Protein Alignment Lar and PTPN12

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: XP_047276629.1
• Gene: PTPN12 / 5782
• HGNCID: 9645
• Length: 807
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 111/322 - (34%)
• Similarity: 153/322 - (47%)
• Gaps: 41/322 - (12%)

  Fly  1460 SEFANHIER-LKSNDN-----QKFSQEY--ESIEP---GQQFTWDNSNLEHNKSKNRYANVTAYD 1513
            |...|.:.. ||:|..     ::.|.:|  |.|.|   |::        |.|..||||.::..:|
Human    42 SSLGNRVRSCLKTNKQSAVRLRRLSTKYRTEKIYPTATGEK--------EENVKKNRYKDILPFD 98

  Fly  1514 HSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLE 1578
            ||||:|........|||||||:..|.....|||||||||..|.:|||||.||.....|||..|..
Human    99 HSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREF 163

  Fly  1579 ERTRIKCDQYWPTRGTE--TYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPD 1641
            |..|.||::|||..|.:  |:....::..:.|....|.|||..|..|  |:.|.:.|..:..|||
Human   164 EMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPD 226

  Fly  1642 HGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKI---IDIYG 1703
            |.||......|..:...|.....|..|:.:|||||.||||....||.....:|..||   .:::.
Human   227 HDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFN 291

  Fly  1704 HVTCLRAQRNYMVQTEDQYIFIHDAI---------------LEAIICGVTEVPARNLHTHLQ 1750
            .:..:|.||:..|||::||..:|.||               .:.|..||.|:...|:.:.::
Human   292 LIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIE 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	96/256 (38%)
		R-PTP-LAR-2	1784..2021	CDD:350402
PTPN12	XP_047276629.1	PTP_DSP_cys	60..325	CDD:475123	101/274 (37%)