DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and igsf9ba

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_009289969.2	Gene:	igsf9ba / 567389	ZFINID:	ZDB-GENE-060503-729	Length:	1475	Species:	Danio rerio

Alignment Length:	1743	Identity:	341/1743 - (19%)
Similarity:	554/1743 - (31%)	Gaps:	586/1743 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYC----AARGDPPPSIV-WRKNG 73
            ::.|:.|:.: |..|....||  .:..:||....|.|......|    ...|...|.:| |.|.|
Zfish     5 VATLIASVFS-TRGTAAQGAH--GVREEPQFVTARAGESVVLGCDVSHPLNGQQTPYVVEWFKFG 66

  Fly    74 KKV-----------------SGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYEC---------- 111
            ..:                 :|..|.:       |.:.|:||.||: .|...|||
Zfish    67 VPIPFFINFRFYPPHVDPEYAGRASLH-------GKASLQIEQVRS-EDQGWYECRVLMLEQQYD 123

  Fly   112 VAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEV--GHTVLMTCKAIGNPTPNIYWI 174
            ...||....::.:|..|..:   ||..:           :|.  |.::.:||.|.|||.|.:.|:
Zfish   124 TFHNGSWVHLTVNAPPTFSD---TPPQY-----------VEAREGGSITLTCTAFGNPKPVVTWL 174

  Fly   175 KNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRP 239
            :...:: .|..:|::.||.|.::....||:|.|.|.|.:..| |....|.|.|   :.||....|
Zfish   175 REGDQL-TSTRKYTVSDGSLTVQAITREDRGAYSCRAHSDQG-EALHTTRLLV---QGPPYIVTP 234

  Fly   240 PETISEVMLGSNLNLSCIAVGSP--MPHVKWMKGSEDLTPENEMPI-------GRNVLQLINIQE 295
            ||.|: |.:..|...:|.|...|  :.:. |....:::..:|::.:       |..::..:..::
Zfish   235 PENIT-VNISQNAQFTCQAEAYPGNLTYT-WYWEEDNVYFKNDLKLRVRIFIDGTLIIYRVKPED 297

  Fly   296 SANYTCIAASTLGQIDSVSV-------VKVQSLP-------------TAPTDVQISEVTATSVRL 340
            :..|||..:::||...|.|.       .:|.::|             ..|.|   :....||||
Zfish   298 AGKYTCSPSNSLGISPSASAYLTVQYPARVVNMPPVIYVPRKLSGIIRCPVD---ANPPVTSVR- 358

  Fly   341 EWSYKG-PEDLQYYVIQYKPKNANQAFSEIS-GIITMYYVVR-ALSPYTEYEFYVIAVNNIGRGP 402
             |...| |..::.|          ..:|::: |.|.:..|.. :|..||     .:..|.:|...
Zfish   359 -WEKDGYPLRIEKY----------PGWSQMTDGSIRVAEVTEDSLGTYT-----CVPYNVLGTMG 407

  Fly   403 PSAPATCTTGDFSF-----GGTKMESAPRNVQVRTLSS---STMVITW----EPPETPNGQVTGY 455
            .|.|||....|..:     ||...:.|.|.:.:...:|   ....|.|    :|..:.:..:...
Zfish   408 QSPPATLVLKDPPYFNVRPGGEYRQEAGRELVIPCAASGDPEIPTIQWRKVGKPSRSKHNLLPSG 472

  Fly   456 KVYYTTNSNQPEASWNSQMVDNSELTTVSELT--------PHAIYTVRVQAYTSMG--------- 503
            .:.:.:.|.:....|  :.|..:.:|:::..|        |||...|.|.|.||..
Zfish   473 SLQFVSLSKEDHGEW--ECVATNVVTSITASTRLFVIGTSPHAPTNVHVSASTSSANVSWEPGYD 535

  Fly   504 AGPMST------PVQVKAQQGVPSQPSNFRATDIGETAVTLQWTK-PTHSSENIVHYELYWNDTY 561
            .|...|      ||:||              .|:|    |..|.. |...|:       .|
Zfish   536 GGFEQTFSVWYGPVKVK--------------NDVG----THDWLSIPVPGSQ-------MW---- 571

  Fly   562 ANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYG----------AP 616
                          ..:.||.|.|.|...:.|:::.|.|..:..:.|.|..|.          .|
Zfish   572 --------------LVVQGLEPKTAYQFSVLAQNKLGTGPFSEVVTVTTGGYPISTPEPLVLLTP 622

  Fly   617 PRNITAIATSSTTISLSWLPP-----PVERSNGRIIYYKVFFVEVGRE----DD--EATTMTLNM 670
            ||.:||..|....: |:||||     |::|       |.:.| .:|.:    ||  .||...:..
Zfish   623 PRCLTANRTQQGVL-LTWLPPANHTSPIDR-------YVIEF-RLGEKWEVLDDLIPATETEIIA 678

  Fly   671 TSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPP 735
            ..::.|.   |.|::                  .|...:|:..:..:|  ..::||...    ||
Zfish   679 RDLIQDS---WYEFR------------------ALAIMDDLVSESSNV--VGVSSTDPF----PP 716

  Fly   736 LEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQV-----AALT 795
                            .|:.|||   |.:|....:|.|:.|....:...|..:..|     ..|.
Zfish   717 ----------------TEISDEG---LAKPVVAGIVATICFLAAAILFSTLAACFVNKQHRRKLK 762

