DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and ca16b

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_021332937.1 Gene:ca16b / 569183 ZFINID:ZDB-GENE-080818-1 Length:1382 Species:Danio rerio


Alignment Length:1292 Identity:371/1292 - (28%)
Similarity:558/1292 - (43%) Gaps:284/1292 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   950 VQFHKKIDHG-LGSERNMTLRK----------------AVFTNLEEN-----TEYIFRVRAYTKQ 992
            |:||....:| .|||.::..:|                ::.|.::|.     ....|:|......
Zfish   143 VEFHWGSTNGSAGSEHSINGKKFPVEMQIYFYNSDDFDSLSTAIKERRIIAAMAVFFQVATKDNI 207

  Fly   993 GAGPF--SDKLIV--ETERDMGR------APMSL------QAEATSEQTAEIWWEPVTSRGKLLG 1041
            .|.|.  ..|.:|  |.|.::|.      .|.||      ....|:...:::....:.||...|.
Zfish   208 AAEPIIAGLKRVVHHEKETNLGSFILRDLLPSSLGSYYRYTGSLTTPPCSKVVEWIIFSRPVYLS 272

  Fly  1042 Y---KIFYTMTAVEDLDDWQTKTVGLTES-----ADLVNLEKFAQYAVAIAARFKNGLGRLSEKV 1098
            |   :.||::...|..|  ..|:|....:     .||.:...|.  :..:.|.....:...::..
Zfish   273 YHQLEAFYSIFTTEQQD--HVKSVDYLRNNHRPIQDLDSRRIFK--SALMDAWMPETMASAADTE 333

  Fly  1099 TVRIKPEDVPLNLRAHDVSTHSMTLSWS-------PPIRLTPVNYKISFDAMKVFVDSQGFSQTQ 1156
            |.|: ...:|.|::.|.::..::.|:|.       |||    |.:.:|:..:|   |...|.:|.
Zfish   334 TSRV-CSSIPDNMKLHPLNRTALVLTWDRPSAVYHPPI----VGFLVSYSWVK---DEMPFEKTF 390

  Fly  1157 IVPKREIILKHYVKTHTINELSPFTTYNVNVSAI-----PSDYSYRPPTKITVT----------T 1206
            ....     :|..:. .|..:||...|...|.|:     .||:|.....|...|          |
Zfish   391 TQSS-----EHSTRA-VITLVSPDVLYLFRVQALCQRDQRSDFSQTLLFKANTTRIFEGTRIVKT 449

  Fly  1207 QMAAPQPMVKPDFYGVVNGEEILVI--LP----QASEEYGP------------ISHYYLVVVPED 1253
            .|....|....|...:.:|......  ||    ..:...||            ::...|..:...
Zfish   450 GMPTVSPASSADMAPISSGSSTWTSAGLPFSFVSMATGMGPPSSGGQATVASVVTSTLLAGLGFS 514

  Fly  1254 KSNLHKIPDQFL-TDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREK 1317
            .|.:..:|..|. |.....|.:..:.|..| .|...|...        |.|     |..|||.|:
Zfish   515 GSVISSLPGSFWPTHSTNTGPSPTQHPATP-TAENSPSED--------STD-----TQNKLEEEE 565

  Fly  1318 RYR---------------------------IFVRAVVDTPQ---------KHLYTSSPFSEFLSL 1346
            .::                           :.|:....|.|         ||.....|.:|..:|
Zfish   566 EHKKEDDEEEEEEEEEEEQRDEEKKKKGKDVTVKDKKQTVQKPTAPIPTSKHRDRERPDAESSTL 630

  Fly  1347 ---DMREAPPG--ERPHRPDPN---WPAE-----PEVSVNRNK--DEPEILWV------------ 1384
               ::.|...|  |||...|.:   |..:     |..|...:|  ||.:..|.            
Zfish   631 TPAEVEEQVSGATERPDAEDSSKATWQDDNDMQIPSSSTESSKLSDEEKANWPYYINTERNSIST 695

  Fly  1385 --------------VLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTP 1435
                          ::|||     |.:||.:||::                  ::.|.|      
Zfish   696 VSRDSVSSSSRMEWIIPLM-----VVSALTLLCLI------------------MLLAVL------ 731

