DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and PTPRB

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_006719591.1 Gene:PTPRB / 5787 HGNCID:9665 Length:2230 Species:Homo sapiens


Alignment Length:1857 Identity:409/1857 - (22%)
Similarity:689/1857 - (37%) Gaps:550/1857 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   196 IENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVG 260
            ::|| |..||:...:|...:..:|:..|:|.:        ..:.|....|..:.|..:...:.: 
Human   673 LKNS-ERCQGRTVPLAVLQLRVKHANETSLSI--------MWQTPVAEWEKYIISLADRDLLLI- 727

  Fly   261 SPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAP 325
                |....|.:::.|..:.:| ||            .|.....|..|.:.:.|.||.:::|...
Human   728 ----HKSLSKDAKEFTFTDLVP-GR------------KYMATVTSISGDLKNSSSVKGRTVPAQV 775

  Fly   326 TDVQISEVTAT-SVRLEWSYKGPEDLQYYVIQYKPKNA---NQAFSEISGIITMYYVVRALSPYT 386
            ||:.::....| |:...|: :...|:::|.:....:|.   |::.|.    .|..|...:|...:
Human   776 TDLHVANQGMTSSLFTNWT-QAQGDVEFYQVLLIHENVVIKNESISS----ETSRYSFHSLKSGS 835

  Fly   387 EYEFYVIAVNN---------IGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITW 442
            .|...|..|:.         .||..||          |..|..:.::.||        ..:.::|
Human   836 LYSVVVTTVSGGISSRQVVVEGRTVPS----------SVSGVTVNNSGRN--------DYLSVSW 882

  Fly   443 --EPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMG-- 503
              .|     |.|..|:|   |.|:..:...:..:..:....:.|.|||..:|||.:.  |..|  
Human   883 LLAP-----GDVDNYEV---TLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTIT--TRSGKY 937

  Fly   504 -----AGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYAN 563
                 :...:.|.:|   |||  ..||...:|.    :.:.|   .|::.:..|||:    |..|
Human   938 ENHSFSQERTVPDKV---QGV--SVSNSARSDY----LRVSW---VHATGDFDHYEV----TIKN 986

  Fly   564 QAHH---KRISNSE-AYTLDGLYPDTLYYIWLAARS------QRGEGATTPPIPVRTKQYGAPPR 618
            :.:.   |.|..|| ......|.|..||.:.:..:|      ::|.|.|.|          .|.:
Human   987 KNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIP----------EPVK 1041

  Fly   619 NITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRW-- 681
            ::|....|:..:.::|     ..:||.:..|::                    .::.:::|.:  
Human  1042 DLTLRNRSTEDLHVTW-----SGANGDVDQYEI--------------------QLLFNDMKVFPP 1081

  Fly   682 -------TEYKIWVLAGTSVGDGPRSHPIILRTQED-----------VPGDPQDVKATPLNST-S 727
                   |||:.     ||:..|.:...::|....|           ||...:::..:|..:| |
Human  1082 FHLVNTATEYRF-----TSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDS 1141

  Fly   728 IHVSWKPPLEKDRNGIIRGYHI----HAQELRDE--GKGFLNEPF-------------------- 766
            :.|:|.|     ..|.:..|.:    |:|::..:  .|......|                    
Human  1142 LTVNWTP-----GGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSL 1201

  Fly   767 --KFDVVD-TLEFNVTGLQPD---TKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIM 825
              :.:||. |:..:|.|:..|   :.||:.|:.....|..:| ..|::.|..|:.:|.|      
Human  1202 KNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER-YDILLLTENGILLRNT------ 1259

  Fly   826 EREPIVSIELEWE---------------------RPAQTYG---------------ELRGYRLRW 854
             .||..:.:.::|                     :.|||.|               ..|....||
Human  1260 -SEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRW 1323

  Fly   855 GVK--------------DQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIG-IGQETVKI 904
            ...              |..|:|.....|.:....|.||.:|..|:..:.  .|.| :..|:...
Human  1324 TASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIV--THSGELSNESFIF 1386

  Fly   905 FQTPEGTPGGPPSNIT----IRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKI---DHGLGS 962
            .:|       .|::::    ....|.|.|...|.|.:.          |..|::.|   .:|...
Human  1387 GRT-------VPASVSHLRGSNRNTTDSLWFNWSPASG----------DFDFYELILYNPNGTKK 1434

  Fly   963 E--RNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQT 1025
            |  ::..|.:..|..|....:|:..|..:    :|..|:|:..|:.  ...:|.||.:.|....|
Human  1435 ENWKDKDLTEWRFQGLVPGRKYVLWVVTH----SGDLSNKVTAESR--TAPSPPSLMSFADIANT 1493

  Fly  1026 A-----------------EIWWEP---VT---------SRGKLL-----GYKIFYTMTAVEDLDD 1056
            :                 |:.|.|   :|         |.|:::     |....:.:..|.. |.
Human  1494 SLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSG-DS 1557

  Fly  1057 WQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSM 1121
            |:|                   |:..|..             :||.||:.:. ||.....::.::
Human  1558 WKT-------------------YSKPIFG-------------SVRTKPDKIQ-NLHCRPQNSTAI 1589

