DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and PTPRM

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_016881383.2 Gene:PTPRM / 5797 HGNCID:9675 Length:1532 Species:Homo sapiens


Alignment Length:1764 Identity:498/1764 - (28%)
Similarity:743/1764 - (42%) Gaps:411/1764 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   402 PPSAPATCTTGDFSF-------GGTKMESAPRN-VQVRTLSSSTMVITWEPPETPNGQVTGYKVY 458
            |.|....||||...|       |.::.|....| .||.||:..|     ..|..|:|.      :
Human    40 PDSDDEDCTTGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPT-----SDPWMPSGS------F 93

  Fly   459 YTTN-SNQPEASWNSQMVDNSELTTVSELTPHAI---YTVR---------VQAYTSMGAGPMSTP 510
            ...| |.:||.. .:.::    |..:.|...|.|   |.|.         :..|..:..||:..|
Human    94 MLVNASGRPEGQ-RAHLL----LPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNP 153

  Fly   511 VQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEA 575
            :     ..:...|:  |..:..|.|::..|..         .|::.:.  .....|...::..|.
Human   154 I-----WNISGDPT--RTWNRAELAISTFWPN---------FYQVIFE--VITSGHQGYLAIDEV 200

  Fly   576 YTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVE 640
            ..|                   |...|..|..:|.       :|:...|....|...|.:     
Human   201 KVL-------------------GHPCTRTPHFLRI-------QNVEVNAGQFATFQCSAI----- 234

  Fly   641 RSNGRIIYYKVFFVEVGREDDEATTMTLNMTSI--------VLDELKRWT-EYKIWVLAGTSVGD 696
               ||.:.....::: |.:..:|....:.:||.        |::..||.. :|:..:  .|..|.
Human   235 ---GRTVAGDRLWLQ-GIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMI--RTEGGV 293

  Fly   697 GPRSHPIILRTQEDVP-GDPQ--DVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELR-DE 757
            |..::..::..:..|| ..||  .|.||.|        |   ::.:.|.|.....|.|:|:. ..
Human   294 GISNYAELVVKEPPVPIAPPQLASVGATYL--------W---IQLNANSINGDGPIVAREVEYCT 347

  Fly   758 GKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSA---AIVVKTPGGVPVRPT 819
            ..|..|:.   ..||:..:.:..|.|||:|.|.| .|||.|:|...:   |:..:|....|:|..
Human   348 ASGSWNDR---QPVDSTSYKIGHLDPDTEYEISV-LLTRPGEGGTGSPGPALRTRTKCADPMRGP 408

  Fly   820 VSLKIME---REPIVSIELEWERPAQTYGELRGYRL------RWGVKDQALKEEML-----SGPQ 870
            ..|:::|   |:    |.:.||...........|.|      :.|.::| ::||:.     |.||
Human   409 RKLEVVEVKSRQ----ITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ-VREEVSWDTENSHPQ 468

  Fly   871 MTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQT-PDVLCVTWD 934
            .|   ..||........::...|..|..:....|.||.|..||..|:. :|:..| .:.:.:.|.
Human   469 HT---ITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTE-SIQGSTFEEKIFLQWR 529

  Fly   935 PPTREHRNGIITRYDV------QFHKKID--------HGLGSERNMTLRKAVFTNLEENTEYIFR 985
            .||:.:  |:||.|::      .|..:||        ..||:|.:.     :|..|...|.|.|.
Human   530 EPTQTY--GVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF-----LFFGLYPGTTYSFT 587

  Fly   986 VRAYTKQGAGP-----FSDKL------IVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKL 1039
            :||.|.:|.||     |:.|:      ..|.|..:.:          ::.|..:..:|..|||..
Human   588 IRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQ----------TDNTVTVMLKPAHSRGAP 642

  Fly  1040 LGYKIFYTMTAVEDLDDWQTKTVGLT---------ESADLVNLEKFAQYAVAIAARFKNGLGRLS 1095
            :.   .|.:...|:......||..:.         ::|.|:|    :||  ..||.|.....:.:
Human   643 VS---VYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLN----SQY--YFAAEFPADSLQAA 698

  Fly  1096 EKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPK 1160
            :..|:             .|..|::.  .|:.|: |...:|:|.|.|.............|:..|
Human   699 QPFTI-------------GDNKTYNG--YWNTPL-LPYKSYRIYFQAASRANGETKIDCVQVATK 747

