DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and lifrb

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_009293599.1	Gene:	lifrb / 565104	ZFINID:	ZDB-GENE-080107-2	Length:	960	Species:	Danio rerio

Alignment Length:	1211	Identity:	231/1211 - (19%)
Similarity:	374/1211 - (30%)	Gaps:	414/1211 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 IDSVSVVKVQSLPTAPTDVQIS-EVTATS------VRLEWSYKGPEDLQYYVIQYKPKNANQAFS 367
            :..:.:.:...||.:..||::| |.|.||      :.:||:                 :.|..|.
Zfish    11 VSLIELAEQDGLPLSIRDVKVSEEKTETSKDGAWVLNVEWT-----------------DENNEFE 58

  Fly   368 EISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRT 432
            ::|                 |:..:|....:           .|..|           .|:.|:.
Zfish    59 KVS-----------------YDIEIIHTEQM-----------RTVHF-----------ENIHVKA 84

  Fly   433 LSSSTMVITWEPPETPNGQVTGYKV--------------YYTTNSNQPEASWNSQMVDNSEL--- 480
            ..||.....|..| .|. |.|.:.|              .|.|.:.|.:.|..||:...:::
Zfish    85 DKSSHYHWKWTSP-IPL-QCTSHSVRLRRRDQLRISEWTSYLTYTGQDQNSLTSQVYPRNQVFLI 147

  Fly   481 -----------TTVSELTPHAIYTVRV--QAY-TSMGAGPMS--------TPVQVKAQQ------ 517
                       |..:.|...:.:.:|:  :.| |.....|.|        ...:||.::
Zfish   148 GSNITFCCILKTEKASLNNLSKFVIRISNRTYITETHKDPFSRTSEYFSDVDCEVKNEKSSSGAS 212

  Fly   518 ---GVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLD 579
               |.|....|.       |.:|          .::...|..|......|.:..|.:|   |||:
Zfish   213 VFFGYPPDDQNL-------TCIT----------RDLSSVECQWKLGRKTQLYGTRATN---YTLN 257

  Fly   580 G----------LYPDTLYYIW-LAARSQRGEGATTPPIPVRTKQYGAPPRNIT-AIATSSTTISL 632
            |          |........| |.||:..|....|.......:.:...|.||: |....:.|:..
Zfish   258 GRKCEFNRCDPLELKKQITNWTLIARNALGVKIVTDTGDPTHRVWLKAPHNISHAAHARNATVHW 322

  Fly   633 SWLPPPVERS----------NGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIW 687
            ||  ...|.:          ||. ||.|.|   .|:          .:.|:||:.|:.:|:|...
Zfish   323 SW--SVTEYASLLMICQVMLNGN-IYNKTF---SGK----------GLASVVLEHLQPFTKYTAK 371

  Fly   688 VLAGT-----SVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGY 747
            |..|:     ..||...   |...|:||:| :..|| ....:....::.|||...:..:|||.||
Zfish   372 VSCGSHEHFFQWGDWSE---ITFTTKEDIP-ELVDV-WIQYSENHTYIQWKPLSHQQSHGIITGY 431

  Fly   748 HIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPG 812
            .:....::.......||         |.:::..........|:::|....|....|..||...||
Zfish   432 KLTMNTIKSPVNIGANE---------LCYSIASENEKNNQIIKLSAKNSAGLSPPSVLIVPHDPG 487

  Fly   813 GVPVRPTVSLKIMEREPIVSIELEWER-PAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTK--- 873
                 ..||:.:: .......|:.|:. |..|.    ||.:.|             .|...|
Zfish   488 -----KGVSISLI-NSTNGGFEVFWKMYPKSTC----GYVVEW-------------FPTYNKTQC 529

  Fly   874 ----KRFDNLERGV------EYEFRVAGSNHIGIGQETVKIF----------QTPEG-----TPG 913
                |:....:..|      ..||: ||..:      |:.:|          |..||     .|.
Zfish   530 AVDWKKIPECDEDVCQTWIPPVEFK-AGERY------TISVFACTNGAPVLLQRSEGYAIEQEPQ 587

  Fly   914 GPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLR----KA--V 972
            |...|:..: |....:.::|.....:.:.|||..|.|    ||.|   ||....::    ||  |
Zfish   588 GTVQNLHGQ-QNGRNVELSWKEVALDQQKGIILGYKV----KITH---SESKKVIKTIETKACEV 644

  Fly   973 FTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRG 1037
            ...|:..: |||.|||:|..|          |:|    .|.:::..|.|.:|..     ..|..|
Zfish   645 ILPLDPGS-YIFTVRAFTSVG----------ESE----DAILTMNVETTIDQML-----AATLVG 689

  Fly  1038 KLLGYKIFYTMTAV-----EDLDD--------------WQTKTVGLTESADLVNLEKFAQYAVAI 1083
            ......:|..:|.:     |.|.|              |.|:.:..|:..:
Zfish   690 CSAATLVFIIITVLCYRKREWLKDLLYPDIPEPKLAGKWTTQGIYCTQMTE-------------- 740

  Fly  1084 AARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVD 1148
                    |.:..::. .:...|.|.:...|.:..|   .|..|.....|:.|..:|...|
Zfish   741 --------GYVKCEIQ-EVHGSDHPTSENPHGLDHH---CSKKPLFPAQPLYYNTTFPCAK---- 789

  Fly  1149 SQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQP 1213
                ..|.|:..         .::.:....|......:...:....||.|.:|..        ||
Zfish   790 ----KLTSIIEN---------PSYNLTTPGPVDVVQTSKPLLEMQDSYLPASKFA--------QP 833

  Fly  1214 MVKPDFYGVVNGEEILVILPQASEE---YGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNK 1275
            :...:....:...:.:..||.|.|:   :.|.|                            |:..
Zfish   834 VCHSEQDSYLPAPKFVQPLPIAVEDTYIFAPTS----------------------------GKTT 870

  Fly  1276 PERPNAPYI-AAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDT---------P 1330
            |......|: |.||.|..   :.|:   :|.|      |...|..:.|...|.||         |
Zfish   871 PIHVEDTYLPAPKFGQAP---SIHV---EDIH------LPAPKSVQQFSILVEDTYLPAPKFVQP 923

  Fly  1331 QKHLYTSS--PFSEFLSLDMREAPPGERPHRPDPNWPAEPE 1369
            ..:|...|  |..:|:.      |...:.:..|.|...:|:
Zfish   924 SNNLVQDSYLPAPKFIQ------PNFAQNNVIDKNTAGKPQ 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352	0/7 (0%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	0/6 (0%)
		fn3	324..404	CDD:278470	14/86 (16%)
		FN3	423..514	CDD:238020	23/129 (18%)
		FN3	520..610	CDD:238020	20/100 (20%)
		FN3	616..707	CDD:238020	26/106 (25%)
		FN3	712..810	CDD:238020	20/97 (21%)
		FN3	832..907	CDD:238020	17/98 (17%)
		FN3	914..1005	CDD:238020	26/96 (27%)
		FN3	1012..1101	CDD:238020	15/107 (14%)
		fn3	1106..1198	CDD:278470	15/91 (16%)
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
lifrb	XP_009293599.1	FN3	222..>256	CDD:304408	9/53 (17%)
lifrb	XP_009293599.1	FN3	588..666	CDD:214495	26/96 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910