DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptpn20

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_002664234.3 Gene:ptpn20 / 571774 ZFINID:ZDB-GENE-090313-90 Length:2195 Species:Danio rerio


Alignment Length:2460 Identity:469/2460 - (19%)
Similarity:829/2460 - (33%) Gaps:808/2460 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TAARPIAALSLLVLSL---LTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYC---------A 58
            |.:..:|...::|.||   |.|:    ||       ...||||.:::..  |..|         |
Zfish    86 TVSTKLAMEKIIVYSLGMTLYWS----VD-------YHLPQNQPIQLSD--SLNCLLLSMCEDMA 137

  Fly    59 ARGDPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSA 123
            .|.....||:      :|..:..:.::|..|..:....:|.|.  ::......:.||.|..:..:
Zfish   138 HRRTNLNSIL------EVCESHHKASLLPPPNKVIKQLVEDVL--QESVDRAALTENVVQLSGKS 194

  Fly   124 DATLTIYEGDKTP-AGFPVITQGPG-TRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPR 186
            ........|.:.| :|:..:....| ||.:.:.          ..|...|:   :..|.      
Zfish   195 QMIRERLHGKRGPYSGYTEMNGAAGETRRLSLD----------SEPKQGIF---HHQKT------ 240

  Fly   187 YSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVR--------RVPPTFSRPPETI 243
            :|||        ||......|:..:.|.:|..:.::|:.:.:..        .|.|  |.|..|:
Zfish   241 WSLK--------SRPSQTTSYQSSSRNPLGLHNRRSTSFWSRSSCLNSPNKGEVRP--SSPCITV 295

  Fly   244 SEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPE----NEMPIGRNVLQL-------------- 290
            ||    |.::||             .:.::.|.||    |:.|  :.:|:|              
Zfish   296 SE----SAVSLS-------------QRKAKSLGPEFTRMNDEP--QIILELPGSIVSKKGKSGLS 341

  Fly   291 ---INIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKG---PED 349
               :|: ...|..|:|...             .:.:...|| ...|.|.:..:|..|.|   .:|
Zfish   342 QREVNV-IMPNEQCVAVKC-------------DIKSRGRDV-FDMVVAHANLVEHFYFGLAFIDD 391

  Fly   350 LQYYVIQYKPKNANQA---FSEI-SGIITMYYVVR--------ALSPYTEYEFYV-----IAVNN 397
            .:::.:..:.|.:..|   :.:: |...|:|..||        .|..:|.:::|:     |..:.
Zfish   392 GEFFFLDPETKISKVAPDYWKKVASATFTLYLRVRFFPDDISYILHKHTRHQYYLQLRKDILEDR 456

  Fly   398 IGRGPPSA------PATCTTGDF-------SFGGTKM----------------ESAPR----NVQ 429
            :.....:|      ......||:       ::..|:.                |..||    |.|
Zfish   457 VHCNEETALFLAALALQAEFGDYMAEVYGKNYFQTEQYISKRVIEKVALPCLREELPRLHANNAQ 521

  Fly   430 VRTLSSST--MVITWEPPETPNGQVTGYKVYYTTNSNQP-----------------EASWNSQMV 475
            :....:.|  :.|..:.||      .|...:......:|                 |...||:|:
Zfish   522 MLPEEAETEFLKIAQQLPE------YGVLFHRVARERKPIIGELVLGICAKGILVYEVKNNSRML 580

  Fly   476 DN----SELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAV 536
            ..    :|..::|  |....:|:.                         ..||..:.:.:.|::.
Zfish   581 SRRFHWTETDSLS--TSRRKFTIE-------------------------CSPSGKKHSFVTESSK 618

  Fly   537 TLQWTKPTHSSENIVH---------YELYWNDTYAN-----QAHH---KRISNSEAYT----LDG 580
            ..|:.....|:::..|         |.|..:|:.|.     :|.|   ||:|.||...    |:|
Zfish   619 IAQYLLNLCSAQHKFHSEMTSRQLTYCLASDDSVAKYTSICRARHEQIKRLSCSEIVLNNIGLNG 683