  Fly  1161 REIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPD------- 1218
            ..||            ::..||..:.::....|..         .|..|.|:|:.:|:       
Human   748 AAII------------VTQLTTPYIRIAPAAGDGQ---------LTGAATPKPVPEPEKQTDHTV 791

  Fly  1219 -FYGVVNGEEILVIL--------------PQASEEYGPISHYYLVVVPE-DKSNLHKIPDQFLTD 1267
             ..||:.|..:.||:              .:..|..........|:|.. |||...:        
Human   792 KIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQ-------- 848

  Fly  1268 DLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQK 1332
                |.|..|                .|:|.     |.||...|.:.....:.:....       
Human   849 ----GTNCDE----------------AFSFM-----DTHNLNGRSVSSPSSFTMKTNT------- 881

  Fly  1333 HLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVST 1397
             |.||.|.|.:                |||..|....|.:|   ||           ..|....|
Human   882 -LSTSVPNSYY----------------PDPFVPTAILVPIN---DE-----------THTMASDT 915

  Fly  1398 ALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEF 1462
            :.:|.....::|:|...|                              :|| |.: ||.|.:::.
Human   916 SSLVQSHTYKKREPADVP------------------------------YQT-GQL-HPAIRVADL 948

  Fly  1463 ANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVG 1527
            ..||.::|..:...|.:||||...||...||::..:.|:.||||.|:.|||||||:|..:||...
Human   949 LQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTN 1013

  Fly  1528 SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR 1592
            |||||.||.|||.:.|.|:|||||:|||..|||||.|...||:|:|:|.|.|..|:||.:|||. 
Human  1014 SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD- 1077

  Fly  1593 GTETYGQIFVTITETQELATYSIRTF-----------------QLCRQGFNDRREIKQLQFTAWP 1640
            .||.|..|.||:.||:.||.|.||||                 ::.::|.::.|||:|..||.||
Human  1078 DTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWP 1142

  Fly  1641 DHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHV 1705
            |||||.|....|.|:|:.::.:||.:||::||||||.|||||:||||.||:..:.|.::|||..|
Human  1143 DHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1207

  Fly  1706 TCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPA---RNLHTHLQKLLITEPGETISGMEVE 1767
            ..||::|..|||||:||:|||||||||.:||.|.|||   |:|:..:.||   :|....|.::.|
Human  1208 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKL---DPQTNSSQIKEE 1269

  Fly  1768 FKKLSNVK-----MDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDG 1827
            |:.|:.|.     .|.|   .|.||.|..|||.:.|||.:....:|..|.| |.|:|:||:.:|.
Human  1270 FRTLNMVTPTLRVEDCS---IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDS 1330

  Fly  1828 YRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRY---QYY 1889
            |:..||:|..|.|:.:..:||||::.:::.|.||||..:..  .:.|.||||.....|:   |..
Human  1331 YKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVE 1393

  Fly  1890 VVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWP-EQGVPKSGEGFIDFIGQVHKTKEQ 1953
            .|....|.::.....|.:.....:|| .|.|:||||:.|| .:..|.|...|:..|.||.|.:|:
Human  1394 FVSADLEEDIISRIFRIYNAARPQDG-YRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEE 1457

  Fly  1954 F-GQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCY 2017
            : |.:|...|||..|.||||.|..:|||.|.::::..:|||..|:.||:.:|.||...|||.|||
Human  1458 YNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1522

  Fly  2018 RAALEYLGS 2026
            ..|||||.|
Human  1523 EVALEYLNS 1531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020 3/8 (38%)
FN3 <382..747 CDD:442628 73/377 (19%)
FN3 712..810 CDD:238020 30/104 (29%)
FN3 832..898 CDD:214495 17/76 (22%)
FN3 <867..1269 CDD:442628 95/459 (21%)
fn3 914..998 CDD:394996 27/103 (26%)
R-PTPc-LAR-1 1498..1735 CDD:350401 133/253 (53%)
R-PTP-LAR-2 1784..2021 CDD:350402 92/241 (38%)
PTPRMXP_016881383.2 MAM 50..207 CDD:214533 37/209 (18%)
FN3 180..>663 CDD:442628 125/565 (22%)
ig 217..299 CDD:395002 17/92 (18%)
fn3 524..599 CDD:394996 23/81 (28%)
R-PTPc-M-1 947..1236 CDD:350481 145/289 (50%)
R-PTPc-M-2 1322..1527 CDD:350483 78/207 (38%)
Blue background indicates that the domain is not in the aligned region.

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