DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptprga

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001316793.1 Gene:ptprga / 561197 ZFINID:ZDB-GENE-101101-4 Length:1414 Species:Danio rerio


Alignment Length:1646 Identity:437/1646 - (26%)
Similarity:669/1646 - (40%) Gaps:430/1646 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   534 TAVTLQWTKPTHSSENIVHYELYWNDTYANQ-----AHHKRISNSEAYTLDGLY-PDTLYYIWLA 592
            :::.|:|..        .|..|...|...|.     ..|:|.:....:...|.| |||       
Zfish    20 SSLVLRWAH--------CHPALAEGDKSENHDRPIGDRHRRAAEESYWAYSGTYGPDT------- 69

  Fly   593 ARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVG 657
                 |..|..|....|.:.    |.|   ||...|.:|:.              |.::......
Zfish    70 -----GWAAAFPECQERNQS----PIN---IADQDTKVSME--------------YQELTLDGFD 108

  Fly   658 REDDEATTMTLNMTSIVLDELK------------RWTEYKIWVLAGTSVGDGPRSHPIILRTQED 710
            .|....|:|. |....|...||            |:...|:....|.|.|.....|.|..|.   
Zfish   109 AESSNKTSMK-NTGKTVAIFLKDDYFVRGAGLPGRFKAEKVEFHWGQSNGSDGSEHSINGRR--- 169

  Fly   711 VPGDPQDVKATPLNS-------TSI-------------HVSWK--PPLEKDRNGIIRGYHIHAQE 753
               .|.:::....||       |:|             .|.:|  |.::...:| :||...|.:|
Zfish   170 ---FPVEMQIFMYNSDDFDSLNTAIREKRVIAAMAVFFQVDFKDNPAVDPIIHG-LRGVVHHEKE 230

  Fly   754 LRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDT--KYSIQVAALTRKGDGDRSAAIVVKTPGGVPV 816
            .      || |||.          :..|.|.:  .|...:.:||              ||   |.
Zfish   231 T------FL-EPFV----------LRDLLPSSIGSYYRYIGSLT--------------TP---PC 261

  Fly   817 RPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLER 881
            ...|...:..|..::|           |.:|..:   :.:              .|.::.|:: :
Zfish   262 SKVVEWIVFSRPVLLS-----------YKQLEAF---YSI--------------FTTEQQDHV-K 297

  Fly   882 GVEY---EFRVAGS-NHIGIGQETVKIFQTPEGT--PGGP------------PSNITIRFQTPDV 928
            .|||   .||...| ::..:.:..||....|:.|  ||.|            |.|:.::......
Zfish   298 SVEYLRNNFRPLQSLDNREVFKSAVKDAWLPDLTYPPGNPYGTEASKACSSAPINMNVQHMNKTA 362

  Fly   929 LCVTWDPPTREHRNGII--------TRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFR 985
            |.|.|..|...:...||        ||.|..:.:  .:..||::.:   :||.|.:..:..|:||
Zfish   363 LVVRWSRPEITYDPPIISYLISYSWTRNDESYEE--TYFKGSDQKL---EAVITPVSPDVLYLFR 422

  Fly   986 VRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTA 1050
            |:|..      .:||     ..|..:: |..:|..|                     :||     
Zfish   423 VQAVC------LNDK-----RSDFSQS-MLFRANTT---------------------RIF----- 449

  Fly  1051 VEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHD 1115
                           |...:|                |.|:..:|...:..:.|           
Zfish   450 ---------------EGTRIV----------------KTGMPTVSPASSADMAP----------- 472

  Fly  1116 VSTHSMTLSWSPPIRLTPVNYKISFDAMKVFV-DSQGFSQTQIVPKREIILKHYVKTHTINELSP 1179
            :|:.|.|  |      |......||.:|...: .|...||..:..         |.|.|:  |:.
Zfish   473 ISSGSST--W------TSSGLPFSFVSMATGIGPSSSGSQATVAS---------VVTSTL--LAG 518

  Fly  1180 FTTYNVNVSAIPSD-YSYRPP--TKITVTTQMAAPQPMVK------------------------- 1216
            .......:|:.||. :..|||  :....:|..:..:|:|.                         
Zfish   519 LGFSGGVISSFPSSVWPTRPPPSSPAPASTHQSPAKPVVTTAEQASDADTTTATDNDRSDDGGEK 583

  Fly  1217 ----PDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPED-----KSNLHKIPDQFLTDDLLP- 1271
                .|..|..||||    .....||.|..|....  .|:|     .|::.|.|...:.|.... 
Zfish   584 GGKGEDEDGEKNGEE----EEDEDEEKGGESKDSR--APDDVEKQTNSSVSKDPPTAVPDSTAKE 642

