DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and PTPRC

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_002829.3	Gene:	PTPRC / 5788	HGNCID:	9666	Length:	1306	Species:	Homo sapiens

Alignment Length:	1711	Identity:	403/1711 - (23%)
Similarity:	629/1711 - (36%)	Gaps:	555/1711 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 ITMYYVVRALS---PYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLS 434
            :|||..::.|:   .:.:.|.:|     .|:.|..:|...||       .||.|.|       ||
Human     1 MTMYLWLKLLAFGFAFLDTEVFV-----TGQSPTPSPTGLTT-------AKMPSVP-------LS 46

  Fly   435 SS---TMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRV 496
            |.   |....:.|..|...:   .....||.|..|         ||    |.::::|.::  ...
Human    47 SDPLPTHTTAFSPASTFERE---NDFSETTTSLSP---------DN----TSTQVSPDSL--DNA 93

  Fly   497 QAYTSMGAGPMSTP-VQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDT 560
            .|:.:.|...:.|| :...|....||     ..||                           ..|
Human    94 SAFNTTGVSSVQTPHLPTHADSQTPS-----AGTD---------------------------TQT 126

  Fly   561 YANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIAT 625
            ::..|.:.:::.:.........|           .:|...:|.|..||               :.
Human   127 FSGSAANAKLNPTPGSNAISDVP-----------GERSTASTFPTDPV---------------SP 165

  Fly   626 SSTTISL---SWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLD--ELKRWTEYK 685
            .:||:||   |....|...||                    ||:|.|.:...|:  |....:...
Human   166 LTTTLSLAHHSSAALPARTSN--------------------TTITANTSDAYLNASETTTLSPSG 210

  Fly   686 IWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIH 750
            ..|::.|::...| |.|.......::..|....|.|.|.:..::|:..   .:..|.......:|
Human   211 SAVISTTTIATTP-SKPTCDEKYANITVDYLYNKETKLFTAKLNVNEN---VECGNNTCTNNEVH 271

  Fly   751 AQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVP 815
                                      |:|..: :...||...:.|..   |::  :::..|.||.
Human   272 --------------------------NLTECK-NASVSISHNSCTAP---DKT--LILDVPPGVE 304

  Fly   816 VRPTVSLKIMEREPIVSIELEWERPAQTY---GELRGYRLRWGVKDQALKEEMLSGPQMTKKRFD 877
            .........:|:.. .:|.|:|:. .:|:   .:...||.:.|        .|:...:..|  .:
Human   305 KFQLHDCTQVEKAD-TTICLKWKN-IETFTCDTQNITYRFQCG--------NMIFDNKEIK--LE 357

  Fly   878 NLERGVEY--EFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREH 940
            |||...||  :..:..:||......  ||.:|..|:| |.|..|..|.:......:||:||.|
Human   358 NLEPEHEYKCDSEILYNNHKFTNAS--KIIKTDFGSP-GEPQIIFCRSEAAHQGVITWNPPQR-- 417

  Fly   941 RNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVET 1005
                      .||           |.||                   .|.|            ||
Human   418 ----------SFH-----------NFTL-------------------CYIK------------ET 430

  Fly  1006 ERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADL 1070
            |:|.    ::|..                   .|:.|                          ||
Human   431 EKDC----LNLDK-------------------NLIKY--------------------------DL 446

  Fly  1071 VNLEKFAQYAVAIAARF-----KNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIR 1130
            .||:.:.:|.:::.|..     :||...:....|....|..|                 |:..:.
Human   447 QNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQV-----------------WNMTVS 494

  Fly  1131 LTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYS 1195
            :|..|                              ..:||.
Human   495 MTSDN------------------------------SMHVKC------------------------ 505

  Fly  1196 YRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPED---KSNL 1257
             |||                                    .:..||...|:|.|...:   ::..
Human   506 -RPP------------------------------------RDRNGPHERYHLEVEAGNTLVRNES 533

  Fly  1258 HKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIF 1322
            ||..| |...||                    |.|..:||..    .:||
Human   534 HKNCD-FRVKDL--------------------QYSTDYTFKA----YFHN--------------- 558