  Fly  1122 TLSWSPPIRLTPVNYKISFDAMKV---FVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTY 1183
            ..||.||        ...||...:   .:|:|....::.:.|.:.:|       .|..|.|...|
Human  1590 ACSWIPP--------DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLL-------NIMMLVPHKRY 1639

  Fly  1184 NVNV--------SAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQA----- 1235
            .|::        |.:..|      :.||:..:...|.|.::      ||.:::|:.....     
Human  1640 LVSIKVQSAGMTSEVVED------STITMIDRPPPPPPHIR------VNEKDVLISKSSINFTVN 1692

  Fly  1236 ----SEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKP------ERPNAP-------Y 1283
                |:..|.:.::.:||...|.|           |:|.|.:..|      .|.||.       |
Human  1693 CSWFSDTNGAVKYFTVVVREADGS-----------DELKPEQQHPLPSYLEYRHNASIRVYQTNY 1746

  Fly  1284 IAAKFPQ----RSIPFTFHLGS---------GDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHL- 1334
            .|:|..:    .|..|...||:         ......|.:..|:....|||.:||......:.| 
Human  1747 FASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLK 1811

  Fly  1335 -YTSSPFSE-FLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVST 1397
             :|...:|: |.||.:..        ..:|.:.|...||..              |.:...:|:.
Human  1812 EFTKPLYSDTFFSLPITT--------ESEPLFGAIEGVSAG--------------LFLIGMLVAV 1854

  Fly  1398 ALIVLCVVK----RRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRR-------LNF-QTPG 1450
            ..:::|..|    |.|                         ||..:.:||       ||. |...
Human  1855 VALLICRQKVSHGRER-------------------------PSARLSIRRDRPLSVHLNLGQKGN 1894

  Fly  1451 MISHPPIPISEFANHIERLKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTAYDH 1514
            ..:..||.|::|..|..:|:::.|...|:|||.: :.|:..:.|.:.|..|:.||||.|:..||.
Human  1895 RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDA 1959

  Fly  1515 SRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEE 1579
            :||:|..|:....||||||:|..|......|:.|||||..|..|||:|.||.....|||:|:..|
Human  1960 TRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVE 2024

  Fly  1580 RTRIKCDQYWPT-RGTETYGQIFVTITETQELATYSIRTFQLC-RQGFNDRREIKQLQFTAWPDH 1642
            :.|:|||.|||. :.:..||.:.:.:.....|..::||.|::| .:..:..|.|:...:|.||||
Human  2025 KGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDH 2089

  Fly  1643 GVPDHPAPFLQFLRRCRAL--TPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHV 1705
            |||:.....:||:|..|..  ..|.:||.:|||||||||||.:|.:|.:|:::..:..:||||.|
Human  2090 GVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAV 2154

  Fly  1706 TCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKK 1770
            ..||..|.:|||||.||:::|..:.:.:       .||.|.:..:..|              |..
Human  2155 HDLRLHRVHMVQTECQYVYLHQCVRDVL-------RARKLRSEQENPL--------------FPI 2198

  Fly  1771 LSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVY 1807
            ..||.           |.......|:|:||..||..|
Human  2199 YENVN-----------PEYHRGGHLLHLLPQVSSSRY 2224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653 9/30 (30%)
Ig 159..228 CDD:299845 9/31 (29%)
I-set 234..318 CDD:254352 14/83 (17%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 11/67 (16%)
fn3 324..404 CDD:278470 18/92 (20%)
FN3 423..514 CDD:238020 20/99 (20%)
FN3 520..610 CDD:238020 23/99 (23%)
FN3 616..707 CDD:238020 15/99 (15%)
FN3 712..810 CDD:238020 25/130 (19%)
FN3 832..907 CDD:238020 20/125 (16%)
FN3 914..1005 CDD:238020 19/99 (19%)
FN3 1012..1101 CDD:238020 18/122 (15%)
fn3 1106..1198 CDD:278470 19/102 (19%)
PTPc 1476..1731 CDD:214550 106/259 (41%)
PTPc 1503..1731 CDD:238006 98/231 (42%)
PTPc 1763..2022 CDD:214550 11/45 (24%)
PTPc 1791..2022 CDD:238006 7/17 (41%)
PTPRBXP_006719591.1 RICIN <22..94 CDD:238092
fn3 255..319 CDD:278470
fn3 331..407 CDD:278470
fn3 422..488 CDD:278470
FN3 507..582 CDD:238020
fn3 596..672 CDD:278470
fn3 687..765 CDD:278470 16/103 (16%)
fn3 774..847 CDD:278470 16/77 (21%)
fn3 862..938 CDD:278470 22/103 (21%)
fn3 950..1026 CDD:278470 23/91 (25%)
fn3 1039..1112 CDD:278470 15/102 (15%)
fn3 1126..1199 CDD:278470 12/77 (16%)
fn3 1216..1294 CDD:278470 16/85 (19%)
fn3 1305..1378 CDD:278470 13/74 (18%)
fn3 1394..1466 CDD:278470 15/85 (18%)
fn3 1480..1562 CDD:278470 16/101 (16%)
fn3 1574..1649 CDD:278470 17/90 (19%)
PTPc 1920..2178 CDD:214550 106/257 (41%)
PTPc 1947..2178 CDD:238006 98/230 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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