  Fly   581 LYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYG---------AP--PRNITAIATSSTTISLSW 634
            |..|::         .:.....:..|.||.:|..         ||  |::     .|.::..|..
Zfish   684 LPSDSI---------SKSCDDLSAKIGVRIRQQNEVNYSPESRAPCEPKD-----QSQSSSPLET 734

  Fly   635 LPPPVER--SNGRIIYYKVFFVEVGREDDE--ATTMTLNMTS---------IVLDELKR------ 680
            ..|||.|  ||          |.:.::|.|  :||.::.:.:         |:...||:      
Zfish   735 FSPPVYRIMSN----------VSLQKQDSEVHSTTSSIRVDTPTKTTPEREIICVTLKKDPKLGY 789

  Fly   681 ---------WTEYKIWVLAGTSVGDGP-----RSHP----------------------------- 702
                     ..:..:.:...:.:.|||     |..|                             
Zfish   790 GFIIVGEDNTGKLDLGIFIASIIPDGPADKDGRIRPGGRLISLNNISLEGVTFNIAASILQNSPE 854

  Fly   703 ----IILRTQEDVPGDPQDVKATPL---------NSTSIHVSWKP---PLEKDRNGII-----RG 746
                |:.:.::|:.|....:..:.|         :.:::...::|   .||:..:.|:     :.
Zfish   855 EVELIVSQPKQDLRGSKTSLAPSNLGMMLERSFGSQSTLSAEYRPVMEELEETLSNIMAPKINKR 919

  Fly   747 YHI---HAQELRDE----GKGFLNEPFKFDVVDTLEFN-------------------------VT 779
            .||   ...:::||    ..||..:|.:...::..:.|                         :.
Zfish   920 MHIPVVRILDIQDEMSKSSSGFSLKPGEIIYMELRKINGSLGISVAGGINTNVHHGGIYIKSVIA 984

  Fly   780 GLQPDTKYSIQVAALTRKGDG-------DRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIE--- 834
            |...|....||:.....:.||       .|.|...:|..|.|     ||| ::||||.|.::   
Zfish   985 GGAADQDGRIQIGDRLLEVDGCNLRAVTHRQAVECLKRTGEV-----VSL-VLEREPPVVLDTSS 1043

  Fly   835 ----LEWER-------------PAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERG 882
                ||..|             |.||...:|....|: |.|:.:.|..|      :|.|.    |
Zfish  1044 ASSTLERRRSPSPLSAPLRRDVPLQTPLSVRTKDFRF-VSDENILEVTL------QKSFS----G 1097

  Fly   883 VEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITR 947
            :.:.|.|:     .:|.|...|.|....:.|.|..:..:..:...:|.|..:|.     .|:  .
Zfish  1098 LGFSFLVS-----ELGPEKENIVQIKSLSSGHPAGDCGLLKEGDIILAVNGEPV-----RGL--S 1150

  Fly   948 YDVQFHKKIDHGLGSERNMTLRKA-------VFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVET 1005
            |:...|  :.....||..:::.:.       :.|.|..|.|...|......:...|...:|::..
Zfish  1151 YEEVLH--LLQKSPSEIRLSICRPSQDEHTDIETFLVPNRELRSRSLDLQARSVAPDFSELLLRR 1213

  Fly  1006 ERDMGRAPMSLQAEATSEQTAE-------------IWWEPVTSRGKLLGYKIFYTMTAVEDLDDW 1057
            ..:||     |:.||:.|:|.|             :...|.::.|   |.:..:.:.    ::::
Zfish  1214 AIEMG-----LKKEASPEETQESELLETDKSIPPPLPPRPSSAEG---GERKPHVIL----VEEY 1266

  Fly  1058 QTK----------TVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEK------VTVRIKPED 1106
            :.|          |.|:.:::....::..|....||.|..:..|.....:      .|..:|.|.
Zfish  1267 EKKDPPPPPTPPPTPGILKASTTNTVQTPAAPKTAIKAHQQESLEPTVSRSNHVSACTSHVKDEG 1331