  Fly  1436 SDPVDMRRLNFQT----------PGMI---SHPPI---------PISEFANHIERLKSNDNQKFS 1478
               |..||. |||          |.:|   |.|.|         |:.:|..||..|.||:...||
Zfish   732 ---VYWRRF-FQTAHFYIEDRNSPRVIHNDSFPIISTADDLEAMPVRQFIKHIMELHSNNRHGFS 792

  Fly  1479 QEYESIE---PGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVG--SDYINANYCDG 1538
            ||::.::   ...:.|.::||...||.||||.|:.|||||||:|..:.|...  ||||||||.||
Zfish   793 QEFDEVQHCTSEMKITAEHSNHPENKHKNRYINIVAYDHSRVKLQQLPGKDSKHSDYINANYVDG 857

  Fly  1539 YRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVT 1603
            |::..||:|.||||:.||.|||||.||..|..|||:|.|.|:.|.|||||||:..:|.||.|.||
Zfish   858 YKRARAYIAAQGPLKSTFEDFWRMIWEQNTTVIVMITNLVEKGRRKCDQYWPSENSEVYGNIMVT 922

  Fly  1604 ITETQELATYSIRTF-------QLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAL 1661
            :..|:..|.|::|.|       :..::|..:.|.:.|..:|.|||.|||::..|.|:|:.|....
Zfish   923 LKSTKVYAYYTLRHFIVRNSKLKKGQKGRQNERLVLQYHYTQWPDMGVPEYTLPVLKFISRSTVT 987

  Fly  1662 TPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIH 1726
            ....:|||:|||||||||||.||||||||:::|....:::.|.:..:|.||||:||||:|:||||
Zfish   988 HASSTGPVLVHCSAGVGRTGTYIVIDSMLKQIKDRGSVNVLGFLKHIREQRNYLVQTEEQFIFIH 1052

  Fly  1727 DAILEAIICGVTEVPARNLHTHLQKLLITEP-GETISGMEVEFKKLSNVKMDSSKFVTANLPCNK 1790
            ||::||::...|||.|..|||:...||...| |.|  .|:..||.|:......::.::....|||
Zfish  1053 DALMEAVLSKDTEVSAWQLHTYTNSLLTPSPTGHT--RMDKHFKLLTQCNAHLAECLSGQKECNK 1115

  Fly  1791 HKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEH 1855
            .|||...:||.|.:||.|:|:.|::|:||:|||:|.||...:.:|..|.|:.....|||||:|:|
Zfish  1116 EKNRTSAVLPTERARVALSPLPGLKGTDYINASYIMGYYRSNEFIITQHPLPHTTTDFWRMIWDH 1180

  Fly  1856 NSTIVVMLTKLKEMG-REKCFQYWP-HERSVRYQYYVV-----DPIAEYNMPQYKLREFKVTDAR 1913
            |:.::|||.  ..:| .|..|.||| .|..:....:.|     |.:...|..|..:.:|.:...:
Zfish  1181 NAQVIVMLP--DNLGLTEDEFVYWPSREEPMNCIAFTVTLINTDRLCLSNEEQLIIHDFILEATQ 1243

  Fly  1914 DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLS 1978
            |.....||.||..:||:.....|..  .:.|..:  .:|...:|||..||...|...:|.|..|:
Zfish  1244 DDYVLEVRHFQCPNWPDPDASISST--FELINII--KEEAMTRDGPTIVHDEFGAVSAGTFCALT 1304

  Fly  1979 IVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD-----NY 2030
            .:.::::.|..:||:|..:::...||.:....:.||:.|:|.|..:.|.|     ||
Zfish  1305 TLSQQLENESAVDVYQVAKMINLMRPGVFTEIEHYHYLYQAMLSLVSSKDFRFGFNY 1361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628
FN3 712..810 CDD:238020
FN3 832..898 CDD:214495
FN3 <867..1269 CDD:442628 79/405 (20%)
fn3 914..998 CDD:394996 14/71 (20%)
R-PTPc-LAR-1 1498..1735 CDD:350401 125/245 (51%)
R-PTP-LAR-2 1784..2021 CDD:350402 78/243 (32%)
ca16bXP_021332937.1 alpha_CARP_receptor_like 62..314 CDD:239396 35/172 (20%)
FN3 340..417 CDD:214495 20/89 (22%)
PTP_DSP_cys 791..1060 CDD:475123 132/268 (49%)
R-PTP-G-2 1144..1348 CDD:350508 62/209 (30%)
Blue background indicates that the domain is not in the aligned region.

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