  Fly  1272 --GRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHL 1334
              ||.:.|...||   ::..:.:..     |.|::.   |.....||......|.||::||:.  
Zfish   643 KGGRRRTENSTAP---SRVSEENTQ-----GLGEEN---TQVMASREPEVEENVTAVIETPEN-- 694

  Fly  1335 YTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEV--SVNRNKDEPEILWVVLPLMVS--TFIV 1395
                  :|..|.|.|    |:|.|.|..:...|..|  |:........:.|::..::||  ||:.
Zfish   695 ------TEQSSKDNR----GDRNHLPPFSIHTERTVVSSMYPGPAAGRMEWIIPLVVVSALTFLC 749

  Fly  1396 STALIVLCVVKRR------------RQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQT 1448
            ...|:.:.|..||            ..|...|:::....|:             |.||.      
Zfish   750 LILLLAVLVYWRRCFQTAHFYVEDSNSPRVVPNESIPVIPI-------------PDDME------ 795

  Fly  1449 PGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIE---PGQQFTWDNSNLEHNKSKNRYANVT 1510
                   .||:..|..|:..|.||:...||.::|.::   ...:.|.::||...||.||||.|:.
Zfish   796 -------AIPVKHFIKHVSELYSNNQHGFSDDFEEVQRCTADMKITAEHSNHPDNKHKNRYINII 853

  Fly  1511 AYDHSRVQLPAVEGVVG--SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVM 1573
            |||||||:|..:.|...  ||||||||.|||.|..||:|.||||:.||.|||||.||..|..|||
Zfish   854 AYDHSRVKLRPLAGKDSKHSDYINANYVDGYNKPKAYIAAQGPLKSTFEDFWRMVWEQNTGIIVM 918

  Fly  1574 MTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCR-----------QGFND 1627
            :|.|.|:.|.|||||||:..:|.||.|.||:..|:.:|.|::|.|.:..           :|...
Zfish   919 ITNLVEKGRRKCDQYWPSENSEEYGNIVVTLKRTKVMACYTLRIFTIRNTKVKKGQKGNTKGRQS 983

  Fly  1628 RREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLER 1692
            .|.:.|..:|.|||.|||::..|.|.|:|:..|...|:.||::|||||||||||.||||||||::
Zfish   984 ERTVLQYHYTQWPDMGVPEYTLPVLTFVRKSSAAQTPDMGPMLVHCSAGVGRTGTYIVIDSMLQQ 1048

  Fly  1693 MKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEP 1757
            :|.:..:::.|.:..:|.||||:||||:||||||||::|||:...||||:..||:::..:|...|
Zfish  1049 LKDKGAVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALMEAILGKETEVPSSQLHSYVNSILTPGP 1113

  Fly  1758 GETISGMEVEFKKLSNVKMDSSKFV---TANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDY 1819
            |.. :.:|.:||.::..   :::||   :|...|||.|||...::|.|.:||.|.|:.|::|:||
Zfish  1114 GGK-TRLEKQFKLVTQC---NARFVECFSAQKDCNKEKNRNSSVVPSERARVGLAPLPGMKGTDY 1174

  Fly  1820 VNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWP-HERS 1883
            :|||:|.||...:.:|..|.|:....:|||||:|:||:.|:|||...:.:..:: |.||| .|.:
Zfish  1175 INASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQGLAEDE-FVYWPSREEA 1238

  Fly  1884 VRYQYYVV-----DPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDF 1943
            :..:.:.|     |.:...|..|..:.:|.:...:|.....||.||...||....|.|..  .:.
Zfish  1239 MNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FEL 1301

  Fly  1944 IGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQ 2008
            |..:  .:|...:|||..||...|...:|:|..|:.:.::::.||...|:|..:::...||.:..
Zfish  1302 INVI--KEEAMTRDGPTIVHDEFGAVSAGMFCALTTLSQQLESEGAAGVYQVAKMINLMRPGVFT 1364

  Fly  2009 TEDQYHFCYRAALEYLGSFDN 2029
            ..:||.:.|:|.|..:.:.:|
Zfish  1365 DIEQYQYLYKAMLSLISTKEN 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 49/252 (19%)
FN3 712..810 CDD:238020 23/121 (19%)
FN3 832..898 CDD:214495 11/69 (16%)
FN3 <867..1269 CDD:442628 90/465 (19%)
fn3 914..998 CDD:394996 22/103 (21%)
R-PTPc-LAR-1 1498..1735 CDD:350401 129/249 (52%)
R-PTP-LAR-2 1784..2021 CDD:350402 78/242 (32%)
ptprgaNP_001316793.1 alpha_CARP_receptor_like 71..319 CDD:239396 64/339 (19%)
FN3 348..426 CDD:214495 20/82 (24%)
R-PTPc-G-1 817..1090 CDD:350505 134/272 (49%)
R-PTP-G-2 1174..1378 CDD:350508 62/208 (30%)
Blue background indicates that the domain is not in the aligned region.

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