DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lar and PTGS1

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_000953.2	Gene:	PTGS1 / 5742	HGNCID:	9604	Length:	599	Species:	Homo sapiens

Alignment Length:	369	Identity:	68/369 - (18%)
Similarity:	124/369 - (33%)	Gaps:	134/369 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   784 DTKYSIQVAALTRKGDGD------RSAAIVVKTPGGVPVRPTV-----------------SLKIM 825
            |.|...||.      ||:      ..|.:::..|.|:|.:..:                 :|.:.
Human   248 DGKLKYQVL------DGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLR 306

  Fly   826 EREPIVSIELEWERPAQTYGE----------LRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLE 880
            |...:..: |:.|.|  |:|:          |.|..::..:::..   :.|||..:..|....|.
Human   307 EHNRVCDL-LKAEHP--TWGDEQLFQTTRLILIGETIKIVIEEYV---QQLSGYFLQLKFDPELL 365

  Fly   881 RGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQ--------TPDVLCVTWDPPT 937
            .||::::|                            :.|.:.|.        .||...|.....:
Human   366 FGVQFQYR----------------------------NRIAMEFNHLYHWHPLMPDSFKVGSQEYS 402

  Fly   938 REH---RNGIITRYDVQ-----FHKKIDHGLGSERNM----------TLRKAVFTNLEENTEY-- 982
            .|.   ...::..|.|:     |.::|...:|..|||          .:|::....|:...||
Human   403 YEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRK 467

  Fly   983 IFRVRAYT--------KQGAGPFSD----------------------KLIVETERDMGRAPMSLQ 1017
            .|.::.||        |:.|....:                      .:..|:..::| ||.||:
Human   468 RFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIG-APFSLK 531

  Fly  1018 AEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKT 1061
            ....:...:..:|:|.|..|: :|:.|..|.| ::.|....|||
Human   532 GLLGNPICSPEYWKPSTFGGE-VGFNIVKTAT-LKKLVCLNTKT 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020	7/31 (23%)
		FN3	832..907	CDD:238020	15/84 (18%)
		FN3	914..1005	CDD:238020	23/148 (16%)
		FN3	1012..1101	CDD:238020	16/50 (32%)
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
PTGS1	NP_000953.2	EGF_CA	32..69	CDD:238011
PTGS1	NP_000953.2	prostaglandin_endoperoxide_synthase	89..575	CDD:188648	68/369 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900