  Fly  1107 VPLNLRAHDVSTHSMTL------------------------------SWSPPIRLTPVNYKISFD 1141
            |..|:.:...:..::|.                              :.||.:..||..|:.:..
Zfish  1332 VEENVISFTANGLTVTAGEEYLTISTTAPSPPSGSTAVSSEAPPPVPALSPSLLNTPPTYQQAIQ 1396

  Fly  1142 AMK-----VFVDSQGF----SQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSY- 1196
            |..     ....:.|:    .:....|:|: :.|.:..|.::.: |...::...::....|..| 
Zfish  1397 AASPAEPPAQPSNNGWDDDDEEDDEDPRRD-VFKEFELTVSLTK-SWCGSFGFTITRSKLDNCYY 1459

  Fly  1197 -----RPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSN 1256
                 ..|.|  ...::.|...::      :|||..:..:....:          :.::......
Zfish  1460 VQDVLDNPAK--ADGRLRAGDRLI------MVNGHNVTSVTDDVA----------ISILRCSSKR 1506

  Fly  1257 LHKIPDQFLTDDLLPGRNKPERPNA--PYIAAKFP--QRSIPFTFHLGSGDDYHNFTNRKLEREK 1317
            ||.:..: ...:|||    |..|:.  ..|.:|.|  |..|..|..:||               |
Zfish  1507 LHMVLGR-AVQNLLP----PPPPDTLQDIIISKTPSGQLGIKLTGGIGS---------------K 1551

  Fly  1318 RYRIFVRAVVDTPQKHLYTSSPFSEFLSLD-----------------------MREAPP------ 1353
            |..|:|:.||        .|||.||..|:.                       :.|:.|      
Zfish  1552 RQGIYVQEVV--------LSSPASEEGSIQPNDKIVYICGRCTLGMTLEDAVKVCESSPRKVRFK 1608

  Fly  1354 ---GERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTP 1415
               .::|..|...|....|  ....|..|.:...:.|.:.|......|:....::.|:|......
Zfish  1609 AMRDDQPVIPRDKWNGLFE--WKEKKGFPHLEEPMSPDVHSALADVKAVADSAMLFRKRLSVTAE 1671

  Fly  1416 DQAAV-----TRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEF-----ANHIERLK 1470
            .::.:     |:|                |...|.|...|.::...:.:.:.     |....||:
Zfish  1672 QESCILQVEFTKP----------------DRGGLGFALVGGVNGSTLRVKDICCGGVAEQDGRLR 1720

  Fly  1471 SNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINA-N 1534
            ..|   ...|...|..        |.|.|:|    ..::.......|||.....::.....:| |
Zfish  1721 VGD---ILLEVNGIIV--------SGLSHSK----VVDILRKAEGTVQLTVCRDILPMSACSASN 1770

  Fly  1535 Y-CDGYRKHNAY-VATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTR---IKCDQYWPTRGT 1594
            | .:.:...|.. .|.|.......|.|...|.|           .|:.:|   ..|.:..|:.|.
Zfish  1771 YPTEAHGNFNTLNSAAQTEAHPDHVSFHSDCPE-----------CEQESRNCTPTCQRCCPSLGV 1824

  Fly  1595 ETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPA--PFLQFLRR 1657
            ....| ..|..:.|.|...:::|......|::...|          :.|..|..|  |       
Zfish  1825 TDMLQ-EKTDPQKQHLENSAMKTEHSQSDGWSSDEE----------EDGDDDDCASQP------- 1871

  Fly  1658 CRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQY 1722
                :|||:.|:          ||..||.:..|..:                             
Zfish  1872 ----SPPETIPL----------TGRPIVSEEELSSL----------------------------- 1893

  Fly  1723 IFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEV--EFKKLSNVKMDSSKFVTAN 1785
                         .|...|....:|..:...:.:..|.:...::  ||..|.::. .|...:...
Zfish  1894 -------------AVISPPKNGQYTGSRVKALIQALEQLEKQDLVKEFMALEHLN-PSDNCLVGK 1944

