DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and ptprua

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_005159609.1 Gene:ptprua / 563584 ZFINID:ZDB-GENE-060503-232 Length:1478 Species:Danio rerio


Alignment Length:1754 Identity:445/1754 - (25%)
Similarity:687/1754 - (39%) Gaps:499/1754 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   438 MVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAI---YTVRVQAY 499
            :|.|:..|...:..:.|  .|...|::|..|...:|::    |..:||...|.:   |.:    |
Zfish    51 LVRTYSWPHMTSDLIRG--SYMLVNASQYGAGQRAQLM----LRPLSENDTHCVQFSYFL----Y 105

  Fly   500 TSMGAGPMSTPVQVKAQQGVPSQP------SNFRATDIGETAVTLQWT-------KPTHSSEN-- 549
            :..|..|....|.|:...|.....      |..|.....|.||:..|.       :.|.|||.  
Zfish   106 SRDGHSPGGLNVYVRVNGGSRGNAVWNVSGSQGRQWHQVEMAVSTFWPSEYQIVFEATISSEQKG 170

  Fly   550 --------IVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPI 606
                    :::|..|      ...|..|:.:.|.                    ..|:.||...:
Zfish   171 YIGLDDIVLLNYPCY------KVPHFSRLGDVEV--------------------NAGQNATFQCV 209

  Fly   607 ----PVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRII-YYKVFFVEVGREDDEATTM 666
                .|:|..:....||...:|..|.|.|:.      ||   |:: :::|...:.|.:|      
Zfish   210 ATGRSVKTDPFLMERRNGVLMAPYSVTSSIG------ER---RLVAWFQVGGAQRGEQD------ 259

  Fly   667 TLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATP------LNS 725
                       |.|......:..|.::..:      :|:|........||.:::.|      ||:
Zfish   260 -----------LYRCITQSTFGAAVSNFAE------LIVRVPPTPIAPPQLLRSGPTYLIIQLNT 307

  Fly   726 TSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQ 790
            .|| |...|.:.  |..:.|..|....|...              |::|.:.|..|:|||:|.|.
Zfish   308 NSI-VGDGPVIR--REIVYRASHSPWSETHG--------------VNSLTYKVWHLEPDTEYRIS 355

  Fly   791 VAALTRKGDGDR---SAAIVVKTPGGVPVRPTVSL---KIMEREPIVSIELEWERPAQTYGELRG 849
            | .|||.|:|..   ...:|.:|....|:||...|   :|..|:    :.|:||...........
Zfish   356 V-LLTRPGEGGTGPPGPPLVSRTKCAEPMRPLRGLTATEIQSRQ----LLLQWEPVGYNLTRCHT 415

  Fly   850 YRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVE------------YEFRVAGSNHIGIGQETV 902
            |.|....:..........|...|.:...::||...            ...|:|.:|..|..:...
Zfish   416 YSLSLCYRYSTATGGGAGGNNATVRECLSVERNTSRFTLRDLPPFHTVHVRLALANPEGKKESRE 480

  Fly   903 KIFQTPEGTPGG-PPSNITIRFQTP--DVLCVTWDPPTREHRNGIITRYDVQFH--KKIDHGL-- 960
            ..|||.|..||| .|.::|.   ||  |::.:.|:.|...  ||:||:|::.:.  :..|..:  
Zfish   481 VTFQTEEDIPGGIAPESLTF---TPLDDMIFLKWEEPLEP--NGLITQYEISYQSIESSDPSINV 540

  Fly   961 -GSERNMTLRK----AVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEA 1020
             |..|.::..|    .:|:.|...|.|:..|||.|.:|.|                         
Zfish   541 PGPRRTVSKLKNETYHMFSGLHPGTTYLVSVRARTAKGFG------------------------- 580

  Fly  1021 TSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAA 1085
               |||                                     |||....::...| .|      
Zfish   581 ---QTA-------------------------------------LTEITTNISAPAF-DY------ 598

  Fly  1086 RFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPI-RLTPVN-YKISFDAMKVFVD 1148
                               ||||..|   ..|..::|:...|.: |..||: |.:      |.|:
Zfish   599 -------------------EDVPSPL---SESESTITVLLRPALGRGAPVSTYHV------VVVE 635

  Fly  1149 SQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQP 1213
            ..|..|   |.:||  |.|                   :...|:                     
Zfish   636 EDGSRQ---VRRRE--LGH-------------------MECFPA--------------------- 655

  Fly  1214 MVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPER 1278
               |..:|..:|           ...|...|||                   |.:|.|. :.|| 
Zfish   656 ---PSSHGETSG-----------GAGGTPPHYY-------------------TAELSPS-SLPE- 685

  Fly  1279 PNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIF------------------VRA 1325
                         :.|||  :|....|..:.|..|:..|.|.|:                  .|.
Zfish   686 -------------ATPFT--VGDNHTYSGYWNTPLDPSKNYLIYFQASSNFRGETRINCIRIARK 735

  Fly  1326 VVDTPQKHLYTSSPFSEFLSLDMREAPPG--------------ERPHRPDPNWPAEPEVSVNRNK 1376
            |.....|.....|..:|.:.|.:.....|              .:..|...::|..|...||.||
Zfish   736 VACKDHKRALEVSQHAEDMGLILGACAGGLVVLILLLGAIVVIVKKGRDIYSYPYYPRKKVNINK 800

