||....||::||.|:.|  ..|:|:.|||.:.:....:...:....:.:|.:
Human   519 KTQQGVPGQPMNLRAEARSETSITLSWSPP--RQESIIKYELLFREGDHGREVGRTFDPTTSYVV 581

  Fly   579 DGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPPVER 641
            :.|.|:|.|...|||||.:|.||.||.:..||.|.  .|||:::..::..||.|.:||.|||.|.
Human   582 EDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPET 646

  Fly   642 SNGRIIYYKVFFVEVGREDDE--------ATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGP 698
            .||.::.|.|.:..:|.||.|        .||     |.|:|:.|::||:|:|..:|.|.||.||
Human   647 HNGALVGYSVRYRPLGSEDPEPKEVNGIPPTT-----TQILLEALEKWTQYRITTVAHTEVGPGP 706

  Fly   699 RSHPIILRTQEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFL 762
            .|.|:::||.|||| ..|:.|:|..||:|:|.|.|:.|....::|.||||.:|  .:|.||....
Human   707 ESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVH--YVRMEGAEAR 769

  Fly   763 NEPFKFDVV---------DTLEFN--VTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPV 816
            ..|...||:         ||.|:.  :|.|||:|.|||.|||.|.||||.||...||.|.|.|..
Human   770 GPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLG 834

  Fly   817 RPTVSLKIMEREPIVSIELEWERPAQT-YGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLE 880
            |||:|   :::.|..|:...||.||.| ..::.||||::|.:|......:...|...:.....:.
Human   835 RPTLS---VQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVH 896

  Fly   881 RGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQ-TPDVLCVTWDPPTREHRNGI 944
            :|..|.||:|..:..|:|:|..::...||.||.|.|..:..... :...:.:.|.||....|||.
Human   897 KGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGA 961

  Fly   945 ITRYDVQFHKKIDHGLGSERNMTLRKA---------VFTNLEENTEYIFRVRAYTKQGAGPFSDK 1000
            |.:|.|...:.  ..||..|...|..|         ....|:.:|.|..:|||:|::|.||||  
Human   962 IVKYTVAVREA--GALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFS-- 1022

  Fly  1001 LIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLT 1065
                                          .||.       |:.|                    
Human  1023 ------------------------------PPVR-------YRTF-------------------- 1030

  Fly  1066 ESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIR 1130
                                        |.::|:        |.|.:...:...|:.|||..|..
Human  1031 ----------------------------LRDQVS--------PKNFKVKMIMKTSVLLSWEFPDN 1059

  Fly  1131 L-TPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDY 1194
            . :|..|||.::.:.:.||.:        ..:::|      ||    |.|.|.||..::...|..
Human  1060 YNSPTPYKIQYNGLTLDVDGR--------TTKKLI------TH----LKPHTFYNFVLTNRGSSL 1106

  Fly  1195 SYRPPTKITVTTQM----AAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKS 1255
            .....| :|..|..    ..|....|||..|.     |:|.||...... |:..|::|:||..||
Human  1107 GGLQQT-VTAWTAFNLLNGKPSVAPKPDADGF-----IMVYLPDGQSPV-PVQSYFIVMVPLRKS 1164

  Fly  1256 NLHKIPDQFLT----------DDLLPGRNKPERPN----------APYIAAKFPQRSIPFTFHLG 1300
            .    ..||||          ::|:...::.:|.:          .|||||:|  ..:|.|||.|
Human  1165 R----GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARF--SVLPPTFHPG 1223

  Fly  1301 SGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWP 1365
            ....|..|.||.||...||.:||.||:...:. .:.:||||:...||           .|||   
Human  1224 DQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEP-TFAASPFSDPFQLD-----------NPDP--- 1273

  Fly  1366 AEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQP-CKTPDQAAVTRPLM-AAD 1428
             :|.|.     .|..::||:.|::...||:   .||:.::..:.:| .|..|....|:.|: .||
Human  1274 -QPIVD-----GEEGLIWVIGPVLAVVFII---CIVIAILLYKNKPDSKRKDSEPRTKCLLNNAD 1329

  Fly  1429 LGAGPTPSDPVDMRRLNFQTP----------------GMISHPPIPISEFANHIERLKSNDNQKF 1477
            | |...|.|||:|||:|||||                .|:|||||||::.|.|.||||:||:.|.
Human  1330 L-APHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKL 1393

  Fly  1478 SQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKH 1542
            |||||||:|||||||::||||.||.|||||||.|||||||.|..:||::|||||||||.||||..
Human  1394 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQ 1458

  Fly  1543 NAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITET 1607
            |||:||||||.|||.|||||.||.::|||||||||||::|||||||||.|||||||.|.||:.:|
Human  1459 NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1523

  Fly  1608 QELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVH 1672
            .||||:.:|||.|.:.|.:::||::|.|||||||||||::|.|||.||||.:...||::||::||
Human  1524 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH 1588