  Fly  1786 LPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSA-----YIAAQGPVQDAA 1845
            .|.|:.|||...||||:.:||   |:...||  |:|||:|   |.:..     :|:||||:....
Zfish  1945 APENREKNRYREILPYDKTRV---PVGEDEG--YINASYI---RMKVGSEELFFISAQGPLPGTQ 2001

  Fly  1846 EDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSV-----RYQYYVVDPIAEYNMPQY-KL 1904
            :.||:|:||:.|.::.|:|:..|.||.||.:|||.:..|     |||.:    :..|.|..| .:
Zfish  2002 DSFWQMVWENRSDVIAMMTREVERGRVKCHKYWPEKLDVPKETSRYQLF----LDNYQMLGYFHI 2062

  Fly  1905 REFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVG 1969
            :..|:.:.:.|....|:..:|..||:.|.|.|.:..:.||..:.....:    ||||||||||:|
Zfish  2063 KVIKMVEKKSGDVHFVKHLKFTTWPDHGTPHSSDQLVRFIRYMRAVHAK----GPITVHCSAGIG 2123

  Fly  1970 RSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL 2024
            |:||.|...::|..:|.:..::|...|:.:|.||..|:||::||.|||:..||.|
Zfish  2124 RAGVLICTDVILSLIQKDLSINVSDIVKEMRLQRHGMIQTKEQYLFCYKVWLEVL 2178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151 18/101 (18%)
Ig strand B 53..57 CDD:409353 1/3 (33%)
Ig strand C 66..70 CDD:409353 2/3 (67%)
Ig strand E 93..97 CDD:409353 0/3 (0%)
Ig strand F 108..113 CDD:409353 0/4 (0%)
Ig strand G 122..125 CDD:409353 0/2 (0%)
Ig 141..228 CDD:472250 15/87 (17%)
Ig strand B 157..161 CDD:409353 0/3 (0%)
Ig strand C 170..174 CDD:409353 1/3 (33%)
Ig strand E 192..196 CDD:409353 0/3 (0%)
Ig strand F 206..211 CDD:409353 1/4 (25%)
Ig strand G 218..221 CDD:409353 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 19/102 (19%)
Ig strand A 237..239 CDD:409401 1/1 (100%)
Ig strand A' 244..248 CDD:409401 2/3 (67%)
Ig strand B 251..259 CDD:409401 2/7 (29%)
Ig strand C 264..270 CDD:409401 0/5 (0%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 3/7 (43%)
Ig strand E 286..291 CDD:409401 2/21 (10%)
Ig strand F 298..305 CDD:409401 3/6 (50%)
Ig strand G 309..318 CDD:409401 0/8 (0%)
FN3 322..411 CDD:238020 20/114 (18%)
FN3 <382..747 CDD:442628 84/540 (16%)
FN3 712..810 CDD:238020 22/153 (14%)
FN3 832..898 CDD:214495 17/85 (20%)
FN3 <867..1269 CDD:442628 73/482 (15%)
fn3 914..998 CDD:394996 15/90 (17%)
R-PTPc-LAR-1 1498..1735 CDD:350401 40/244 (16%)
R-PTP-LAR-2 1784..2021 CDD:350402 89/247 (36%)
ptpn20XP_002664234.3 Protein Kinases, catalytic domain 6..154 CDD:473864 20/86 (23%)
FERM_F1_FRMPD2 342..431 CDD:340716 19/103 (18%)
B41 344..546 CDD:214604 37/222 (17%)
FERM_C_PTPH13 542..643 CDD:270008 16/127 (13%)
PDZ1_FRMPD2-like 775..865 CDD:467284 9/89 (10%)
PDZ2-PTPN13_FRMPD2-like 947..1033 CDD:467254 15/91 (16%)
PDZ3_PTPN13_FRMPD2-like 1086..1172 CDD:467181 21/109 (19%)
KLF10_11_N <1286..>1401 CDD:425362 17/114 (15%)
PDZ4_PTPN13-like 1430..1514 CDD:467182 12/103 (12%)
PDZ_canonical 1525..1612 CDD:483948 22/109 (20%)
PDZ5_DrPTPN13-like 1678..1757 CDD:467273 19/109 (17%)
PTPc-N20 1973..2179 CDD:350444 78/217 (36%)

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