  Fly  1377 DEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCK-------TPDQAAVTRPLMAAD------ 1428
                        .|.|:             |:.:.||       |.:.:.:.:....|.      
Zfish   801 ------------AVMTY-------------RQEKTCKLGSLDCSTTEHSTLQQDDRTAHTFLDSH 840

  Fly  1429 ------------------LGAGP-----TPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLK 1470
                              ||..|     ..|.|....:|         ||.:.:::...||.::|
Zfish   841 NCTARNEQRSTVNESSSLLGGSPRRHCRRKSSPYHTGQL---------HPAVRVADLLQHINQMK 896

  Fly  1471 SNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANY 1535
            :.:...|.|||||...|    || .|.:.:|:|.|:..:...|..||::.::.....|||:||||
Zfish   897 TGEGYGFKQEYESFFDG----WD-INDKKDKTKGRHDTLLGQDRHRVKMHSLLADPNSDYVNANY 956

  Fly  1536 CD------GYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGT 1594
            .|      ||::.|.::|||||.|:...|||||.|:....:|||:|:|.|..|:||.:|||. .:
Zfish   957 IDIRINREGYQRSNHFIATQGPKQDMIYDFWRMVWQENCYSIVMITKLVEVGRMKCCKYWPD-DS 1020

  Fly  1595 ETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCR 1659
            |.||.|.:|:.:|:.||.|::|||.:.|:|:..:.|:.|..||:||:||||.|....|.||||.:
Zfish  1021 ELYGDIKITLLKTETLAEYTVRTFAMERRGYPAKHEVCQFHFTSWPEHGVPYHATGLLAFLRRVK 1085

  Fly  1660 ALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIF 1724
            |.|||::|||:||||.|.||||||||:|.||:..:.|.::|||..|..|.::|..|:|||:||||
Zfish  1086 ASTPPDAGPVVVHCSMGAGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRINMIQTEEQYIF 1150

  Fly  1725 IHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDSSKFVTANLP 1787
            ||||||||.:||.|.:|........:.:|..:.....|.:..||:.|::|  .:|..:...:.||
Zfish  1151 IHDAILEACLCGETAIPITEFGLSYKDMLSVDSQTNTSQLREEFQTLNSVTPHLDVEECSVSLLP 1215

  Fly  1788 CNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRML 1852
            .|:.|||.:.:||.:.:..:|....| :|::|:||:.:|.:...:|::....|:.....||||::
Zfish  1216 RNREKNRSMDVLPPDRALAFLVSNEG-DGNNYINAALMDSFLQPAAFVVTPHPLPTTTTDFWRLV 1279

  Fly  1853 WEHNSTIVVMLTKLKEMGRE-KCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVT----DA 1912
            :::..|.:|||.:|.:.... .|.||||.....:|....|:.::.........|.|:|.    |.
Zfish  1280 FDYGCTSIVMLNQLNQSNSAWPCLQYWPETGMQQYGPMTVELLSRSTDENVVTRLFRVNNITRDP 1344

  Fly  1913 RD------GSSR----------TVRQFQFIDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1960
            |:      ..||          .||.|||:.|.. :.:|.|.:.|::.:.||.|.:.:.| ||..
Zfish  1345 RENLPCWNADSRIPKKLQEGHLVVRHFQFLRWSAYREIPDSKKAFLNLLAQVQKWQRECG-DGRT 1408

  Fly  1961 TVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL 2024
            .|||..|.||||.|...::::|.:.:..::|||..|:.||:.:|.||::.:||.|||..|||||
Zfish  1409 IVHCLNGGGRSGTFCACTMIMEMVHHHNMVDVFYAVKTLRNSKPNMVESMEQYRFCYELALEYL 1472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020 18/78 (23%)
FN3 520..610 CDD:238020 19/116 (16%)
FN3 616..707 CDD:238020 16/91 (18%)
FN3 712..810 CDD:238020 29/106 (27%)
FN3 832..907 CDD:238020 14/86 (16%)
FN3 914..1005 CDD:238020 27/102 (26%)
FN3 1012..1101 CDD:238020 8/88 (9%)
fn3 1106..1198 CDD:278470 21/93 (23%)
PTPc 1476..1731 CDD:214550 124/260 (48%)
PTPc 1503..1731 CDD:238006 113/233 (48%)
PTPc 1763..2022 CDD:214550 85/282 (30%)
PTPc 1791..2022 CDD:238006 77/252 (31%)
ptpruaXP_005159609.1 MAM 26..186 CDD:279023 32/150 (21%)
MAM 26..184 CDD:99706 31/142 (22%)
I-set 188..281 CDD:254352 23/144 (16%)
FN3 285..356 CDD:214495 22/87 (25%)
FN3 385..485 CDD:238020 18/103 (17%)
FN3 494..589 CDD:238020 32/164 (20%)
Y_phosphatase 922..1157 CDD:278528 114/235 (49%)
PTPc 934..1157 CDD:238006 111/223 (50%)
PTPc 1189..1470 CDD:214550 85/282 (30%)
PTPc 1219..1470 CDD:238006 77/252 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.