  Fly   796 RKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWE-------RPAQTYGELR----- 848
            ||.|...|   :..|...:...|.::       |:..||..||       ||..|..:|.
Zfish   763 RKRDPPLS---ITHTRKSIESPPPLT-------PLPGIEPYWEEPDRSSYRPPSTSPQLSSGKIS 817

  Fly   849 ----------------GYRLRWGVKDQALKEEMLSGPQMTKKRFDN------------------L 879
                            |:.|.........||:.||..:.||:...:                  :
Zfish   818 PESIASSRPPSLASVGGHGLYVKKLPSPRKEKELSLYKKTKRAITSKKYSVSKHEAEVTTPIELI 882

  Fly   880 ERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGI 944
            .||.:..| |...|.|....:..:|    ||.|....|::...|:..|
Zfish   883 SRGPDGRF-VMDPNDIDSSLKPRRI----EGFPFVEESDLYPEFRQSD----------------- 925

  Fly   945 ITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDM 1009
                    .:..|.|.......|||..: :.:..:.|...:..||:.:...|.....|.|..|
Zfish   926 --------EENDDPGPLPPVMATLRPQI-SPVSSSQESYMQPPAYSPRFQRPMEGMSISEGSR-- 979

  Fly  1010 GRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGY----------KIFYTMTAVEDLDDWQTKTVGL 1064
                  |||...|..:   .:..|...|...||          ..||       :.|...::..:
Zfish   980 ------LQATGQSRVS---HFHRVFPPGPFYGYIGSGAEVELHPPFY-------MPDVSPRSSAM 1028

  Fly  1065 TESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPED-VPLNLRAHDVSTHSMTLSWSPP 1128
            :.|........|....:                      ||: ..|.:..:..|.|::.|..|||
Zfish  1029 SSSPSYPPEGPFRHPTI----------------------PEEREELRIHQYGASGHALPLVHSPP 1071

  Fly  1129 -IRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTH-TINELSPFTTYNVNVSA-- 1189
             .|.|.:.....|.    |:..:|       |:..:..:|....| .:.|..|:.:::..||.
Zfish  1072 SSRSTEIWQPPDFP----FLGQEG-------PRLALPPRHSSYLHRDLPEPPPYPSHSRTVSTTS 1125

  Fly  1190 -IPSDYSY----RPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVV 1249
             :||..::    .|.|.::.:.....||            |.....|..|.::..|.:.|
Zfish  1126 QLPSSSAFLQLEAPRTHLSRSPGRFPPQ------------GPSAKHITMQQAQTLGQLRH----- 1173

  Fly  1250 VPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTN---- 1310
                  ..|             |...|.   .||..|.....| |.|.|..|.|.:.:...
Zfish  1174 ------TAH-------------GMGVPV---LPYSGATTRMGS-PSTLHSESSDGWRSEAQPWMS 1215

  Fly  1311 ----RKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPD----PNWPAE 1367
                ||::      :.::.||..|.:    .||        :.:.||......||    |  |..
Zfish  1216 PRAARKMD------LGLQQVVLQPSR----LSP--------LTQTPPSSHAGSPDILVRP--PPR 1260

  Fly  1368 PEV-SVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGA 1431
            |.: ..:|:::.||                              ..:.|...:.:|..:::....
Zfish  1261 PSILRSSRSQEMPE------------------------------SARHPASVSFSRRSLSSSPAT 1295

  Fly  1432 GPTPSDPVDMRRLNFQT-----------PGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIE 1485
            .||.........|:::.           |.....||...|:....:...:..|.:....|   ..
Zfish  1296 SPTQGQSGQRPSLSYRAHMAFATAAASYPSQSPSPPAESSDAFGQMPSQRRTDEEMLPSE---PS 1357

  Fly  1486 PGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINA--NYC 1536
            ||          ||                   |.||....||:...|  |||
Zfish  1358 PG----------EH-------------------LGAVRVPAGSESFEALINYC 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	26/125 (21%)
		I-set	36..129	CDD:254352	26/124 (21%)
		IG_like	146..227	CDD:214653	25/82 (30%)
		Ig	159..228	CDD:299845	23/68 (34%)
		I-set	234..318	CDD:254352	20/99 (20%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	14/83 (17%)
		fn3	324..404	CDD:278470	19/82 (23%)
		FN3	423..514	CDD:238020	23/120 (19%)
		FN3	520..610	CDD:238020	16/90 (18%)
		FN3	616..707	CDD:238020	24/101 (24%)
		FN3	712..810	CDD:238020	21/102 (21%)
		FN3	832..907	CDD:238020	23/120 (19%)
		FN3	914..1005	CDD:238020	13/90 (14%)
		FN3	1012..1101	CDD:238020	13/98 (13%)
		fn3	1106..1198	CDD:278470	21/101 (21%)
		PTPc	1476..1731	CDD:214550	14/63 (22%)
		PTPc	1503..1731	CDD:238006	9/36 (25%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
igsf9ba	XP_009289969.2	IG	30..115	CDD:214652	23/92 (25%)
		I-set	139..225	CDD:254352	28/101 (28%)
		I-set	229..321	CDD:333254	20/93 (22%)
		Ig	345..415	CDD:325142	23/89 (26%)
		Ig	438..503	CDD:319273	8/66 (12%)
		FN3	511..606	CDD:238020	30/137 (22%)
		FN3	622..706	CDD:238020	26/115 (23%)
		Atrophin-1	<924..1361	CDD:331285	100/616 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900