  Fly  1673 CSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGV 1737
            ||||||||||:||||:||||:|.||.:|:|||||.:|:||||||||||||.|||:|:|||:.||.
Human  1589 CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGN 1653

  Fly  1738 TEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYE 1802
            ||||||:|:.::|||...||||.::|||:|||:|:|.|..:|:|::|||||||.|||||:|:|||
Human  1654 TEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1718

  Fly  1803 SSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLK 1867
            |:||.|.||.|:|||||:|||||||||.:.||||.|||:.:..|||||||||:|||||||||||:
Human  1719 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR 1783

  Fly  1868 EMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQG 1932
            |||||||.||||.|||.||||:||||:||||||||.||||||||||||.|||||||||.||||||
Human  1784 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQG 1848

  Fly  1933 VPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVR 1997
            ||||||||||||||||||||||||||||:|||||||||:|||||||||||||:||||:|:||||:
Human  1849 VPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1913

  Fly  1998 ILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY 2030
            :||:||||||||||:|.|||:||||||||||:|
Human  1914 MLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHY 1946

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151 42/93 (45%)
Ig strand B 53..57 CDD:409353 3/3 (100%)
Ig strand C 66..70 CDD:409353 0/3 (0%)
Ig strand E 93..97 CDD:409353 1/3 (33%)
Ig strand F 108..113 CDD:409353 3/4 (75%)
Ig strand G 122..125 CDD:409353 0/2 (0%)
Ig 141..228 CDD:472250 43/98 (44%)
Ig strand B 157..161 CDD:409353 1/3 (33%)
Ig strand C 170..174 CDD:409353 1/3 (33%)
Ig strand E 192..196 CDD:409353 2/3 (67%)
Ig strand F 206..211 CDD:409353 4/4 (100%)
Ig strand G 218..221 CDD:409353 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 46/81 (57%)
Ig strand A 237..239 CDD:409401 1/1 (100%)
Ig strand A' 244..248 CDD:409401 1/3 (33%)
Ig strand B 251..259 CDD:409401 3/7 (43%)
Ig strand C 264..270 CDD:409401 4/5 (80%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 2/3 (67%)
Ig strand E 286..291 CDD:409401 3/4 (75%)
Ig strand F 298..305 CDD:409401 5/6 (83%)
Ig strand G 309..318 CDD:409401 2/8 (25%)
FN3 322..411 CDD:238020 36/88 (41%)
FN3 <382..747 CDD:442628 164/375 (44%)
FN3 712..810 CDD:238020 46/109 (42%)
FN3 832..898 CDD:214495 19/66 (29%)
FN3 <867..1269 CDD:442628 92/426 (22%)
fn3 914..998 CDD:394996 26/93 (28%)
R-PTPc-LAR-1 1498..1735 CDD:350401 167/236 (71%)
R-PTP-LAR-2 1784..2021 CDD:350402 197/236 (83%)
PTPRSNP_002841.3 I-set 33..124 CDD:400151 42/93 (45%)
Ig strand B 50..54 CDD:409353 3/3 (100%)
Ig strand C 63..67 CDD:409353 0/3 (0%)
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 68..72 2/3 (67%)
Ig strand E 86..93 CDD:409353 2/7 (29%)
Ig strand F 104..109 CDD:409353 3/4 (75%)
Ig strand G 117..120 CDD:409353 0/2 (0%)
IgI_2_RPTP_IIa_LAR_like 137..235 CDD:409400 43/97 (44%)
Ig strand A' 143..147 CDD:409400 1/3 (33%)
Ig strand B 150..159 CDD:409400 3/8 (38%)
Ig strand C 164..170 CDD:409400 3/5 (60%)
Ig strand C' 172..174 CDD:409400 0/1 (0%)
Ig strand D 183..187 CDD:409400 1/3 (33%)
Ig strand E 199..204 CDD:409400 3/4 (75%)
Ig strand F 213..220 CDD:409400 6/6 (100%)
Ig strand G 223..234 CDD:409400 4/10 (40%)
IgI_3_RPTP_IIa_LAR_like 248..329 CDD:409401 46/81 (57%)
Ig strand A 248..250 CDD:409401 1/1 (100%)
Ig strand A' 254..258 CDD:409401 1/3 (33%)
Ig strand B 261..269 CDD:409401 3/7 (43%)
Ig strand C 274..280 CDD:409401 4/5 (80%)
Ig strand C' 282..284 CDD:409401 0/1 (0%)
Ig strand D 287..291 CDD:409401 2/3 (67%)
Ig strand E 296..301 CDD:409401 3/4 (75%)
Ig strand F 308..315 CDD:409401 5/6 (83%)
FN3 318..>724 CDD:442628 177/417 (42%)
Ig strand G 319..328 CDD:409401 2/8 (25%)
FN3 <671..>981 CDD:442628 116/321 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..724 13/23 (57%)
FN3 1037..>1097 CDD:238020 20/77 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1340 11/29 (38%)
R-PTPc-S-1 1370..1651 CDD:350473 199/280 (71%)
R-PTP-S-2 1653..1942 CDD:350475 227/288 (79%)

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