DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and PTPRK

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001278910.1 Gene:PTPRK / 5796 HGNCID:9674 Length:1462 Species:Homo sapiens


Alignment Length:1775 Identity:480/1775 - (27%)
Similarity:719/1775 - (40%) Gaps:502/1775 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 GDFSFGGTKMESAPRNVQVRT--------LSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEA 468
            |.||.||...:..|.......        :..|.....:.|||.|.|.      |...:|:..:.
Human    29 GQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGS------YMIVDSSDHDP 87

  Fly   469 SWNSQMVDNSELTTVSELTPHAI---YTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQP----SNF 526
            ...:::    :|.|:.|...|.|   |.:    |:..|..|.:..:.|:..:|..:.|    :.|
Human    88 GEKARL----QLPTMKENDTHCIDFSYLL----YSQKGLNPGTLNILVRVNKGPLANPIWNVTGF 144

  Fly   527 RATD--IGETAVTLQWTKPTHSSENIVHYELYWN-DTYANQAHHKRISNSEAYTLDGLYP--DTL 586
            ...|  ..|.||:..|..         .|::.:. :....::.:..|.:.:..:    ||  .:.
Human   145 TGRDWLRAELAVSTFWPN---------EYQVIFEAEVSGGRSGYIAIDDIQVLS----YPCDKSP 196

  Fly   587 YYIWLA-ARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTI-SLSWLPPPVERSNG----- 644
            :::.|. .....|:.||                 ...|||....: :..||    :|.||     
Human   197 HFLRLGDVEVNAGQNAT-----------------FQCIATGRDAVHNKLWL----QRRNGEDIPV 240

  Fly   645 ---RIIYYKVF-----FVEVGRED---------DEATTMTLNMTSIVLDELKR-----------W 681
               :.|.::.|     ..||.:.|         .|..:...|...:::.|..|           .
Human   241 AQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGP 305

  Fly   682 TEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRG 746
            |...|.:.|.:.:|||    ||||:..|             ...||  .||.             
Human   306 TYLLIQLNANSIIGDG----PIILKEVE-------------YRMTS--GSWT------------- 338

  Fly   747 YHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDR---SAAIVV 808
             ..||          :|.|         .:.:..|.|||:|.|:| .|||.|:|..   ...::.
Human   339 -ETHA----------VNAP---------TYKLWHLDPDTEYEIRV-LLTRPGEGGTGLPGPPLIT 382

  Fly   809 KTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTK 873
            :|....|:|...:|||.|.: ...|.::||.        .||                       
Human   383 RTKCAEPMRTPKTLKIAEIQ-ARRIAVDWES--------LGY----------------------- 415

  Fly   874 KRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTR 938
                |:.|.  :.|.|....|...|....|                        ..|:..||...
Human   416 ----NITRC--HTFNVTICYHYFRGHNESK------------------------ADCLDMDPKAP 450

  Fly   939 EHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIV 1003
            :|              .::| |....|::| |.:.||.|...|                |::.|:
Human   451 QH--------------VVNH-LPPYTNVSL-KMILTNPEGRKE----------------SEETII 483

  Fly  1004 ETERDM-GRAPM-SLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTE 1066
            :|:.|: |..|: |||..:...:....|.||:...|.:..|:|.|  :::...|.          
Human   484 QTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISY--SSIRSFDP---------- 536

  Fly  1067 SADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRL 1131
                         ||.:|.                  |.....||             |:.    
Human   537 -------------AVPVAG------------------PPQTVSNL-------------WNS---- 553

  Fly  1132 TPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYN--VNVSAIPSDY 1194
                                              .|:|..|    |.|.|||.  :..|.:.   
Human   554 ----------------------------------THHVFMH----LHPGTTYQFFIRASTVK--- 577

  Fly  1195 SYRPPTKITVTTQMAAPQPMVKPDFYGV-----VNGEEILVILPQASEEYGPISHYYLVVVPEDK 1254
            .:.|.|.|.|||.::||   ..||:.||     .....|.|:|..|..:..|||.|.:||     
Human   578 GFGPATAINVTTNISAP---TLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVV----- 634

  Fly  1255 SNLHKIPDQFLTDDLLPGRNKPE-----------------RPNAP-YIAAKFPQRSI--PFTFHL 1299
                        ::|.|.|.|.|                 ...|| |.||:.|..::  |..|.:
Human   635 ------------EELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687