  Fly  1323 VRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLP 1387
                                                   .::|.||.:..:......:.|...|.
Human   559 ---------------------------------------GDYPGEPFILHHSTSYNSKALIAFLA 584

  Fly  1388 LMVSTFIVSTALIVLCVVKR-----RRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQ 1447
            .:    |:.|::.:|.|:.:     :::.|...:|    :.|:..|           |.::|...
Human   585 FL----IIVTSIALLVVLYKIYDLHKKRSCNLDEQ----QELVERD-----------DEKQLMNV 630

  Fly  1448 TPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTA 1511
            .|   .|..|.:..:...|    :::.:.|..|::|| ....:|....:....|::||||.::..
Human   631 EP---IHADILLETYKRKI----ADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 688

  Fly  1512 YDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTR 1576
            ||::||:|..:.|..||:||||:|.||:::...|:|.|||..||..|||||.||.|...|||:||
Human   689 YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 753

  Fly  1577 LEERTRIKCDQYWPT--RGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDR---REIKQLQF 1636
            .||..|.||.:|||:  .||..:|.:.|.|.:.:....|.|:...:..:  .::   ||:..:||
Human   754 CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK--KEKATGREVTHIQF 816

  Fly  1637 TAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDI 1701
            |:|||||||:.|...|:..||..|.:...|||::|||||||||||.||.||:|||.::.|..:|:
Human   817 TSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDV 881

  Fly  1702 YGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEV 1766
            ||:|..||.||..|||.|.|||.||.|::|....|.|||....||.:|..:...:|....|.:|.
Human   882 YGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEA 946

  Fly  1767 EFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGI----------------- 1814
            ||::|.:.:...::.: .|...||.|||..:::||:.:||.|.  |.:
Human   947 EFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLK--HELEMSKESEHDSDESSDDD 1008

  Fly  1815 ----EGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCF 1875
                |.|.|:|||||..|......||||||:::...|||:|:::....::||||:||...:|.|.
Human  1009 SDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICA 1073

  Fly  1876 QYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGF 1940
            ||| .|....|....||.........|.||.|::..::...||||.|:|:.:|..:.:|...:..
Human  1074 QYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKEL 1137

  Fly  1941 IDFIGQVHKTK--EQFGQDG-------PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTV 1996
            |..| ||.|.|  ::...:|       |:.:||..|..::|:|..|..:||..:.|.|:|:||.|
Human  1138 ISMI-QVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVV 1201

  Fly  1997 RILRSQRPAMVQTEDQYHFCY 2017
            :.||..||.||.|.:||.|.|
Human  1202 KALRKARPGMVSTFEQYQFLY 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470	8/33 (24%)
		FN3	423..514	CDD:238020	20/94 (21%)
		FN3	520..610	CDD:238020	12/89 (13%)
		FN3	616..707	CDD:238020	19/95 (20%)
		FN3	712..810	CDD:238020	13/97 (13%)
		FN3	832..907	CDD:238020	18/79 (23%)
		FN3	914..1005	CDD:238020	16/90 (18%)
		FN3	1012..1101	CDD:238020	12/93 (13%)
		fn3	1106..1198	CDD:278470	6/91 (7%)
		PTPc	1476..1731	CDD:214550	117/260 (45%)
		PTPc	1503..1731	CDD:238006	111/232 (48%)
		PTPc	1763..2022	CDD:214550	95/285 (33%)
		PTPc	1791..2022	CDD:238006	88/257 (34%)
PTPRC	NP_002829.3	PTP_N	7..32	CDD:372119	5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..163		37/209 (18%)
		PHA03255	81..>231	CDD:165513	38/230 (17%)
		CD45	237..295	CDD:372194	13/92 (14%)
		FN3	392..462	CDD:238020	29/173 (17%)
		FN3	485..565	CDD:238020	28/266 (11%)
		R-PTPc-C-1	707..907	CDD:350405	97/201 (48%)
		Substrate binding. /evidence=ECO:0000250	853..859		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1014		0/20 (0%)
		R-PTP-C-2	1017..1223	CDD:350406	77/208 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810