DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and PTPRF

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_005271136.1	Gene:	PTPRF / 5792	HGNCID:	9670	Length:	1922	Species:	Homo sapiens

Alignment Length:	2084	Identity:	962/2084 - (46%)
Similarity:	1260/2084 - (60%)	Gaps:	248/2084 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGT 79
            :|::|.|:...|     ....|..|:.|::|....||||||.|.|.|:|.|.|.|.|.|||||
Human    17 ALVMLGLVAGAH-----GDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVS-- 74

  Fly    80 QSRYTVLE-QPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVIT 143
            ..|:.|:| ..|..|:|||:|:|..||:|.|||.|.|.:|: ::..|.|::.|.::.|.|||.|.
Human    75 SQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGE-INTSAKLSVLEEEQLPPGFPSID 138

  Fly   144 QGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVD--MSNPRY-SLKDGFLQIENSREEDQG 205
            .||..:|:|...|..|.|.|.|||.|.|.|.|:...||  .||.|. .|:.|.||||:|.|.|||
Human   139 MGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQG 203

  Fly   206 KYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHV 266
            ||||||.||.||.:|...||||:    ||||.|.||.||.: .|||.|.::||:|:|||:|||:|
Human   204 KYECVATNSAGTRYSAPANLYVRDQREVRRVAPRFSIPPSS-QEVMPGGSVNLTCVAVGAPMPYV 267

  Fly   267 KWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQIS 331
            |||.|:|:||.|:|||:|||||:|.|:..||||||:|.|:||.|::.:.|.|::||..|.|:.::
Human   268 KWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVT 332

  Fly   332 EVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVN 396
            |.|||||.|.|.....|.:.||.|||:.......|.|:.|:.|..|.:..|||::||.|.|:|||
Human   333 ETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN 397

  Fly   397 NIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTT 461
            :|||||||......||:     ....|.||.||.|.||:|||::.|||||.|||.|.||:||||.
Human   398 SIGRGPPSEAVRARTGE-----QAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP 457

  Fly   462 NSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNF 526
            :|.:|..:|:....|...||||..|.|...|::||.|:|::|.||.|..:|||.|||||:||::|
Human   458 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 522

  Fly   527 RATDIGETAVTLQWTKPTHSSENIVHYEL-YWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIW 590
            :|....:|.:.|.|..|  ..|.|:.||| ||.....:|.|......:.:|||:.|.|||||...
Human   523 QAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQ 585

  Fly   591 LAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFF 653
            |||||..|.|..||.|..||.|.  .|||:.:..::..|||:.:||:|||.:..||.|..|.|.:
Human   586 LAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 650

  Fly   654 VEVGRED---DEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVP-GD 714
            ..|..||   .....::...:|..|..|::||||::||.|.|.||.||.|.|:::||.|||| |.
Human   651 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGP 715

  Fly   715 PQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD-EGKGFLNEPFKFDVV------- 771
            |:.|:..|||||::||.||.|:...::|.||||.:....|.: |.:|.   |...||:
Human   716 PRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL---PIIQDVMLAEAQWR 777

  Fly   772 ----DTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVS 832
                :..|..::||.|:|.||:.|||.|.||||.||...:|.|.|.||.|||:.:........:
Human   778 PEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL- 841

  Fly   833 IELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGI 897
              |:|..|.:..|||.||||::...|:|....:..|..........|.:|..|.||:|..|..|:
Human   842 --LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 904

  Fly   898 GQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGS 962
            |:|..|..:|||..|.|.|.|:.:...|.....:.||||....|||.|..|.|.|     ..:.|
Human   905 GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF-----RDINS 964

  Fly   963 ERNM----TLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVET---ERDMGRAPMSLQAEA 1020
            ::.:    |..:...|.|:.:|.|..:|||:|.:|:||.|..:...|   |:...:   :.:..|
Human   965 QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK---NFRVAA 1026

  Fly  1021 TSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAA 1085
            ..:.:..:.||...|....:.:||.|...:|| :|....:.:       :.:|:...:|:..:..
Human  1027 AMKTSVLLSWEVPDSYKSAVPFKILYNGQSVE-VDGHSMRKL-------IADLQPNTEYSFVLMN 1083

  Fly  1086 RFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQ 1150
            | .:..|.|...|::|..|:
Human  1084 R-GSSAGGLQHLVSIRTAPD--------------------------------------------- 1102

  Fly  1151 GFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMV 1215
                  ::|.:.:....|::....:...|..
Human  1103 ------LLPHKPLPASAYIEDGRFDLSMPHV---------------------------------- 1127

  Fly  1216 KPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDK------SNLHKIPDQFLTDDLLPG-- 1272
                                 ::...:..:|:||||.|:      :.....|::...|:||..
Human  1128 ---------------------QDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIE 1171

  Fly  1273 ---------RNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVD 1328
                     |.:.||.. ||:||:..  .:|.||.||...:|..|.||.|..:..|:.||.|.:.
Human  1172 QGGEEQRRRRRQAERLK-PYVAAQLD--VLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLK 1233