  Fly  1300 GSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNW 1364
            |....|..|.|..|...|.|.|:.:|:          ||...|..:..:|.|.......      
Human   688 GDNRTYQGFWNPPLAPRKGYNIYFQAM----------SSVEKETKTQCVRIATKAAATE------ 736

  Fly  1365 PAEPEVSVNRNKDEPEILWVV-LPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAAD 1428
              ||||..:..|....::.:. :...:..||: ..|:|:.:||:.:...|..|....||..|...
Human   737 --EPEVIPDPAKQTDRVVKIAGISAGILVFIL-LLLVVILIVKKSKLAKKRKDAMGNTRQEMTHM 798

  Fly  1429 LGA---------------------------GP-TPSDP------------------------VDM 1441
            :.|                           .| .|:||                        :|:
Human   799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDV 863

  Fly  1442 RRL-------NFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEH 1499
            .|.       .:|| |.: ||.|.:::...||..:|::|:..|.:||||...||..:||.:..:.
Human   864 PRYLCEGTESPYQT-GQL-HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQ 926

  Fly  1500 NKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYC------DGYRKHNAYVATQGPLQETFVD 1558
            |::||||.|:.|||||||.|..||....||||||||.      |||::.:.|:|||||:.||..|
Human   927 NRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYD 991

  Fly  1559 FWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQ 1623
            ||||.|:.::|.|||:|.|.|..|:||.:|||. .||.||...||..|.:.||.|.:|||.|.|:
Human   992 FWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERR 1055

  Fly  1624 GFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDS 1688
            |:|:.||:||..||.|||||||.|....|.|:||.:...||.:||::||||||.||||||||||.
Human  1056 GYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI 1120

  Fly  1689 MLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLL 1753
            ||:..:.|.::|||..|..||::|..|||||:||||||||||||.:||.|.:|..........::
Human  1121 MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMI 1185

  Fly  1754 ITEPGETISGMEVEFKKLSNV--KMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEG 1816
            ..:.....|.::.||:.|::|  ::.:.....|.||.|..|||.:.:||.:....:|..|.| |.
Human  1186 RIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ES 1249

  Fly  1817 SDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHE 1881
            |:|:||:.:|.||..:|:|..|.|:.:..:||||:::::..|.:|||.::..  .:.|.||||.|
Human  1250 SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEE 1312

  Fly  1882 RSVRYQYYVVDPIA---EYNMPQYKLREFKVTDARDGSSRTVRQFQFIDW-PEQGVPKSGEGFID 1942
            ..:||....|:.::   :.::.....|...:|..::| ...|:|||::.| ..:.||.|...|:.
Human  1313 GMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEG-YLMVQQFQYLGWASHREVPGSKRSFLK 1376

  Fly  1943 FIGQVHKTKEQFGQ-DGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAM 2006
            .|.||.|.:|:..: :|...:||..|.||||:|..:.||:|.::.:.|:|||..|:.||:.:|.|
Human  1377 LILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNM 1441

  Fly  2007 VQTEDQYHFCYRAALEYLGS 2026
            |:..:||.|||..|||||.|
Human  1442 VEAPEQYRFCYDVALEYLES 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020 18/101 (18%)
FN3 520..610 CDD:238020 15/99 (15%)
FN3 616..707 CDD:238020 27/124 (22%)
FN3 712..810 CDD:238020 20/100 (20%)
FN3 832..907 CDD:238020 12/74 (16%)
FN3 914..1005 CDD:238020 15/90 (17%)
FN3 1012..1101 CDD:238020 15/89 (17%)
fn3 1106..1198 CDD:278470 12/93 (13%)
PTPc 1476..1731 CDD:214550 142/260 (55%)
PTPc 1503..1731 CDD:238006 132/233 (57%)
PTPc 1763..2022 CDD:214550 90/265 (34%)
PTPc 1791..2022 CDD:238006 82/235 (35%)
PTPRKNP_001278910.1 MAM 32..192 CDD:214533 33/186 (18%)
IG_like 202..288 CDD:214653 18/106 (17%)
fn3 297..371 CDD:365830 30/126 (24%)
fn3 488..581 CDD:365830 30/193 (16%)
PTP_DSP_cys 888..1166 CDD:391942 149/278 (54%)
Substrate binding. /evidence=ECO:0000250 1105..1111 4/5 (80%)
R-PTPc-K-2 1252..1457 CDD:350484 72/207 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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