Protein Alignment Lar and PTPN9

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_002824.1
• Gene: PTPN9 / 5780
• HGNCID: 9661
• Length: 593
• Species: Homo sapiens
• Alignment Length: 250
• Identity: 102/250 - (40%)
• Similarity: 147/250 - (58%)
• Gaps: 13/250 - (5%)

  Fly  1787 PCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRM 1851
            |.|..|||...:...:.:||.||...|...:||:||||:|||:.::|||..|||:::...|||.|
Human   325 PGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLM 389

  Fly  1852 LWEHNSTIVVMLTKLKEMGREKCFQYWPHERS--VRYQYYVVDPIAEYNMPQYKLREFKVTDARD 1914
            :||....::||.|:.:|.||.||.||||.|:.  :|:.:..|..:...||..||....::.:..:
Human   390 VWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEE 454

  Fly  1915 GSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTK---------EQFGQ--DGPITVHCSAGV 1968
            ...|.|..|||:.||:.|||.|....|||:..|...:         ...||  :.||.||||||:
Human   455 RQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGI 519

  Fly  1969 GRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY 2023
            ||:|.|.:|.|.|.:::..|.|:|||||..:|:||...:||.:||:|||:|.||:
Human   520 GRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401
		R-PTP-LAR-2	1784..2021	CDD:350402	100/246 (41%)
PTPN9	NP_002824.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		CRAL_TRIO_N	20..68	CDD:215024
		SEC14	90..240	CDD:214706
		PTPc-N9	299..569	CDD:350391	98/243 (40%)