  Fly  1329 TP--QKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVS 1391
            .|  ||. |.|||:|:.:.:                      :|:..:.::|||:|||..|::..
Human  1234 EPMDQKR-YASSPYSDEIVV----------------------QVTPAQQQEEPEMLWVTGPVLAV 1275

  Fly  1392 TFIVSTALIVLCVV----KRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPG-- 1450
            ..|:   |||:.::    ||...|....:|:...:..:.|.      .||||:|||||:||||
Human  1276 ILII---LIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAH------SSDPVEMRRLNYQTPGSS 1331

  Fly  1451 ---------MISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRY 1506
                     |..||||||::.|::|||||:||..|||||||||:|||||||:|||||.||.||||
Human  1332 VPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRY 1396

  Fly  1507 ANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATI 1571
            |||.|||||||.|.:::||.|||||||||.|||||.|||:||||||.||..|||||.||.:|||:
Human  1397 ANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1461

  Fly  1572 VMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQF 1636
            ||||||||::|:|||||||.|||||.|.|.||:.:|.|||||::|||.|.:.|.:::||::|.||
Human  1462 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF 1526

  Fly  1637 TAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDI 1701
            .||||||||::|.|.|.||||.:|..|.::||::||||||||||||:||||:|||||||||.:||
Human  1527 MAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDI 1591

  Fly  1702 YGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEV 1766
            ||||||:|:||||||||||||:|||:|:|||..||.||||||||:.|:|||....|||:::.||:
Human  1592 YGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMEL 1656

  Fly  1767 EFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYR 1831
            |||.|::.|..:|:|::|||||||.|||||:|:|||.:||.|.||.|:|||||:||||:||||.:
Human  1657 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQ 1721

  Fly  1832 SAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAE 1896
            .||||.|||:.::.||||||||||||||:||||||:|||||||.||||.|||.||||:||||:||
Human  1722 KAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE 1786

  Fly  1897 YNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIT 1961
            ||||||.||||||||||||.|||:|||||.|||||||||:|||||||||||||||||||||||||
Human  1787 YNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1851

  Fly  1962 VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026
            |||||||||:|||||||||||||:||||:|:||||:.||:||||||||||||..|||||||||||
Human  1852 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS 1916

  Fly  2027 FDNY 2030
            ||:|
Human  1917 FDHY 1920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	44/94 (47%)
		I-set	36..129	CDD:254352	44/93 (47%)
		IG_like	146..227	CDD:214653	43/83 (52%)
		Ig	159..228	CDD:299845	40/71 (56%)
		I-set	234..318	CDD:254352	49/83 (59%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	40/67 (60%)
		fn3	324..404	CDD:278470	36/79 (46%)
		FN3	423..514	CDD:238020	46/90 (51%)
		FN3	520..610	CDD:238020	37/90 (41%)
		FN3	616..707	CDD:238020	35/93 (38%)
		FN3	712..810	CDD:238020	43/110 (39%)
		FN3	832..907	CDD:238020	24/74 (32%)
		FN3	914..1005	CDD:238020	29/94 (31%)
		FN3	1012..1101	CDD:238020	16/88 (18%)
		fn3	1106..1198	CDD:278470	3/91 (3%)
		PTPc	1476..1731	CDD:214550	185/254 (73%)
		PTPc	1503..1731	CDD:238006	162/227 (71%)
		PTPc	1763..2022	CDD:214550	205/258 (79%)
		PTPc	1791..2022	CDD:238006	189/230 (82%)
PTPRF	XP_005271136.1	I-set	33..124	CDD:254352	44/93 (47%)
		Ig	50..121	CDD:143165	35/73 (48%)
		I-set	135..225	CDD:254352	46/89 (52%)
		Ig2_RPTP_IIa_LAR_like	152..226	CDD:143215	40/73 (55%)
		IG_like	242..319	CDD:214653	45/77 (58%)
		Ig3_RPTP_IIa_LAR_like	250..318	CDD:143216	40/67 (60%)
		FN3	323..412	CDD:238020	39/88 (44%)
		FN3	419..511	CDD:238020	47/91 (52%)
		FN3	516..605	CDD:238020	37/90 (41%)
		fn3	613..700	CDD:278470	33/86 (38%)
		FN3	714..820	CDD:238020	42/108 (39%)
		FN3	825..914	CDD:238020	28/91 (31%)
		FN3	923..1011	CDD:238020	28/92 (30%)
		FN3	1020..>1079	CDD:238020	12/69 (17%)
		PTPc	1366..1621	CDD:214550	185/254 (73%)
		PTPc	1392..1621	CDD:238006	162/228 (71%)
		PTPc	1657..1912	CDD:214550	203/254 (80%)
		PTPc	1682..1912	CDD:238006	189/229 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	419	1.000	Domainoid score	I641
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1250	1.000	Inparanoid score	I177
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm41127
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860