DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and PTPN2

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_047293651.1 Gene:PTPN2 / 5771 HGNCID:9650 Length:494 Species:Homo sapiens


Alignment Length:493 Identity:129/493 - (26%)
Similarity:198/493 - (40%) Gaps:124/493 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1361 DPNWPAEPEVSVNRNKDEPEIL-------W--VVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPD 1416
            :|...|..|.........|:::       |  .|||.:||.   |...::               
Human    14 NPPVSASQEAGTTHAHHHPQLIKKIFWQSWCLTVLPRLVSN---SYPQVI--------------- 60

  Fly  1417 QAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIER---LKSNDNQKFS 1478
                        |.|||..:..:..........|.:...|.|.....|...|   :::.:.:..|
Human    61 ------------LPAGPPKAPGLQECAFYLAVTGWLLPVPTPHPRQQNLCSRQAAVRTKEIRNES 113

  Fly  1479 QEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHN 1543
            .:|    |.:.     :....|:::|||.:|:.||||||:|...|    :|||||:..|......
Human   114 HDY----PHRV-----AKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQR 165

  Fly  1544 AYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIF------V 1602
            :|:.|||||..|...||.|.|:.||..:||:.|:.|:..:||.|||||...|   .:|      |
Human   166 SYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQE---MLFKETGFSV 227

  Fly  1603 TITETQELATYSIRTFQLCRQGFN-------------------------DRREIKQLQFTAWPDH 1642
            .:......:.|::...||  :..|                         :.|.|....:|.|||.
Human   228 KLLSEDVKSYYTVHLLQL--ENINYIENLWITLYLKLLMLDVKRSLKSGETRTISHFHYTTWPDF 290

  Fly  1643 GVPDHPAPFLQFLRRCR--ALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHV 1705
            |||:.||.||.||.:.|  ....|:.||.::|||||:||:|.:.::|:.|..|:....|:|...:
Human   291 GVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVL 355

  Fly  1706 TCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKK 1770
            ..:|..|..::||.||..|.:.||:|...|                    ..|:  |.::..:|:
Human   356 LNMRKYRMGLIQTPDQLRFSYMAIIEGAKC--------------------IKGD--SSIQKRWKE 398

  Fly  1771 LSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYL 1808
            ||  |.|.|       |...|....:....|..:|:.|
Human   399 LS--KEDLS-------PAFDHSPNKIMTEKYNGNRIGL 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628
FN3 712..810 CDD:238020
FN3 832..898 CDD:214495
FN3 <867..1269 CDD:442628
fn3 914..998 CDD:394996
R-PTPc-LAR-1 1498..1735 CDD:350401 92/269 (34%)
R-PTP-LAR-2 1784..2021 CDD:350402 5/25 (20%)
PTPN2XP_047293651.1 PTP_DSP_cys 108..379 CDD:475123 92/288 (32%)
Blue background indicates that the domain is not in the aligned region.

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